Crowell, Richard E., MD

EDUCATION

B.S. (Zoology/Comparative Literature) 1975, The Ohio State University
M.D. (Medicine) 1979, University of Cincinnati College of Medicine

 

CERTIFICATION
Diplomate, National Board of Medical Examiners, 1980
Diplomate, American Board of International Medicine, Specialty: Internal
     Medicine, 1982; Subspecialty: Pulmonary Medicine, 1986; Subspecialty:
     Critical Care Medicine, 1989

 

EMPLOYMENT

2002 - Present Adjunct Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - Present Chief, Division of Pulmonary and Critical Care, University of New Mexico School of Medicine, Albuquerque, NM
2001 - Present Professor of Medicine, University of New Mexico School of Medicine, Albuquerque, NM
1995 - 2001 Associate Professor of Medicine, University of New Mexico School of Medicine, Albuquerque, NM
1994 - 2002 Adjunct Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
1993 - Present Chief, Pulmonary and Critical Care Section, Veterans Administration Medical Center, Albuquerque, NM
1991 - 1995 Assistant Professor of Medicine, University of New Mexico School of Medicine
1987 - 1991 Research Assistant Professor of Medicine, University of New Mexico School of Medicine
1985 - 1987 Instructor, Department of Medicine, University of New Mexico School of Medicine
1983 - 1985 Fellow, Pulmonary/Critical Care, University of New Mexico School of Medicine
1979 - 1983 Intern, Resident, Chief Resident, Internal Medicine, Baystate Medical Center, Springfield, MA


 

PROFESSIONAL AFFILIATIONS
American College of Chest Physicians
American Thoracic Society
International Association for the Study of Lung Cancer
American Association for Cancer Research
American Lung Association 



AREAS OF RESEARCH
Dr. Crowell's primary research interests are in prevention, diagnosis, and treatment of lung cancer, particularly in identification, development, and testing of biomarkers for lung carcinogenesis and in developing other measures of lung cancer risk, such as individual lung cancer susceptibility. The long-term goal of these interests is to assess disease risk, improve early detection, evaluate the efficacy of interventions designed to disrupt carcinogenesis, and prognostication. As one of a group of collaborating scientists from LRRI, UNM, and the Albuquerque VA Medical Center, Dr. Crowell is currently investigating molecular markers of respiratory carcinogenesis in bronchial epithelial cells collected during bronchoscopy and within expectorated sputum. He is also interested in novel methods for diagnosis, evaluation, and treatment of lung cancer. 


 

REPRESENTATIVE PUBLICATIONS

  1. Weissman, D. N., D. E. Bice, R. E. Crowell and M. R. Schuyler: Intrapulmonary Antigen Deposition in the Human Lung: Local Responses. Am. J. Respir. Cell Mol. Biol. 11: 607-614, 1994.

     

  2. Abraham, E., R. Wunderink, H. Silverman, T. M. Perl, S. Nasraway, H. Levy, R. Bone, R. P. Wenzel, R. Balk, R. Alfred, J. E. Pennington and J. C. Wherry; for the TNFa Mab Sepsis Study Group (R. E. Crowell, Co-investigator): Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor-a in Patients with Sepsis Syndrome. JAMA 273: 934-941, 1995.

     

  3. Crowell, R. E., G. Hallin, E. Heaphy and C. Mold: Hyperoxic Suppression of Fcg Receptor-Mediated Phagocytosis by Isolated Murine Pulmonary Macrophages. Am. J. Respir. Cell Mol. Biol. 12: 190-195, 1995.

     

  4. Crowell, R. E. and J. M. Samet: Commentary: Why Does the White Blood Cell Count Predict Mortality? Am. J. Epidemiol. 142: 499-501, 1995.

     

  5. Crowell, R. E.: Hemoptysis. In Medicine, A Primary Care Approach (R. H. Rubin, C. Voss, D. J. Derkson, A. Gateley and R. W. Quenzer, eds.), pp. 112-115, W. B. Saunders Co., Philadelphia, PA, 1996.

     

  6. Crowell, R. E., E. Heaphy, R. E. Neft, F. D. Gilliland, R. T. Temes, D. Auckley, J. F. Lechner and S. A. Belinsky: Detection of the Presence of Trisomy 7 in Normal Bronchial Epithelium in Subjects at Risk for Lung Cancer. Cancer Epidemiol. Biomarkers Prev. 5: 631-737, 1996.

     

  7. Hallin, G. W., S. Q. Simpson, R. E. Crowell, D. S. James, F. T. Koster, G. J. Mertz and H. Levy: Cardiopulmonary Manifestations of the Hantavirus Pulmonary Syndrome. Crit. Care Med. 24: 252-258, 1996.

     

  8. Mapel, D., R. Fei and R. E. Crowell: Adenocarcinoma of the Lung Presenting as a Diffuse Interstitial Process in a 25 Year Old Man. Lung Cancer 15: 239-244, 1996.

     

  9. Crowell, R. E. and S. A. Belinsky: Genetic Changes of Lung Cancer: Potential Biomarkers for Early Detection and Prevention (Invited Review). J. Lab. Clin. Med. 130: 550-557, 1997.

     

  10. Tierney, L. A., R. E. Neft, S. Belinsky, F. T. Lauer, F. D. Gilliland, R. E. Crowell and J. F. Lechner: Double-Label Suspension Immunohistochemistry for Detection of Gene Dysfunction in Sputum. J. Histotechnol. 20(1): 13-17, 1997.

     

  11. Crowell R. E. and S. A. Belinsky: Markers of Lung Carcinogenesis in Bronchial Epithelium. A Case Control Study to Determine Outcome of Genetic Abnormalities in Nonmalignant Bronchial Epithelium: Probable Progression to Cancer? Current Clinical Trials in Thoracic Oncology 2: 10, 1998.

     

  12. Lechner, J. F., R. E. Neft, F. D. Gilliland, R. E. Crowell, D. H. Auckley, R. T. Temes and S. A. Belinsky: Individuals at High Risk for Lung Cancer Have Airway Epithelial Cells with Chromosome Aberrations Frequently Found in Lung Tumor Cells. In Vivo 12: 23-26, 1998.

     

  13. Neft, R. E., R. E. Crowell, F. D. Gilliland, M. M. Murphy, J. L. Lane, H. Harms, T. Coons, E. Heaphy, S. A. Belinsky and J. F. Lechner: Frequency of Trisomy 20 in Nonmalignant Bronchial Epithelium from Lung Cancer Patients and Cancer-Free Former Uranium Miners and Smokers. Cancer Epidemiol. Biomarkers Prev. 7: 1051-1054, 1998.

     

  14. Auckley, D. H., R. E. Crowell, E. R. Heaphy, C. A. Stidley, J. F. Lechner, F. D. Gilliland and S. A. Belinsky: Reduced DNA-Dependent Protein Kinase Activity is Associated with Lung Cancer. Carcinogenesis 22: 723-727, 2001.

     

  15. Divine, K. K., F. D. Gilliland, R. E. Crowell, C. A. Stidley, T. J. Blocklage, D. L. Cook and S. A. Belinsky: The XRCC1 399 Glutamine Allele is a Risk Factor for Adenocarcinoma of the Lung. Mutat. Res. 461: 273-278, 2001.

     

  16. Belinsky, S. A., W. A. Palmisano, F. D. Gilliland, L. A. Crooks, K. K. Divine, S. A. Winters, M. J. Grimes, H. J. Harms, C. S. Tellez, T. M. Smith, P. P. Moots, J. F. Lechner, C. A. Stidley and R. E. Crowell: Aberrant Promoter Methylation in Bronchial Epithelium and Sputum from Current and Former Smokers.Cancer Res. 62: 2370-2377, 2002.

     

  17. Gilliland, F. D., H. J. Harms, R. E. Crowell, Y.-F. Li, R. Willink and S. A. Belinsky: Glutathione S-Transferase P1 and NADPH Quinone Oxidoreductase Polymorphisms are Associated with Aberrant Promoter Methylation of P16INK4a and O6-Methylguanine-DNA Methyltransferase in Sputum. Cancer Res. 62: 2248-2252, 2002.

     

  18. Magana, E. and R. E. Crowell: Radiation Pneumonitis Successfully Treated with Inhaled Corticosteroids. Southern Medical Journal 96: 521-524, 2003.

     

  19. Belinsky, S. A., D. M. Klinge, J. D. Dekker, M. W. Smith, T. J. Bocklage, F. D. Gilliland, R. E. Crowell, D. D. Karp, C. A. Stidley and M. A. Picchi: Gene Promoter Methylation in Plasma and Sputum Increases with Lung Cancer Risk. Clin. Cancer Res. 11: 6505-6511, 2005.

     

  20. Tesfaigzi, Y., O. B. Myers, C. A. Stidley, K. Schwalm, M. Picchi, R. E. Crowell, F. D. Gilliland and S. A. Belinsky: Genotypes in Matrix Metalloproteinase 9 are a Risk Factor for COPD. Int. J. COPD 1(3): 267-268, 2006.
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