Lewis, Stephen J., PhD

EDUCATION
B.S. (Pharmacology) 1978, University of Melbourne
B.S. with Honors (Pharmacology) 1979, University of Melbourne
Ph.D. (Pharmacology) 1982, University of Melbourne 

 

EMPLOYMENT

2007 - Present Adjunct Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2007 - Present Principal Scientist, Galleon Pharmaceuticals, Inc., Philadelphia, PA
2007 - Present Associate Professor, Pediatrics, University of Virginia School of Medicine, Charlottesville, PA
2001 - 2006 Assistant Professor, Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA
1992 - 1999 Assistant Professor, Pharmacology, University of Iowa College of Medicine, Iowa City, IA
1991 - 1992 Senior Scientist, Cardiovascular Center, University of Iowa, Iowa City, IA
1987 - 1991 Scientist, Pharmacology, University of Iowa, Iowa City, IA
1984 - 1987 Research Fellow, Pharmacology, University of Melbourne
1982 - 1984 Postdoctoral Fellow, Pharmacology, University of Melbourne


PROFESSIONAL AFFILIATIONS
Fellow of the High Blood Pressure Council, American Heart Association
Fellow of the International Society of Hypertension


 

REPRESENTATIVE PUBLICATIONS

  1. Lewis, S. J., A. Hoque, T. M. Walton and N. W. Kooy: Potential Role of Nitration and Oxidation Reactions in the Effects of Peroxynitrite on the Function ofb-Adrenoceptor Sub-types in the Rat. Eur. J. Pharmacol. 518: 187-194, 2005.

     

  2. Lewis, S. J., J. E. Graves, J. N. Bates and N. W. Kooy: Peroxynitrite Elicits Dysfunction of Stereoselective S-Nitrosocysteine Recognition Sites. J. Cardiovasc. Pharmacol. 46: 637-645, 2005.

     

  3. Owen, J. R., J. N. Bates and S. J. Lewis: Endogenous Nitrosyl Factors May Inhibit Desensitization of 5-HT3 Receptors on Vagal Cardiopulmonary Afferents.Brain Res. 1059: 167-172, 2005.

     

  4. Peroni, J. F., W. E. Harrison, J. N. Moore, J. E. Graves, S. J. Lewis, T. M. Krunkosky and T. P. Robertson: Black Walnut Extract-Induced Laminitis in Horses is Associated with Heterogeneous Dysfunction of the Laminar Microvasculature. Equine Vet. J. 37: 546-551, 2005.

     

  5. Robertson, T. P., J. P. Peroni, S. J. Lewis and J. N. Moore: Effects of Induction of Capacitative Calcium Entry on Equine Laminar Microvessels. Am. J. Vet. Res. 66: 1877-1880, 2005.

     

  6. Graves, J. E., N. W. Kooy and S. J. Lewis: L-b,b-Dimethylcysteine Attenuates the Hemodynamic Responses Elicited by Systemic Injections of Peroxynitrite in Anesthetized Rats. Br. J. Pharmacol. 148: 7-15, 2006.

     

  7. Lacolley, P., J. R. Owen, J. N. Bates, A. K. Johnson and S. J. Lewis: Tachyphylaxis to 5-HT3 Receptor-Mediated Activation of Vagal Afferents is Prevented by Co-activation of 5-HT2 Receptors. Brain Res. 1093: 105-115, 2006.

     

  8. Lacolley, P., J. R. Owen, K. Sandock, T. H. Lewis, J. N. Bates, T. P. Robertson and S. J. Lewis: 5-HT Activates Vagal Afferent Cell Bodies In Vivo: Role of 5-HT2 and 5-HT3 Receptors. Neuroscience 143: 273-287, 2006.

     

  9. Lacolley, P., J. R. Owen, K. Sandock, T. H. Lewis, J. N. Bates, T. P. Robertson and S. J. Lewis: Occipital Artery Injections of 5-HT May Directly Activate the Cell Bodies of Vagal and Glossopharyngeal Afferent Cell Bodies in the Rat. Neuroscience 143: 289-308, 2006.

     

  10. Lewis, S. J., M. P. Hashmi-Hill, J. R. Owen, K. Sandock, T. P. Robertson and J. N. Bates: The Vasodilator Potency of the Endothelium-Derived Relaxing Factor, L-S-Nitrosocysteine, is Impaired in Spontaneously Hypertensive Rats. Vasc. Pharmacol. 44: 476-490, 2006.

     

  11. Lewis, S. J., M. P. Hashmi-Hill, J. R. Owen, K. Sandock, T. P. Robertson and J. N. Bates: ACE Inhibition Restores the Vasodilator Potency of the Endothelium-Derived Relaxing Factor, L-S-Nitrosocysteine, in Spontaneously Hypertensive Rats. Vasc. Pharmacol. 44: 491-507, 2006.

     

  12. Lewis, S. J., A. Hoque, K. Sandock, T. P. Robertson, J. N. Bates and N. W. Kooy: Differential Effects of Peroxynitrite on the Function of Arginine Basopressin V1a Receptors and Alpha1-Adrenoceptors In Vivo. Vasc. Pharmacol. 46: 24-34, 2006.

     

  13. Lewis, S. J., J. R. Owen and J. N. Bates: S-Nitrosocysteine Elicits Hemodynamic Responses Similar to Those of the Bezold-Jarisch Reflex via Activation of Stereoselective Recognition Sites. Eur. J. Pharmacol. 531: 254-258, 2006.

     

  14. Lewis, S. J., M. D. Travis, M. P. Hashmi-Hill, K. Sandock, T. P. Robertson and J. N. Bates: Differential Effects of Ouabain on the Vasodilator Actions of Nitric Oxide and S-Nitrosothiols In Vivo. Vasc. Pharmacol. 45: 383-394, 2006.

     

  15. Owen, J. R., J. N. Bates and S. J. Lewis: Differential Effects of Nitroblue Tetrazolium on the Hemodynamic Responses Elicited by Activation of a1-Adrenoceptors and 5-HT2 Receptors in Conscious Rats. Eur. J. Pharmacol. 535: 248-252, 2006.

     

  16. Peroni, J. F., J. N. Moore, E. Noschka, M. E. Grafton, M. Aceves-Avila, S. J. Lewis and T. P. Robertson: Predisposition for Venoconstriction in the Equine Laminar Dermis: Implications in Equine Laminitis. J. Appl. Physiol. 100: 756-763, 2006.

     

  17. Possas, O., A. K. Johnson and S. J. Lewis: Role of Nitrosyl Factors in the Hindlimb Vasodilation Produced by Baroreceptor Afferent Nerve Stimulation. Am. J. Physiol. 290: R741-R748, 2006.

     

  18. Whalen, E. J., J. N. Bates, A. K. Johnson and S. J. Lewis: Down-Regulation of Propranolol-Sensitive b-Adrenoceptor Signaling After Inhibition of Nitric Oxide Synthesis. Br. J. Pharmacol. 147: 755-764, 2006.

     

  19. Whalen, E. J., T. B. Saurer, A. K. Johnson and S. J. Lewis: Intracellular cGMP May Promote Ca2+-Dependent and Ca2+-Independent Release of Catecholamines from Sympathetic Nerve Terminals. Vasc. Pharmacol. 45: 102-111, 2006.

     

  20. Hashmi-Hill, M. P., J. E. Graves, K. Sandock, J. N. Bates, T. P. Robertson and S. J. Lewis: Hemodynamic Responses Elicited by Systemic Injections of Flavin Adenine Dinucleotide in Anesthetized Rats. J. Cardiovasc. Pharmacol. 50: 94-102, 2007.

     

  21. Hashmi-Hill, M. P., K. Sandock, J. N. Bates, T. P. Robertson and S. J. Lewis: Flavin Adenine Dinucleotide May Release Preformed Stores of Nitrosyl Factors from the Vascular Endothelium of Conscious Rats. J. Cardiovasc. Pharmacol. 50: 142-154, 2007.

     

  22. Kim, B. H., K. D. Sandock, T. P. Robertson, S. J. Lewis and C. C. Akoh: Dietary Effects of Structured Lipids and Phytosteryl Esters on Cardiovascular Function in Spontaneously Hypertensive Rats. J. Cardiovasc. Pharmacol. 50: 178-186, 2007.

     

  23. Peroni, J. F., J. N. Moore, E. Noschka, T. H. Lewis, S. J. Lewis and T. P. Robertson: Effect of Voltage-Gated and Capacitative Calcium Entry Blockade on Agonist-Induced Constriction of Equine Laminar Blood Vessels. Am. J. Vet. Res. 68: 722-729, 2007.

     

  24. Robertson, T. P., J. N. Moore, E. Noschka, T. H. Lewis, S. J. Lewis and J. F. Peroni: Evaluation of Activation of Protein Kinase C During Agonist-Induced Constriction of Veins Isolated from the Laminar Dermis of Horses. Am. J. Vet. Res. 68: 664-669, 2007.

     

  25. Robertson, T. P., J. F. Peroni, E. Noschka, T. H. Lewis, M. E. Grafton, S. J. Lewis and J. N. Moore: Effects of Rho-Kinase or Src Protein Tyrosine Kinase Inhibition on Agonist-Induced Constriction of Arteries and Veins of the Equine Laminar Dermis. Am. J. Vet. Res. 68: 886-894, 2007.

     

  26. Whalen, E. J., S. J. Lewis and A. K. Johnson: Hemodynamic Responses Elicited by g2-MSH or Blood Replacement in Hemorrhaged Rats. J. Surg. Res. 139: 121-127, 2007.

     

  27. Kim, B. H., K. D. Sandock, T. P. Robertson, S. J. Lewis and C. C. Akoh: Dietary Structured Lipids and Phytosteryl Esters: Blood Lipid and Cardiovascular Status in Spontaneously Hypertensive Rats. Lipids (in press).
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