HADLEY, WILLIAM M., PHD

EDUCATION
B.S. (Pharmacy) 1967, Purdue University
M.S. (Pharmacology) 1971, Purdue University
Ph.D. (Pharmacology/Toxicology) 1972, Purdue University


EMPLOYMENT

2002 - Present Senior Fellow, Lovelace Respiratory Research Institute, Albuquerque, NM
1996 - 2002 Adjunct Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
5/02 - Present Dean Emeritus, College of Pharmacy, University of New Mexico, Albuquerque, NM
1986 - 5/02 Dean, College of Pharmacy, University of New Mexico, Albuquerque, NM
1985 Acting Dean, College of Pharmacy, University of New Mexico
1984 - 1986 Assistant Dean for Academic Affairs and Graduate Programs, College of Pharmacy, University of New Mexico
1982 - Present Professor of Pharmacy (Pharmacology /Toxicology), tenured, College of Pharmacy, University of New Mexico
1981 Visiting Scientist, Inhalation Toxicology Research Institute, Albuquerque, NM
1976 - 1982 Associate Professor of Pharmacy, (Pharmacology/Toxicology), tenured, College of Pharmacy, University of New Mexico
1972 - 1976 Assistant Professor of Pharmacy, (Pharmacology/Toxicology), College of Pharmacy, University of New Mexico, Albuquerque, NM


PROFESSIONAL AFFILIATIONS
Alpha Zeta Omega (Honorary)
American Association for the Advancement of Science
American Association of Colleges of Pharmacy
Kappa Psi
New Mexico Pharmaceutical Association
New Mexico Hazardous Waste Society
Rocky Mountain Chapter of the Society of Toxicology
Rho Chi
Society of Toxicology
Southwestern Association of Toxicologists
Western Pharmacology Society
Registered Pharmacist (Indiana - active 1967-1976)



 

AREAS OF RESEARCH
The effects of heavy metals on biological systems with specific emphasis on cadmium, the effects of xenobiotics on the immune system with specific emphasis on heavy metals and polycyclic aromatic hydrocarbons, and the nasal biotransformation of xenobiotics with emphasis on the cytochrome P-450 system.



 

REPRESENTATIVE PUBLICATIONS

  1. Hadley, W. M., T. S. Miya and W. F. Bousquet: Cadmium Inhibition of Hepatic Drug Metabolism in the Rat. Toxicol. Appl. Pharmacol. 28(2): 284-291, 1974.

     

  2. Born, J. L. and W. M. Hadley: Inhibition of In Vitro Cytochrome P-450-Catalyzed Reactions by Substituted Pyridines. J. Pharm. Sci. 69(4): 465-466, 1980.

     

  3. Dahl, A. R., W. M. Hadley, F. F. Hahn, J. M. Benson and R. O. McClellan: Cytochrome P-450-Dependent Monooxygenases in Olfactory Epithelium of Dogs: Possible Role in Tumorigenicity. Science 216: 57-59, 1982.

     

  4. Hadley, W. M. and A. R. Dahl: Cytochrome P-450 Dependent Monooxygenase Activity in Rat Nasal Epithelial Membranes. Toxicol. Lett. 10(4): 417-422, 1982.

     

  5. Hadley, W. M., A. R. Dahl, J. M. Benson, F. F. Hahn and R. O. McClellan: Cytochrome P450 Dependent Monooxygenases in Nasal Epithelial Membranes: Effect of Phenobarbital and Benzo(a)Pyrene. Proc. West. Pharmacol. Soc. 25: 197-199, 1982.

     

  6. Dahl, A. R. and W. M. Hadley: Formaldehyde Production Promoted by Rat Nasal Cytochrome P-450-Dependent Monooxygenases with Nasal Decongestants, Essences, Solvents, Air Pollutants, Nicotine and Cocaine as Substrates. Toxicol. Appl. Pharmacol. 67(2): 200-205, 1983.

     

  7. Hadley, W. M. and A. R. Dahl: Cytochrome P-450-Dependent Monooxygenase Activity in Nasal Membranes of Six Species. Drug Metab. Dispos. 11(3): 275-276, 1983.

     

  8. Born, J. L. and W. M. Hadley: Comparative Distribution of Misonidazole and its Amine Metabolite in Female Swiss Webster Mice. Int. J. Radiat. Oncol. Biol. Phys. 11(6): 1157-1161, 1985.

     

  9. Burchiel, S. W., W. M. Hadley, C. L. Cameron, R. H. Fincher, T. W. Lim and C. C. Stewart: Flow Cytometry Coulter Volume Analysis of Lead- and Cadmium-Induced Cellular Alterations in Bone Marrow Obtained from Young Adult and Aged Balb/c Mice. Toxicol. Lett. 34(1): 89-94, 1986.

     

  10. Burchiel, S. W., W. M. Hadley, C. L. Cameron, R. H. Fincher, T. W. Lim, L. Elias and C. C. Stewart: Analysis of Heavy Metal Immunotoxicity by Multiparameter Flow Cytometry: Correlation of Flow Cytometry and Immune Function Data in B6C3F1 Mice. Int. J. Immunopharmacol. 9(5): 597-610, 1987.

     

  11. Born, J. L. and W. M. Hadley: Isotopic Sensitivity in the Microsomal Oxidation of the Dihydropyridine Calcium Entry Blocker Nifedipine. Chem. Res. Toxicol. 2(1): 57-59, 1989.

     

  12. Hadley, W. M., S. W. Burchiel, T. D. McDowell, J. P. Thilsted, C. M. Hibbs, J. A. Whorton, P. W. Day, M. B. Friedman and R. E. Stoll: Five Month Oral (Diet) Toxicity/Infectivity Study of Bacillus thuringiensis Insecticides in Sheep. Fundam. Appl. Toxicol. 8(2): 236-242, 1987.

     

  13. Burchiel, S. W., W. M. Hadley, S. L. Barton, R. H. Fincher, L. D. Lauer and J. H. Dean: Persistent Suppression of Humoral Immunity Produced by 7,12-Dimethylbenz(a)anthracene (DMBA) in B6C3F1 Mice: Correlation with Changes in Spleen Cell Surface Markers Detected by Flow Cytometry. Int. J. Immunopharmacol. 10(4): 369-376, 1988.

     

  14. Dahl, A. R., J. A. Bond, M. L. Crews, W. M. Hadley and P. J. Sabourin: Nasal Tissue Activation and Detoxication of Inhalants. In Nasal Carcinogenesis in Rodents: Relevance for Human Health Risk (V. J. Feron and M. C. Basland, eds.), pp. 125-133, Pudoc Wageningen, Netherlands, 1989.

     

  15. Dahl, A. R. and W. M. Hadley: Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants. Crit. Rev. Toxicol. 21(5): 345-372, 1991.

     

  16. Lead presenter with Lynn Anspaugh, WERC Teleconference Series, Environmental RISK Management Videoconference Series, How Do We Decide What Is Risky? Technical and Social Methods for Identifying Risk. Broadcast March, 10, 1993. Available on videotape.
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