EDUCATION
 M.D. (Medicine) 1999, Department of Public Health, Shandong Medical
      University
 Ph.D. (Toxicology) 2004, National Institute of Occupational Health and Poison
      Control, Chinese Center for Disease Control and Prevention
 
 
 EMPLOYMENT

PROFESSIONAL AFFILIATIONS
 American Association for Cancer Research
 Molecular Epidemiology Group of the American Association for Cancer Research
 
 AREAS OF RESEARCH
 Molecular epidemiological approach is employed to study the biomarkers in smokers with high risk for lung cancer in general population and in workers occupationally exposed to chemicals that include coke-oven emission, formaldehyde, and trichloroethylene. Three classes of biomarkers are studied which include biomarker of exposure, biomarker of effect, and biomarker of susceptibility. This approach allows us to understand the mechanism of action in in vivo human model and the biomarkers discovered and validated in these studies will lead to novel approach for chemoprevention and intervention. My current studies include: Genetic determinants such as single nucleotide polymorphisms (SNPs) for gene-specific promoter methylation in exfoliated cells from the lung; Association between DNA repair capacity and gene-specific promoter methylation in exfoliated cells from the lung; Genetic determinants for DNA repair capacity.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
 
 

REPRESENTATIVE PUBLICATIONS

1. Chen, K., Q. Jiang, X. Ma, K. Yao, S. Leng, W. Yu and H. Zhou: Associations Between Genetic Polymorphisms of Glutathione S-Transferase M1 and T1, Smoking and Susceptibility to Colorectal Cancer: A Case-Control Study. Chinese Journal of Oncology 26: 645-648, 2004.

    

2. Dai, Y., S. Leng, L. Li, Y. Niu, H. Huang, J. Cheng and Y. Zheng: Genetic Polymorphisms of Cytokine Genes and Risk for Trichloroethylene-Induced Severe Generalized Dermatitis: A Case-Control Study. Biomarkers 9: 470-478, 2004.

    

3. Dai, Y., S. Leng, Z. F. Pan, S. M. Rappaport and Y. X. Zheng: Preliminary Study on Naphthalene-Metabolites-Albumin Adduct as an Exposure Biomarker for Coke Oven Workers. Chinese Journal of Preventive Medicine 38: 392-395, 2004.

    

4. Leng, S., J. Cheng, Z. Pan, C. Huang, Y. Niu, Y. Dai, B. Li, F. He and Y. Zheng: Associations Between XRCC1 and ERCC2 Polymorphisms and DNA Damage in Peripheral Blood Lymphocyte Among Coke Oven Workers. Biomarkers 9: 395-406, 2004.

    

5. Leng, S., Y. Dai, Y. Niu, Z. Pan, X. Li, J. Cheng, F. He and Y. Zheng: Effects of Genetic Polymorphisms of Metabolic Enzymes on Cytokinesis-Block Micronucleus in Peripheral Blood Lymphocyte Among Coke Oven Workers. Cancer Epidemiol. Biomarkers Prev. 13: 1631-1639, 2004.

    

6. Leng, S., Y. Zheng, C. Huang, Y. Dai, X. Li, Y. Niu, Z. Pan, T. Li and F. He: Genetic Polymorphism of Microsomal Epoxide Hydrolase Could Influence Urinary 1-Hydroxypyrene Levels in Coke Oven Workers. Chinese Journal of Industrial Hygiene and Occupational Diseases 22: 245-249, 2004.

    

7. Leng, S., Y. Zheng, W. Zhang, Y. Dai, Y. Niu, Y. Wang, Y. Gu, Z. Pan, J. Xiao, Z. Wang, T. Li and F. He: Genetic Damage in Peripheral Blood Lymphocyte Among Coke Oven Workers. Chinese Journal of Industrial Hygiene and Occupational Diseases 22: 29-32, 2004.

    

8. Dai, Y., Y. Niu, J. Cheng and S. Leng: The Immunological Effects in Guinea Pig Sensitized by Trichloroethylene. Journal of Hygiene Research 34: 16-18, 2005.

    

9. Dai, Y., Y. Niu, J. Cheng, S. Leng and Y. Zheng: Immunological Mechanism in Development of Allergic Dermatitis in Guinea Pig Induced by Trichloroethylene In Vitro. Chinese Journal of Industrial Hygiene and Occupational Diseases 23: 129-131, 2005.

    

10. Dai, Y., Y. Niu and S. Leng: The Establishment of Animal Model of Trichloroethylene-Induced Allergy. Chinese Journal of Preventive Medicine 39: 55, 2005.

     

11. Leng, S., J. Cheng, L. Zhang, Y. Niu, Y. Dai, Z. Pan, B. Li, F. He and Y. Zheng: The Association of XRCC1 Haplotypes and Chromosomal Damage Levels in Peripheral Blood Lymphocyte Among Coke-Oven Workers. Cancer Epidemiol. Biomarkers Prev. 14: 1295-1301, 2005.

     

12. Leng, S. and Y. He: A Review for the Biomarkers of Xenobiotic-Induced DNA Damage and Repair in Humans. Chinese Journal of Preventive Medicine 39: 210-212, 2005.

     

13. Zhang, Y., Q. Liu, Q. Liu, H. Duan, J. Cheng, S. Jiang, X. Huang, S. Leng, F. He and Y. Zheng: Association Between Metabolic Gene Polymorphisms and Susceptibility to Peripheral Nerve Damage in Workers Exposed to n-Hexane: A Preliminary Study. Biomarkers 11(1): 61-69, 2006.

     

14. Cheng, J., S. Leng, Y. Dai, C. Huang, Z. Pan, Y. Niu, B. Li and Y. Zheng: Association Between Nucleotide Excision Repair Gene Polymorphisms and Chromosomal Damage in Coke-Oven Workers. Biomarkers 12(1): 76-86, 2007.

     

15. Li, H., Y. Dai, H. Huang, L. Li, S. Leng, J. Cheng, Y. Niu, H. Duan, Q. Liu, X. Zhang, X. Huang, J. Xie, Z. Feng, J. Wang, J. He and Y. Zheng: HLA-B*1301 as a Biomarker for Genetic Susceptibility to Hypersensitivity Dermatitis Induced by Trichloroethylene Among Workers in China. Environ Health Perspect. 115(11): 1553-1556, 2007.

     

16. Qiu, L., S. Leng, Z. Wang, Y. Dai, Y. Zheng and Z. Wang: Path Analysis of Biomarkers of Exposure and Early Biological Effects Among Coke-Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons. Cancer Epidemiol. Biomarkers Prev. 16(6): 1193-1199, 2007.

     

17. Bin, P., S. Leng, J. Cheng, Y. Dai, C. Huang, Z. Pan, Y. Niu, H. Duan, H. Li, Q. Liu, W. Chen and Y. Zheng: Association of Aryl Hydrocarbon Receptor Gene Polymorphisms and Urinary 1-Hydroxypyrene in Polycyclic Aromatic Hydrocarbons Exposed Workers. Cancer Epidemiol. Biomarkers Prev. 17(7): 1702-1708, 2008.

     

18. Chin, L., E. Ratner, S. Leng, R. Zhai, S. Nallur, I. Babar, R.-U. Muller, E. Straka, L. Su, E. A. Burki, R. E. Crowell, R. Patel, T. Kulkarni, R. Homer, D. Zelterman, K. K. Kidd, Y. Zhu, D. C. Christiani, S. A. Belinsky, F. J. Slack and J. B. Weidhaas. A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk. Cancer Res. 68(20): 8535-8540, 2008.

     

19. Damiani, L. A., C. M. Yingling, S. Leng, P. E. Romo, J. Nakamura and S. A. Belinsky: Carcinogen-Induced Gene Promoter Hypermethylation is Mediated by DNMT1 and Causal for Transformation of Immortalized Bronchial Epithelial Cells. Cancer Res. 68(21): 9005-9014, 2008.

     

20. Leng, S., A. Bernauer, C. A. Stidley, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, R. E. Crowell and S. A. Belinsky: Association Between Common Genetic Variation in Cockayne Syndrome A and B Genes and Nucleotide Excision Repair Capacity Among Smokers. Cancer Epidemiol. Biomarkers Prev. 17(8): 2062-2069, 2008.

     

21. Leng, S., C. A. Stidley, A. Bernauer, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, R. E. Crowell and S. A. Belinsky: Haplotypes of DNMT1 and DNMT3B are Associated with Mutagen Sensitivity Induced by Benzo[a]pyrene Diol Epoxide Among Smokers. Carcinogenesis 29(7): 1380-1385, 2008.

     

22. Leng, S., C. A. Stidley, R. Willink, A. Bernauer, K. Do, M. A. Picchi, X. Sheng, M. A. Frasco, D. Van Den Berg, F. D. Gilliland, C. Zima, R. E. Crowell and S. A. Belinsky: Double-Strand Break Damage and Associated DNA Repair Genes Predispose Smokers to Gene Methylation. Cancer Res. 68(8): 3049-3056, 2008.