CHEN, WENSHU, PHD

EDUCATION
M.D. (Medicine) 1991, Fujian Medical University, Fuzhou, Fujian, China
M.S. (Pathology) 1999, Fujian Medical University, Fuzhou, Fujian, China
Ph.D. (Pathology) 2004, Tongji Medical College, Huazhong University of Science and Technology,
     Wuhan, Hubei, China 



EMPLOYMENT

1/10 - Present Associate Research Scientist, Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM
10/08 - 1/10 Research Associate, Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA
2/06 - 9/08 Postdoctoral Fellow, Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM
8/05 - 1/06 Postdoctoral Fellow, Department of Pathology, USC Keck School of Medicine, Children’s Hospital Los Angeles, Los Angeles, CA
7/04 - 7/05 Lecturer and Pathology Residence, Department of Pathology, Tongji Medical College and Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
8/99 - 8/01 Junior Lecturer, Department of Pathology, Fujian Medical University, Fuzhou, Fujian, China
8/91 - 8/96 Residence in Internal Medicine, Jinshan Town Public Health Center, Nanjing County, Fujian, China

 

AREAS OF RESEARCH
TNF family and NF-kB signaling in lung carcinogenesis and treatment. 

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
 

REPRESENTATIVE PUBLICATIONS

  1. Chen, W., D. Yang, P. Zhang and H. Gong: Expression of b-Catenin in Colorectal Adenocarcinomas and Its Significance. Journal of Fujian Medical University 33: 383-386, 1999.

     

  2. Chen, W., D. Yang, P. Zhang and S. Chen: Role of E-Cadherin and a-Catenin in Lymph Node Metastasis of Colorectal Carcinoma. Journal of Fujian Medical University 34: 243-244, 2000.

     

  3. Chen, W., D. Yang, P. Zhang and S. Chen: Immunohistochemical Expression of a-Catenin in Colorectal Cancer and Its Relations with Biological Behavior of the Tumor. Cancer Research on Prevention and Treatment 28: 23-24, 2001.

     

  4. Chen, W., D. Yang, P. Zhang and S. Chen: E-Cadherin and a, b-Catenin Expression and Their Relationships with Proliferation of Colorectal Adenocarcinoma Cells. Journal of Clinical and Experimental Pathology 17: 406-408, 2001.

     

  5. Chen, W., R. Wu, X. Wang, Y. Li and T. Hao: Effect of Lithium on Cell Cycle Progression of Pig Airway Epithelial Cells. Journal of Huazhong University of Science and Technology Health Sciences 24: 318-321, 2004.

     

  6. Li, Y., R. Wu, X. Wang and W. Chen: Effect of Retinoic Acid on b-Catenin/Tcf Signaling in Pig Airway Epithelial Cells. National Medical Journal of China 84: 1130-1131, 2004.

     

  7. Chen, W., T. Hao, X. Wang, D. Tian and R. L. Wu: Rapid Isolation and Culture of Pig Airway Epithelial Cells. Chinese Journal of Pathology 34: 685-687, 2005.

     

  8. Chen, W., R. L. Wu, D. Tian and X. Wang: Role of Glycogen Synthase Kinase 3 in Squamous Differentiation of Pig Airway Epithelial Cells: A Primary Study. Acta Physiologica Sinica 57: 467-472, 2005.

     

  9. Tian, D., X. Wang, W. Chen and R. Wu: Expression of Glycogen Synthase Kinase 3 in Human, Rat, Mouse, Pig Lung and Cultured Pig Tracheobronchial Epithelial Cells. Chinese Journal of Histochemistry and Cytochemistry 14: 598-602, 2005.

     

  10. Tian, D., M. Zhu, W. Chen, J. Li, R. Wu and X. Wang: Role of Glycogen Synthase Kinase 3 in Squamous Differentiation Induced by Cigarette Smoke in Porcine Tracheobronchial Epithelial Cells. Food Chem. Toxicol. 44(9): 1590-1596, 2006.

     

  11. Chen, W., X. Wang, J. Zhuang, L. Zhang and Y. Lin: Induction of Death Receptor 5 and Suppression of Survivin Contribute to Sensitization of TRAIL-Induced Cytotoxicity by Quercetin in Non-small Cell Lung Cancer Cells.Carcinogenesis 28(10): 2114-2121, 2007.

     

  12. Ju, W., X. Wang, W. Chen, H. Shi, S. A. Belinsky and Y. Lin: A Critical Role of Luteolin-Induced Reactive Oxygen Species in Blockage of Tumor Necrosis Factor-Activated Nuclear Factor-kB Pathway and Sensitization of Apoptosis in Lung Cancer Cells. Mol. Pharmacol. 71(5): 1381-1388, 2007.

     

  13. Wang, X., W. Chen and Y. Lin: Sensitization of TNF-Induced Cytotoxicity in Lung Cancer Cells by Concurrent Suppression of the NF-kB and Akt Pathways. Biochem. Biophys. Res. Commun. 355(3): 807-812, 2007.

     

  14. Chen, W., X. Wang, L. Bai, X. Liang, J. Zhuang and Y. Lin: Blockage of NF-kB by IKKb- or RelA-siRNA Rather than the NF-kB Super-Suppressor IBa Mutant Potentiates Adriamycin-Induced Cytotoxicity in Lung Cancer Cells.J. Cell. Biochem. 105(2): 554-561, 2008.

     

  15. Chen, W., R. Wu and X. Wang: b-Catenin/Tcf Signaling in Squamous Differentiation of Pig Airway Epithelial Cells. Journal of Huazhong University of Science and Technology Health Sciences 28(2): 121-124, 2008.

     

  16. Wang, X., W. Chen, W. Zeng, L. Bai, Y. Tesfaigzi, S. A. Belinsky and Y. Lin: Akt-Mediated Eminent Expression of c-FLIP and Mcl-1 Confers Acquired Resistance to TRAIL-Induced Cytotoxicity to Lung Cancer Cells. Mol. Cancer Ther. 7(5): 1156-1163, 2008.

     

  17. Bai, L., W. Chen, W. Chen, X. Wang, H. Tang and Y. Lin: IKKb-Mediated Nuclear Factor-kB Activation Attenuates Smac Mimetic-Induced Apoptosis in Cancer Cells. Mol. Cancer Ther. 8(6): 1636-1645, 2009.
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