EDUCATION
B.S./B.A. (Chemistry) 1955, Texas Christian University
Fulbright Scholar (Physical Chemistry) 1955-1956, Ludwig Maximillians
     Universitaet, Munich, Germany
Ph.D. (Chemistry) 1960, University of Texas
Rosalie B. Hite Fellow, 1956-1967, University of Texas
NIH Predoctoral Fellow, 1958-1960, University of Texas
NIH Postdoctoral Fellow, 1960-1962, University of Arkansas School of
     Medicine

PROFESSIONAL CERTIFICATION (by examination)
Diplomate, American Board of Toxicology, 1981

EMPLOYMENT

PROFESSIONAL AFFILIATION
Sigma Xi
American Association for the Advancement of Science
American Chemical Society
American Thoracic Society
New York Academy of Science
Society of Toxicology
Member, Research Committee of the Health Effects Institute, Boston, 1998-2005
Member, IOM Committee to Assess Science Base for Tobacco Harm Reduction,
     1999-2001
Member, NAS/NRC Committee on Estimating the Public Health Benefits of
     Proposed Air Pollution Regulations, 2000-2002
National Associate, National Academy of Sciences, 2001-Present
Member and Vice-Chair, Board of Scientific Counselor (BOSC), US EPA,
     2002-Present
Chair, Clean Air Scientific Advisory Committee (CASAC), US EPA, 2004-2006
Chair, NAS/NRC Committee on Assessing Human Health Risks of
     Trichloroethylene, 2004-Present
Chair, BOSC Symposium on Risk Assessment Practices of the EPA, 2004
Chair, BOSC Review Panel for the US EPA PM/O3 Research Program, 2005
Co-Chair, World Health Organization's Task Group on Environmental Health
     Criteria for Bentonite, Kaolin and Selected Clay Minerals, 2005
Member, IOM Committee on Asbestos: Selected Health Effects, 2005-Present

AREAS OF RESEARCH
Dr. Henderson has research interests in two major areas. She has had a long-term interest in the biochemistry of the lung, particularly the surfactant lining layer. She has developed in vivo screening tests for pulmonary toxicants based on analysis of bronchoalveolar washings. A second area of interest is the pharmacokinetics of inhaled xenobiotics (particularly vapors) and their metabolites. In both areas, Dr. Henderson has studied the use of biological markers of exposure and of effects to link environmental exposure to induced disease. Her recent studies are on the health effect of exposure to low levels of sarin gas. 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

REPRESENTATIVE PUBLICATIONS

1. Henderson, R. F., W. E. Bechtold, J. R. Thornton-Manning and A. R. Dahl: Urinary Butadiene Diepoxide: A Potential Biomarker of Blood Diepoxide. Toxicology 160(1-3): 81-86, 2001.
2. Meng, Q., R. F. Henderson, L. Long, L. Blair, D. M. Walker, P. B. Upton, J. A. Swenberg and V. E. Walker: Mutagenicity at the Hprt Locus in T Cells of Female Mice Following Inhalation Exposures to Low Levels of 1,3-Butadiene. Chem. Biol. Interact. 135-136: 343-361, 2001.

    

3. Conn, C. A., K. Dokladny, M. G. Ménache, E. B. Barr, W. Kozak, A. Kozak, M. Wachulec, K. Rudolph, M. J. Kluger and R. F. Henderson: Effects of Sarin on Temperature and Activity of Rats as a Model for Gulf War Syndrome Neuroregulatory Functions. Toxicol. Appl. Pharmacol. 184(2): 77-81, 2002.

    

4. Henderson, R. F., E. B. Barr, W. B. Blackwell, C. R. Clark, C. A. Conn, R. Kalra, T. H. March, M. L. Sopori, Y. Tesfaigzi, M. G. Ménache and D. C. Mash: Response of Rats to Low Levels of Sarin. Toxicol. Appl. Pharmacol. 184(2): 67-76, 2002.

    

5. Kalra, R., S. P. Singh, S. Razani-Boroujerdi, R. J. Langley, W. B. Blackwell, R. F. Henderson and M. L. Sopori: Subclinical Doses of the Nerve Gas Sarin Impair T Cell Responses Through the Autonomic Nervous System.Toxicol. Appl. Pharmacol. 184(2): 82-87, 2002.

    

6. McDonald, J. D., W. E. Bechtold, J. R. Krone, W. B. Blackwell, D. A. Kracko and R. F. Henderson: Analysis of Butadiene Urinary Metabolites by Liquid Chromatography–Triple Quadrupole Mass Spectrometry. J. Anal. Toxicol. 28: 168-173, 2004.

    

7. Henderson, R. F.: Use of Bronchoalveolar Lavage to Detect Respiratory Tract Toxicity of Inhaled Material. Exp. Toxicol. Pathol. 57(Suppl. 1): 155-159, 2005.

    

8. Henderson, R. F., J. Stewart, G. P. Daston, C. S. Duke and W. Farland: EPA Risk Assessment Principles and Practices. BOSC (Board of Scientific Counselors) Workshop, February 2-3, 2005, Washington, DC. Environ. Sci. Pollut. Res. Int. 12(6): 388-390, 2005.

    

9. Henderson, R. F., M. Gurule, B. M. Hedtke-Weber, K. Ghanbari, J. D. McDonald, D. A. Kracko and K. J. Dix: Disposition of Orally and Intravenously Administered Methyltetrahydrofuran in Rats and Mice. J. Toxicol. Environ. Health A 70(7): 582-593, 2007.

    

10. Meng, Q., D. M. Walker, J. D. McDonald, R. F. Henderson, M. M. Carter, D. L. Cook, Jr., C. L. McCash, S. M. Torres, M. J. Bauer, S. K. Seilkop, P. B. Upton, N. I. Georgieva, G. Boysen, J. A. Swenberg and V. E. Walker: Age-, Gender-, and Species-Dependent Mutagenicity in T Cells of Mice and Rats Exposed by Inhalation to 1,3-Butadiene. Chem. Biol. Interact. 166(1-3): 121-131, 2007.

     

11. Pena-Philippides, J. C., S. Razani-Boroujerdi, S. P. Singh, R. J. Langley, N. C. Mishra, R. F. Henderson and M. L. Sopori: Long- and Short-Term Changes in the Neuroimmune-Endocrine Parameters Following Inhalation Exposures of F344 Rats to Low-Dose Sarin. Toxicol. Sci. 97(1): 181-188, 2007.

     

12. Walker, D. M., J. D. McDonald, Q. Meng, D. A. Kracko, M. J. Bauer, S. K. Seilkop, E. L. Walker, R. F. Henderson and V. E. Walker: Measurement of Plasma or Urinary Metabolites and Hprt Mutant Frequencies Following Inhalation Exposure of Mice and Rats to 3-Butene-1,2-diol. Chem. Biol. Interact. 166(1-3): 191-206, 2007.