SINGH, SHASHI P., PHD

EDUCATION
B.S. (Chemistry/Biology) 1968, Bhagalpur University, India
M.S. (Chemistry) 1979, University of Nebraska
Ph.D. (Biochemistry) 1989, Utah State University

EMPLOYMENT


2000 - Present Associate Research Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1997 - 1999 Research Associate, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1993 - 1997 Research Associate, VA Hospital, Department of Hematology, Salt Lake City, UT
1992 - 1993 Postdoctoral Research Fellow, Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah
1989 - 1991 Postdoctoral Research Fellow, Department of Biochemistry/Molecular Biology, University of Texas Medical School, Houston, TX
1983 - 1989 Teaching/Research Assistant, Utah State University, Logan, UT
1979 - 1982 Research Assistant, University of Nebraska Medical School, Omaha, NE
1976 - 1979 Teaching Assistant, University of Nebraska, Lincoln, NE
1972 - 1974 Research Assistant, Department of Biochemistry, Northwestern University Medical School, Chicago, IL


PROFESSIONAL AFFILIATION
American Association for Advancement of Science
Society of Toxicology
American Society of Neuroimmunology
 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED


 

REPRESENTATIVE PUBLICATIONS


 

  1. Wen, Y., K. Anwer, S. P. Singh and B. M. Sanborn: Protein Kinase-A Inhibits Phopholipase-C Activity and Alters Protein Phosphorylation in Rat Myometrial Plasma Membranes. Endocrinology 131: 1377-1382, 1992.

     

  2. Singh, S. P. and D. E. Moody: A Radiometric TLC Assay of Liver Microsomal Dextromethorphan O-Demethylation. J. Pharm. Biomed. Anal. 13: 1027-1032, 1995.

     

  3. Endo, M., P. G. Beatty, T. M. Vreeke, C. T. Wittwer, S. P. Singh and C. J. Parker: Syngeneic Bone Marrow Transplantation without Conditioning in a Patient with Paroxysmal Nocturnal Hemoglobinuria: In Vivo Evidence that the Mutant Stem Cells Have a Survival Advantage. Blood 88: 742-750, 1996.

     

  4. Endo, M., R. E. Ware, T. M. Vreeke, S. P. Singh, T. A. Howard, A. Tomita, M. H. Holguin and C. J. Parker: Molecular Basis of the Heterogeneity of Expression of Glycosyl Phosphatidylinositol Anchored Proteins in Paroxysmal Nocturnal Hemoglobinuria. Blood 87: 2546-2557, 1996.

     

  5. Henderson, R. F., E. B. Barr, M. Sopori, S. Singh, R. Kalra, C. Conn, Y. Tesfaigzi, T. March and D. B. Mash: Effects of Inhalation Exposure to Low Levels of Sarin in Fischer 344 Rats. In Proceedings of the 2000 Medical Defense Bioscience Review, Vol. 2, pp. 495-501, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 2000.

     

  6. Kalra, R., S. P. Singh, S. M. Savage, G. L. Finch and M. L. Sopori: Effects of Cigarette Smoke on Immune Response: Chronic Exposure to Cigarette Smoke Impairs Antigen-Mediated Signaling in T Cells and Depletes IP3-Sensitive Ca2+ Stores. J. Pharmacol. Exp. Ther. 293: 166-171, 2000.

     

  7. Singh, S. P., R. Kalra, P. Puttfarcken, A. Kozak, J. Tesfaigzi and M. L. Sopori: Acute and Chronic Nicotine Exposures Modulate the Immune System Through Different Pathways. Toxicol. Appl. Pharmacol. 164: 65-72, 2000.

     

  8. Henderson, R. F., E. B. Barr, W. B. Blackwell, C. R. Clark, C. A. Conn, R. Kalra, T. H. March, M. L. Sopori, Y. Tesfaigzi, M. G. Ménache, D. C. Mash, K. Dokladny, W. Kozak, A. Kozak, M. Wachulec, K. Rudolph, M. J. Kluger, S. P. Singh, S. Razani-Boroujerdi and R. J. Langley: Response of F344 Rats to Inhalation of Subclinical Levels of Sarin: Exploring Potential Causes of Gulf War Illness. Toxicol. Ind. Health 17: 294-297, 2001.

     

  9. Kalra, R., S. P. Singh, D. Kracko, S. G. Matta, B. M. Sharp and M. L. Sopori: Chronic Self-Administration of Nicotine in Rats Impairs T Cell Responsiveness. J. Pharmacol. Exp. Ther. 302: 935-939, 2002.

     

  10. Kalra, R., S. P. Singh, S. Razani-Boroujerdi, R. J. Langley, W. B. Blackwell, R. F. Henderson and M. L. Sopori: Subclinical Doses of the Nerve Gas Sarin Impair T Cell Responses Through the Autonomic Nervous System. Toxicol. Appl. Pharmacol. 184(2): 82-87, 2002.

     

  11. Tesfaigzi, Y., S. P. Singh, J. E. Foster, J. Kubatko, E. B. Barr, P. M. Fine, J. D. McDonald, F. F. Hahn and J. L. Mauderly: Health Effects of Subchronic Exposure to Low Levels of Wood Smoke in Rats. Toxicol. Sci. 65: 115-125, 2002.

     

  12. Singh, S. P., E. G. Barrett, R. Kalra, S. Razani-Boroujerdi, R. J. Langley, V. Kurup, Y. Tesfaigzi and M. L. Sopori: Prenatal Cigarette Smoke Decreases Lung cAMP and Increases Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med. 168(3): 342-347, 2003.

     

  13. Kalra, R., S. P. Singh, J. C. Pena-Philippides, R. J. Langley, S. Razani-Boroujerdi and M. L. Sopori: Immunosuppressive and Anti-inflammatory Effects of Nicotine Administered by Patch in an Animal Model. Clin. Diagn. Lab. Immunol. 11(3): 563-568, 2004.

     

  14. Langley, R. J., R. Kalra, N. C. Mishra, F. F. Hahn, S. Razani-Boroujerdi, S. P. Singh, J. M. Benson, J. C. Pena-Philippides, E. B. Barr and M. L. Sopori: A Biphasic Response to Silica. I. Immunostimulation is Restricted to the Early Stage of Silicosis in Lewis Rats. Am. J. Respir. Cell Mol. Biol. 30(6): 823-829, 2004.

     

  15. Razani-Boroujerdi, S., S. P. Singh, C. Knall, F. F. Hahn, J. C. Pena-Philippides, R. Kalra, R. J. Langley and M. L. Sopori: Chronic Nicotine Inhibits Inflammation and Promotes Influenza Infection. Cell. Immunol. 230(1): 1-9, 2004.

     

  16. Sopori, M. L., S. Razani-Boroujerdi and S. P. Singh: Chapter 8, Immunomodulatory Effects of Cigarette Smoke/Nicotine. In Infectious Diseases and Substance Abuse (H. Friedman, T. W. Klein and M. Bendinelli, eds.), Kluwer Academic/Plenum Publishers, New York, 2005.

     

  17. Tesfaigzi, Y., J. D. McDonald, M. D. Reed, S. P. Singh, G. DeSanctis, P. R. Eynott, F. F. Hahn, M. J. Campen and J. L. Mauderly: Low-Level Subchronic Exposure to Wood Smoke Exacerbates Inflammatory Responses in Allergic Rats. Toxicol. Sci. 88(2): 505-513, 2005.

     

  18. Singh, S. P., S. Razani-Boroujerdi, J. C. Pena-Philippides, R. J. Langley, N. C. Mishra and M. L. Sopori: Early Postnatal Exposure to Cigarette Smoke Impairs the Antigen-Specific T-Cell Responses in the Spleen. Toxicol. Lett. 167(3): 231-237, 2006.

     

  19. Pena-Philippides, J. C., S. Razani-Boroujerdi, S. P. Singh, R. J. Langley, N. C. Mishra, R. F. Henderson and M. L. Sopori: Long- and Short-Term Changes in the Neuroimmune-Endocrine Parameters Following Inhalation Exposures of F344 Rats to Low-Dose Sarin. Toxicol. Sci. 97(1): 181-188, 2007.

     

  20. Razani-Boroujerdi, S., R. T. Boyd, M. I. Davila-Garcia, J. S. Nandi, N. C. Mishra, S. P. Singh, J. C. Philippides, R. Langley and M. L. Sopori: T Cells Express a7-Nicotinic Acetylcholine Receptor Subunits that Require a Functional TCR and Leukocyte-Specific Tyrosine Kinase for Nicotine-Induced Ca2+ Response. J. Immunol. 179(5): 2889-2898, 2007.

     

  21. Mishra, N. C., J. Rir-Sima-ah, R. J. Langley, S. P. Singh, J. C. Peña-Philippides, T. Koga, S. Razani-Boroujerdi, J. Hutt, M. Campen, K. C. Kim, Y. Tesfaigzi and M. L. Sopori: Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens. J. Immunol. 180(11): 7655-7663, 2008.

     

  22. Singh, S. P., N. C. Mishra, J. Rir-sima-ah, M. Campen, V. Kurup, S. Razani-Boroujerdi and M. L. Sopori: Maternal Exposure to Secondhand Cigarette Smoke Primes the Lung for Induction of Phosphodiesterase4D5 Isozyme and Exacerbated Th2 Responses; Rolipram Attenuates the Airway Hyperreactivity and Muscarinic Receptor Expression but not Lung Inflammation and Atopy. J. Immunol. 183(3): 2115-2121, 2009.
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