RENNARD, STEPHEN I., MD

EDUCATION
A.B. (Folklore & Mythology) 1971, Harvard College
G.S.A.S. (Biochemistry & Genetics) 1972, Harvard University
M.D. (Medicine) 1975, Baylor College of Medicine

EMPLOYMENT

2002 - Present Senior Fellow, Lovelace Respiratory Research Institute, Albuquerque, NM
1990 - Present Larson Professor of Medicine, Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE
1984 - 1997 Chief, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center
1984 - 1990 Stokes Shackleford Associate Professor, Department of Internal Medicine
1979 - 1984 Staff Fellow, NHLBI, NIH, Bethesda, MD
1977 - 1979 Research Associate, NIDR, NIH, Bethesda, MD
1975 - 1977 Resident, Internal Medicine, Barnes Hospital, Washington University, St. Louis, MO
1975 - 1976 Intern, Internal Medicine, Barnes Hospital, Washington University, St. Louis, MO




AREAS OF RESEARCH
Professor Rennard maintains an active program of clinical investigation in COPD and smoking cessation and a program of basic research in the mechanism of lung tissue repair and remodeling.

 

REPRESENTATIVE PUBLICATIONS

  1. Fang, Q., X. Liu, M. Al-Mugotir, T. Kobayashi, S. Abe, T. Kohyama and S. I. Rennard: Thrombin and TNF-alpha/IL-1beta Synergistically Induce Fibroblast-Mediated Collagen Gel Degradation. Am. J. Respir. Cell Mol. Biol. 35(6): 714-721, 2006.

     

  2. Mikuls, T. R., J. R. O’Dell, R. Ertl, D. A. Bergman and S. I. Rennard: Examining the Exhaled Levels of Hydrogen Peroxide in Rheumatoid Arthritis: A Pilot Study. Ann. Rheum. Dis. 65(9): 1252-1253, 2006.

     

  3. Rennard, S. I., E. D. Glover, S. Leischow, D. M. Daughton, P. N. Glover, M. Muramoto, M. Franzon, T. Danielsson, B. Landfeldt and A. Westin: Efficacy of the Nicotine Inhaler in Smoking Reduction: A Double-Blind, Randomized Trial. Nicotine Tob. Res. 8(4): 555-564, 2006.

     

  4. Rennard, S. I., S. Togo and O. Holz: Cigarette Smoke Inhibits Alveolar Repair: A Mechanism for the Development of Emphysema. Proc. Am. Thorac. Soc. 3(8): 703-708, 2006.

     

  5. Calverley, P. M. and S. I. Rennard: What have we Learned from Large Drug Treatment Trials in COPD? Lancet 370(9589): 774-785, 2007.

     

  6. Foster, J. A., B. P. Yawn, A. Maziar, T. Jenkins, S. I. Rennard and L. Casebeer: Enhancing COPD Management in Primary Care Settings. MedGenMed. 9(3): 24, 2007.

     

  7. Gonzales, D., S. I. Rennard, D. E. Jorenby and K. R. Reeves: Comment: Oral Varenicline for Smoking Cessation. Ann. Pharmacother. 41(4): 720-721, 2007.

     

  8. Kamio, K., X. Liu, H. Sugiura, S. Togo, T. Kobayashi, S. Kawasaki, X. Wang, L. Mao, Y. Ahn, C. Hogaboam, M. L. Toews and S. I. Rennard: Prostacyclin Analogs Inhibit Fibroblast Contraction of Collagen Gels Through the cAMP-PKA Pathway. Am. J. Respir. Cell Mol. Biol. 37(1): 113-120, 2007.

     

  9. Liu, X., A. M. Das, J. Seideman, D. Griswold, C. N. Afuh, T. Kobayashi, S. Abe, Q. Fang, M. Hashimoto, H. Kim, X. Wang, L. Shen, S. Kawasaki and S. I. Rennard: The CC Chemokine Ligand 2 (CCL2) Mediates Fibroblast Survival Through IL-6. Am. J. Respir. Cell Mol. Biol. 37(1): 121-128, 2007.

     

  10. Ohnishi, T., L. L. Arnold, J. He, N. M. Clark, S. Kawasaki, S. I. Rennard, C. W. Boyer and S. M. Cohen: Inhalation of Tobacco Smoke Induces Increased Proliferation of Urinary Bladder Epithelium and Endothelium in Female C57BL/6 Mice. Toxicology 241(1-2): 58-65, 2007.

     

  11. Rennard, S. I., C. Fogarty, S. Kelsen, W. Long, J. Ramsdell, J. Allison, D. Mahler, C. Saadeh, T. Siler, P. Snell, P. Korenblat, W. Smith, M. Kaye, M. Mandel, C. Andrews, R. Prabhu, J. F. Donohue, R. Watt, K. H. Lo, R. Schlenker-Herceg, E. S. Barnathan, J. Murray and COPD Investigators: The Safety and Efficacy of Infliximab in Moderate to Severe Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 175(9): 926-934, 2007.

     

  12. Rennard, S. I. and T. Higenbottam: Exacerbation-Free COPD: A Goal Too Far? Proc. Am. Thorac. Soc. 4(8): 583-585, 2007.

     

  13. Sugiura, H., X. Liu, F. Duan, S. Kawasaki, S. Togo, K. Kamio, X. Q. Wang, L. Mao, Y. Ahn, R. F. Ertl, T. W. Bargar, A. Berro, T. B. Casale and S. I. Rennard: Cultured Lung Fibroblasts from Ovalbumin-Challenged “Asthmatic” Mice Differ Functionally from Normal. Am. J. Respir. Cell Mol. Biol. 37(4): 424-430, 2007.

     

  14. Sugiura, H., X. Liu, S. Togo, T. Kobayashi, L. Shen, S. Kawasaki, K. Kamio, X. Q. Wang, L. J. Mao and S. I. Rennard: Prostaglandin E(2) Protects Human Lung Fibroblasts from Cigarette Smoke Extract-Induced Apoptosis via EP(2) Receptor Activation. J. Cell. Physiol. 210(1): 99-110, 2007.

     

  15. Cazzola, M., W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, Burge, P. S., P. M. Calverley, B. R. Celli, P. W. Jones, D. A. Mahler, B. Make, M. Miravitlles, C. P. Page, P. Palange, D. Parr, M. Pistolesi, S. I. Rennard, M. P. Rutten-van Mölken, R. Stockley, S. D. Sullivan, J. A. Wedzicha, E. F. Wouters and American Thoracic Society; European Respiratory Society Task Force on Outcomes of COPD: Outcomes for COPD Pharmacological Trials: From Lung Function to Biomarkers. Eur. Respir. J. 31(2): 416-469, 2008.

     

  16. Demeo, D. L., E. J. Campbell, A. F. Barker, M. L. Brantly, E. Eden, N. G. McElvaney, S. I. Rennard, R. A. Sandhaus, J. M. Stocks, J. K. Stoller, C. Strange, G. Turino and E. K. Silverman: IL10 Polymorphisms are Associated with Airflow Obstruction in Severe alpha1-Antitrypsin Deficiency. Am. J. Respir. Cell Mol. Biol. 38(1): 114-120, 2008.

     

  17. Fang, Q., L. Mao, T. Kobayashi, X. Wang, T. A. Wyatt, H. Kim, X. Liu and S. I. Rennard: PKCdelta Mediates Thrombin-Augmented Fibroblast-Mediated Collagen Gel Contraction. Biochem. Biophys. Res. Commun. 369(4): 1199-1203, 2008.

     

  18. Hashimoto, M., X. Wang, L. Mao, T. Kobayashi, S. Kawasaki, N. Mori, M. L. Toews, H. J. Kim, R. Cerutis, X. Liu and S. I. Rennard: Sphingosine 1-Phosphate Potentiates Human Lung Fibroblast Chemotaxis Through the S1P2 Receptor. Am. J. Respir. Cell Mol. Biol. Mar 26 [Epub ahead of print], 2008.

     

  19. Houfek, J. F., J. R. Atwood, R. M. Wolfe, S. Agrawal, G. M. Reiser, G. B. Schaefer and S. I. Rennard: Knowledge and Beliefs About Genetics and Smoking Among Visitors and Staff at a Health Care Facility. Public Health Nurs. 25(1): 77-87, 2008.

     

  20. Kamio, K, T. Sato, X. Liu, H. Sugiura, S. Togo, T. Kobayashi, S. Kawasaki, X. Wang, L. Mao, Y. Ahn, O. Holz, H. Magnussen and S. I. Rennard: Prostacyclin Analogs Stimulate VEGF Production from Human Lung Fibroblasts in Culture. Am. J. Physiol. Lung Cell. Mol. Physiol. 294(6): L1226-L1232, 2008.

     

  21. Merchant, D., R. L. Ertl, S. I. Rennard, D. W. Stanley and J. S. Miller: Eicosanoids Mediate Insect Hemocyte Migration. J. Insect. Physiol. 54(1): 215-221, 2008.

     

  22. Rennard, S. I.: Update on Smoking Cessation Interventions for the Primary Care Physician. Introduction. Am. J. Med. 121(4 Suppl. 1): S1-S2, 2008.

     

  23. Togo, S., O. Holz, X. Liu, H. Sugiura, K. Kamio, X. Wang, S. Kawasaki, Y. Ahn, K. Fredriksson, C. M. Skold, K. C. Mueller, D. Branscheid, L. Welker, H. Watz, H. Magnussen and S. I. Rennard: Lung Fibroblast Repair Functions in COPD Patients are Altered by Multiple Mechanisms. Am. J. Respir. Crit. Care Med. May 8 [Epub ahead of print], 2008.

     

  24. Wardyn, G. G., S. I. Rennard, S. K. Brusnahan, T. R. McGuire, M. L. Carlson, L. M. Smith, S. McGranaghan and J. G. Sharp: Effects of Exercise on Hematological Parameters, Circulating Side Population Cells, and Cytokines. Exp. Hematol. 36(2): 216-223, 2008.
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