BELINSKY, STEVEN A., PHD

EDUCATION
B.S. (Zoology) 1978, The University of North Carolina
Ph.D. (Toxicology) 1984, The University of North Carolina


 

EMPLOYMENT


2007 - Present Associate Director, Johns Hopkins Lung SPORE
2002 - Present Co-Director, Cancer Epidemiology and Control Program, University of New Mexico Cancer Center, Albuquerque, NM
2001 - 2007 Deputy Director, New Mexico National Institute Environmental Health Sciences (NIEHS) Center, Albuquerque, NM
2001 - Present Clinical Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1997 - Present Director, Lung Cancer Program; Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
1997 - Present Adjunct Associate Professor, Department of Biochemistry and Molecular Genetics, University of New Mexico, Albuquerque, NM
1992 - Present Adjunct Associate Professor, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN
1991 - 2000 Clinical Associate Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1991 - Present Associate Scientist, University of New Mexico Cancer Center, Albuquerque, NM
1990 - 1998 Scientist, Lovelace Respiratory Research Institute (formerly Inhalation Toxicology Research Institute), Albuquerque, NM
1986 - 1990 Senior Staff Fellow, NIEHS, Research Triangle Park, NC
1984 - 1986 Postdoctoral Fellow, NIEHS, Research Triangle Park, NC
1980 - 1984 Graduate Student, Curriculum in Toxicology, The University of North Carolina, Chapel Hill, NC
1978 - 1979 Research Technician, Department of Pharmacology, The University of North Carolina, Chapel Hill, NC


PROFESSIONAL AFFILIATIONS
American Association for Cancer Research
International Association for the Study of Lung Cancer
East Coast Oncology Group
Environmental Mutagen Society
American Society for Clinical Oncologists

AREAS OF RESEARCH
The general approach of Dr. Belinsky's research is to use in vivo and in vitro animal and human models to identify and define mechanistically genetic and epigenetic changes involved in cancer development and progression. Emphasis is on conducting translational research that can ultimately lead to novel approaches for chemoprevention and intervention. Current areas of research include: 1) using a rodent model to define mechanisms which underlie aberrant CpG island methylation of tumor suppressor genes, 2) modulating cytosine DNA methyltransferase activity and cancer development, 3) transcriptional regulation of the K-ras and p16 genes, 4) identifying chromosome abnormalities in non- or premalignant bronchial epithelial cells from patients at risk for lung cancer that best predict malignancy, 5) defining the role of CpG island methylation of tumor suppressor genes in the development of human adenocarcinoma of the lung and the influence of environmental exposures on which genes are targeted, 6) developing methylation biomarkers that predict lung cancer, and 7) determining interindividual variation in DNA-repair genes and how this relates to lung cancer susceptibility.



ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
 

REPRESENTATIVE PUBLICATIONS

  1. Liu, H., Y. Zhou, S. E. Boggs, S. A. Belinsky and J. Liu: Cigarette Smoke Induces Demethylation of Prometastatic Oncogene Synuclein-g in Lung Cancer Cells by Downregulation of DNMT3B. Oncogene 26(40): 4900-5910, 2007.
  2. Lyon, C. M., D. M. Klinge, K. C. Liechty, F. D. Gentry, T. H. March, T. Kang, F. D. Gilliland, G. Adamova, G. Rusinova, V. Telnov and S. A. Belinsky: Radiation-Induced Lung Adenocarcinoma is Associated with Increased Frequency of Genes Inactivated by Promoter Hypermethylation. Radiat. Res. 168(4): 409-414, 2007.
  3. Brock, M. V., C. M. Hooker, E. Ota-Machida, Y. Han, M. Guo, S. Ames, S. Glöckner, S. Piantadosi, E. Gabrielson, G. Pridham, K. Pelosky, S. A. Belinsky, S. C. Yang, S. B. Baylin and J. G. Herman: DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer. N. Engl. J. Med. 358(11): 1118-1128, 2008.
  4. Chin, L. J., E. Ratner, S. Leng, R. Zhai, S. Nallur, I. Babar, R.-U. Muller, E. Straka, L. Su, E. A. Burki, R. E. Crowell, R. Patel, T. Kulkarni, R. Homer, D. Zelterman, K. K. Kidd, Y. Zhu, D. C. Christiani, S. A. Belinsky, F. J. Slack and J. B. Weidhaas: A SNP in a let-7 microRNA Complementary Site in the KRAS 3´ Untranslated Region Increases Non-Small Cell Lung Cancer Risk. Cancer Res. 68(20): 8535-8540, 2008.
  5. Damiani, L. A., C. M. Yingling, S. Leng, P. E. Romo, J. Nakamura and S. A. Belinsky: Carcinogen-Induced Gene Promoter Hypermethylation is Mediated by DNMT1 and Causal for Transformation of Immortalized Bronchial Epithelial Cells. Cancer Res. 68(21): 9005-9014, 2008.
  6. Leng, S., A. Bernauer, C. A. Stidley, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, R. E. Crowell and S. A. Belinsky: Association Between Common Genetic Variation in Cockayne Syndrome A and B Genes and Nucleotide Excision Repair Capacity Among Smokers. Cancer Epidemiol. Biomarkers Prev. 17(8): 2062-2069, 2008.
  7. Leng, S., C. A. Stidley, A. Bernauer, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, R. E. Crowell and S. A. Belinsky: Haplotypes of DNMT1 and DNMT3B are Associated with Mutagen Sensitivity Induced by Benzo[a]pyrene Diol Epoxide Among Smokers. Carcinogenesis 29(7): 1380-1385, 2008.
  8. Leng, S., C. A. Stidley, R. Willink, A. Bernauer, K. Do, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, C. Zima, R. E. Crowell and S. A. Belinsky: Double-Strand Break Damage and Associated DNA Repair Genes Predispose Smokers to Gene Methylation. Cancer Res. 68(8): 3049-3056, 2008.
  9. Luxen, S., S. A. Belinsky and U. G. Knaus: Silencing of DUOX NADPH Oxidases by Promoter Hypermethylation in Lung Cancer. Cancer Res. 68(4): 1037-1045, 2008.
  10. Sood, A., C. A. Stidley, M. A. Picchi, J. C. Celedon, F. Gilliland, R. E. Crowell, S. A. Belinsky and Y. Tesfaigzi: Difference in Airflow Obstruction Between Hispanic and Non-Hispanic White Female Smokers. COPD: Jnl. Chron. Obstruct. Pulmon. Dis. 5: 274-281, 2008.
  11. Tessema, M. and S. A. Belinsky: Mining the Epigenome for Methylated Genes in Lung Cancer. Proc. Am. Thorac. Soc. 5(8): 806-810, 2008.
  12. Tessema, M., R. Willink, K. Do, Y. Y. Yu, W. Yu, E. O. Machida, M. Brock, L. Van Neste, C. A. Stidley, S. B. Baylin and S. A. Belinsky: Promoter Methylation of Genes in and Around the Candidate Lung Cancer Susceptibility Locus 6q23-25. Cancer Res. 68(6): 1707-1714, 2008.
  13. Wakamatsu, N., J. B. Collins, J. S. Parker, M. Tessema, N. P. Clayton, T. V. Ton, H. H. Hong, S. A. Belinsky, T. R. Devereaux, R. C. Sills and S. A. Lahousse: Gene Expression Studies Demonstrate that the K-ras/Erk MAP Kinase Signal Transduction Pathway and Other Novel Pathways Contribute to the Pathogenesis of Cumen-Induced Lung Tumors. Toxicol. Pathol. 36(5): 743-752, 2008.
  14. Wang, X., W. Chen, W. Zeng, L. Bai, Y. Tesfaigzi, S. A. Belinsky and Y. Lin: Akt-Mediated Eminent Expression of c-FLIP and Mcl-1 Confers Acquired Resistance to TRAIL-Induced Cytotoxicity to Lung Cancer Cells. Mol. Cancer Ther. 7(5): 1156-1163, 2008.
  15. Bailey, V. J., H. Easwaran, Y. Zhang, E. Griffiths, S. A. Belinsky, J. G. Herman, S. Baylin H. Carraway and J. Wang: MS-qFRET: A Quantum Dot-Based Method for Analysis of DNA Methylation. Genome Res. May 14 [Epub ahead of print], 2009.