LECLAIRE, ROSS D., DVM, PHD, MSS, DABT, FELLOW ATS

EDUCATION
 B.S. (Veterinary Science) 1980, University of Minnesota
 D.V.M. with Honors (Veterinary Medicine) 1982, University of Minnesota
 Ph.D. (Toxicology) 1991, University of Kansas Medical Center
 M.S.S. (Masters of Strategic Studies) 2001, U.S. Army War College
 

PROFESSIONAL CERTIFICATION
 Veterinary Medicine and USDA Accreditation – New Mexico, Minnesota, Wisconsin, and California
 Diplomate, American Board of Toxicology, 1995
 Certified Acquisition Professional, Systems Planning, Research, Development, and Engineering
      (SPRDE, Level III) and Acquisition Program Management (Level II)
 Fellow, Academy of Toxicological Sciences


 
 EMPLOYMENT

7/09 - Present President, Lovelace Biomedical and Environmental Research Institute (subsidiary of LRRI); Director of Federal Programs and Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
6/07 - 7/09 Director of Defense Studies and Senior Scientist, Lovelace Respiratory Research Institute; Vice President, Lovelace Biomedical and Environmental Research Institute (subsidiary of LRRI), Albuquerque, NM
2007 - Present Graduate Faculty, Department of Pharmacy, University of New Mexico, Albuquerque, NM
1/07 - 6/07 Product Line Manager, Battelle Biomedical Sciences and Technology (BS&T) and Director, Biomedical Research Center (BBRC), Columbus, OH
8/04 - 12/06 Manager of Non-clinical Research, Battelle Biomedical Research Center (BBRC), West Jefferson, OH
7/02 - 6/04 Commander, U.S. Army Center for Health Promotion and Preventive Medicine - Pacific, Headquartered at Camp Zama, Japan
5/97 - 6/02 Chief, Toxinology and Aerobiology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD
1/95 - 5/97 Biologics Product Manager/Toxicologist, Biological Systems Division, U.S. Army, Medical Materiel Development Activity, Fort Detrick, MD
7/94 - 10/94 Staff Officer-Special Project Intern, U.S. Army Medical Biological Defense Research Area Directorate, Fort Detrick, MD
9/93 - 1/95 Chief, Department of Physiology and Pharmacology, Toxinology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD
8/91 - 8/93 Principal Investigator, Toxinology Division, Department of Physiology and Pharmacology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD
8/88 - 8/91 Ph.D. Candidate, Toxicology: Department of Pharmacology, Toxicology and Therapeutics, Kansas University Medical Center, Kansas City, KS
9/86 - 8/88 Postdoctoral Associate Investigator, Pathophysiology Division, Cardio-respiratory Toxinology Department, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD
4/84 - 9/86 Officer in Charge, Team C, U.S. Army 106th Medical Detachment (VS), South Korea
8/82 - 4/84 Officer in Charge, Mather and McClellan Air Force Base Animal Disease Prevention and Control Programs, Mather Sacramento, CA

 
 

PROFESSIONAL AFFILIATIONS
 American Veterinary Medical Association
 New Mexico State Veterinary Medical Association
 Society of Phi Zeta, Kappa Chapter (Honor Society of Veterinary Medicine)
 Sigma Xi, the Scientific Research Society
 Society of Toxicology
 Western States Chapter, Society of Toxicology
 American College of Toxicology
 Association of Military Surgeons of the United States (AMSUS)


 
 AREAS OF RESEARCH
 Dr. LeClaire's primary research interests are in the pathophysiology of inhaled toxins and infectious agents, models for evaluation of surrogate endpoints of clinical efficacy, and correlates of protection for medical intervention. His experience includes work with biosafety level-2 and -3 (enhanced) agents, and management of chemical and biocontainment facilities.

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

 

REPRESENTATIVE PUBLICATIONS

  1. Pinson, D. M., R. D. LeClaire, R. B. Lorsbach, M. J. Parmely and S. W. Russell: Regulation by Transforming Growth Factor-Beta 1 of Expression and Function of the Receptor for IFN-Gamma on Mouse Macrophages. J. Immunol. 148(6): 2028-2034, 1992.

     

  2. Kell, W. M., R. D. LeClaire, M. B. Downs, R. Schmidt and M. Langford: A Rapid Immuno-chemiluminescent RT-PCR Method for Temporal Measurement of Induced Nitric Oxide Synthase mRNA in Macrophage and Endothelial Cells. Methods Mol. Cell Biol. 5: 105-111, 1995.

     

  3. LeClaire, R. D., W. M. Kell, R. A. Sadik, M. B. Downs and G. W. Parker: Regulation of Staphylococcal Enterotoxin B-Elicited Nitric Oxide Production by Endothelial Cells. Infect. Immun. 63(2): 539-546, 1995.

     

  4. LeClaire, R. D., G. W. Parker and D. R. Franz: Hemodynamic and Calorimeteric Changes Induced by Microcystin-LR in the Rat. J. Appl. Toxicol. 15(4): 303-311, 1995.

     

  5. LeClaire, R. D., R. E. Hunt, S. Bavari , J. E. Estep, G. O. Nelson and C. L. Wilhelmsen: Potentiation of Inhaled Staphylococcal Enterotoxin B-Induced Toxicity by Lipopolysaccharide in Mice. Toxicol. Pathol. 24(5): 619-626, 1996.

     

  6. LeClaire, R. D., W. Kell, S. Bavari, T. J. Smith and R. E. Hunt: Protective Effects of Niacinamide in Staphylococcal Enterotoxin-B-Induced Toxicity. Toxicology 107(1): 69-81, 1996.

     

  7. Bavari, S., R. G. Ulrich and R. D. LeClaire: Cross-reactive Antibodies Prevent the Lethal Effects of Staphylococcus aureus Superantigens. J. Infect. Dis. 180(4): 1365-1369, 1999.

     

  8. LeClaire, R. D. and S. Bavari: Human Antibodies to Bacterial Superantigens and Their Ability to Inhibit T-Cell Activation and Lethality. Antimicrob. Agents Chemother. 45(2): 460-463, 2001.

     

  9. LeClaire, R. D., R. E. Hunt and S. Bavari: Protection Against Bacterial Superantigen Staphylococcal Enterotoxin B by Passive Vaccination. Infect. Immun. 70(5): 2278-2281, 2002.

     

  10. Pitt, M. L. and R. D. LeClaire: The Aerosol Challenge: Animal Models for Testing Surrogate Endpoints of Clinical Efficacy. In Operational Medical Issues in Chemical and Biological Defense, Human Factors and Medicine Panel Symposium, North Atlantic Treaty Organization, Research and Technology Organization Meeting Proceedings, Vol. 75, p. 20-1-6, 2002.

     

  11. Boles, J. W., M. L. Pitt, R. D. LeClaire, P. H. Gibbs, E. Torres, B. Dyas, R. G. Ulrich and S. Bavari: Generation of Protective Immunity by Inactivated Recombinant Staphylococal Enterotoxin B Vaccine in Nonhuman Primates and Identification of Correlates of Immunity. Clin. Immunol. 108(1): 51-59, 2003.

     

  12. Boles, J. W., M. L. Pitt, R. D. LeClaire, P. H. Gibbs, R. G. Ulrich and S. Bavari: Correlation of Core Body Temperature with Protection Against Staphylococcal Enterotoxin B Exposure and Use in Determining Vaccine Dose-Schedule. Vaccine 21(21-22): 2791-2796, 2003.

     

  13. LeClaire, R. D.: Center for Health Promotion and Preventive Medicine, Pacific; Readiness through Health. U.S. Army Medical Department Journal, Oct/Nov/Dec: 7, 2003.

     

  14. Boles, J. W., M. West, V. Montgomery, R. Tammariello, M. L. Pitt, P. Gibbs, L. Smith and R. D. LeClaire: Recombinant C Fragment of Botulinum Neurotoxin B Serotype (rBoNTB (HC)) Immune Response and Protection in the Rhesus Monkey. Toxicon 47(8): 877-884, 2006.

     

  15. LeClaire, R. D. (contributor): Guidelines for Work with Toxins of Biological Origin. In CDC/NIH Biosafety in Microbiological and Biomedical Laboratories, 5th Edition, U.S., 2007.

     

  16. Millard, C. B. and R. D. LeClaire: Chapter 17, Ricin and Related Toxins: Review and Perspective. In Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology and Therapeutics (J. A. Romano, Jr., B. J. Lukey and H. Salem, eds.), 2nd Ed., pp. 423-468, CRC Press, Taylor & Francis Group, Boca Raton, FL, 2008.

     


 
 
 

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