Moseley, Pope L., MD

EDUCATION
B.S. (Chemistry) 1976, Davidson College
M.D. (Medicine) 1980, University of Illinois College of Medicine
M.S. (Preventive Medicine) 1983, University of Illinois College of Medicine

 

EMPLOYMENT


2002 - Present Adjunct Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - Present Chair, Department of Internal Medicine, University of New Mexico, Albuquerque, NM
1997 - 2002 Adjunct Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
1997 - Present Professor, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM
1995 - Present Professor and Chief, Pulmonary and Critical Care Division, Department of Internal Medicine, University of New Mexico
1990 - 1995 Associate Professor, Departments of Exercise Sciences and Internal Medicine, University of Iowa, Iowa City, IA
1986 - 1990 Assistant Professor, Department of Internal Medicine, University of Iowa
1985 - 1986 Instructor, Department of Internal Medicine, University of Iowa
1983 - 1985 Fellow, Pulmonary Medicine, Department of Internal Medicine, University of Iowa
1981 - 1983 Research Resident, Internal Medicine, University of Iowa
1980 - 1981 Internship, Department of Internal Medicine, University of Iowa Hospitals and Clinics

 

AREAS OF RESEARCH
     Dr. Moseley's research focuses on the role of the cellular heat shock protein (HSP) response in the adaptation of the whole organism. In the intracellular environment, the HSPs serve as protein transporters and are associated with tolerance to a variety of stresses. His group was the first research group to demonstrate that alterations in cellular HSP accumulation occur in humans under physiologic conditions, and were the first to demonstrate that a conditioning heat stress sufficient to cause HSP accumulation protects the whole organism from endotoxin exposure. Dr. Moseley's research group has shown that oxidants differentially regulate the heat shock response, and that the previously observed inability of aged organisms to accumulate HSP70 following heat stress reflects an alteration in gene regulation rather than a loss of potential to produce HSP70. Using both cellular systems and studies in the intact organism, his research group has identified gut injury and the loss of epithelial barrier integrity as early and perhaps pivotal events in the pathogenesis of heat stress.

     In contrast to the stress tolerance associated with intracellular HSP accumulation, HSPs seen in the local extracellular environment-either on the cell surface or released from injured cells-activate a potent immune/inflammatory response. HSP70 found on the surface of certain cells, principally tumor cells and virus-infected cells, is associated with Natural Killer cell killing. In addition, vaccines composed of HSP-tumor peptide complexes have shown promise in the generation of a specific cytotoxic T-lymphocyte response to implanted tumors in animals. Dr. Moseley's laboratory has focused on the mechanism of HSP70 mediated tumor cell recognition and on the development of HSP70-peptide complexes as vaccines. The patents on methods to purify and synthesize these HSP-peptide complexes will allow the group to conduct a variety of studies on the immune response to tumors, and make possible a number of studies and potential treatment applications.

     Finally, his group has developed a paradigm to reconcile the seeming dichotomy of intracellular HSPs as cellular protectors and extracellular HSPs as inflammatory activators, which is based on the demonstration that HSPs are essential for the replication of the CELO adenovirus, providing an evolutionary rationale for the immune-activating effects of extracellular HSPs an adaptive response to this viral HSP requirement.

 

REPRESENTATIVE PUBLICATIONS

  1. Iwamoto, G. K., A. M. Ainsworth and P. L. Moseley: Hyperthermia Enhances Cytomegalovirus Regulation of HIV-1 and TNF-a Gene Expression. Am. J. Physiol. 277(5 Pt 1): L1051-L1056, 1999.

     

  2. Glotzer, J. B., M. Saltik, S. Chiocca, A. I. Michou, P. Moseley and M. Cotten: Activation of Heat-Shock Response by an Adenovirus is Essential for Virus Replication. Nature 407(6801): 207-211, 2000.

     

  3. Hall, D. M., T. D. Oberley, P. L. Moseley, G. R. Buettner, L. W. Oberley, R. Weindruch and K. C. Kregel: Caloric Restriction Improves Thermotolerance and Reduces Hyperthermia-Induced Cellular Damage in Old Rats. FASEB J. 14: 780-786, 2000.

     

  4. Hall, D. M., L. Xu, V. J. Drake, L. W. Oberley, T. D. Oberley, P. L. Moseley and K. C. Kregel: Aging Reduces Adaptive Capacity and Stress Protein Expression in the Liver After Heat Stress. J. Appl. Physiol. 89: 749-759, 2000.

     

  5. Moseley, P. L.: Exercise, Stress, and the Immune Conversation. Exerc. Sport Sci. Rev. 28(3): 128-132, 2000.

     

  6. Moseley, P.: Stress Proteins and the Immune Response. Immunopharmacology 48: 299-302, 2000.

     

  7. Dokladny, K., A. Kozak, M. Wachulec, E. S. Wallen, M. G. Ménache, W. Kozak, M. J. Kluger and P. L. Moseley: Effect of Heat Stress on LPS-Induced Febrile Response in D-Galactosamine-Sensitized Rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280(2): R338-R344, 2001.

     

  8. Walsh, R. C., I. Koukoulas, A. Garnham, P. L. Moseley, M. Hargreaves and M. A. Febbraio: Exercise Increases Serum Hsp75 in Humans. Cell Stress Chaperones 6(4): 386-393, 2001.

     

  9. Lambert, G. P., C. V. Gisolfi, D. J. Berg, P. L. Moseley, L. W. Oberley and K. C. Kregel: Selected Contribution: Hyperthermia-Induced Intestinal Permeability and the Role of Oxidative and Nitrosative Stress. J. Appl. Physiol. 92(4): 1750-1761, 2002.

     

  10. Roigas, J., E. S. Wallen, S. A. Loening and P. L. Moseley: Estramustine Phosphate Enhances the Efffects of Hyperthermia and Induces the Small Heat Shock Protein HSP27 in the Human Prostate Carcinoma Cell Line PC-3. Urol. Res. 30(2): 130-135, 2002.

     

  11. Harkins, M. S., P. L. Moseley and G. K. Iwamoto: Regulation of CD23 in the Chronic Inflammatory Response in Asthma: A Role for Interferon-gamma and Heat Shock Protein 70 in the TH2 Environment. Ann. Allergy Asthma Immunol. 91(6): 567-574, 2003.

     

  12. Roigas, J., C. A. Jensen, E. S. Wallen, S. A. Loening, W. Wharton and P. L. Moseley: Repression of Thermotolerance in Dunning R3327 Prostate Carcinoma Cells by 2-Deoxy-glucose. Int. J. Hyperthermia 20(6): 557-566, 2004.

     

  13. Savell, J., Y. Ma, K. S. Morrow, R. Jove, N. Olashaw, P. L. Moseley, W. D. Cress and W. Wharton: AG490 Inhibits G1-S Traverse in BALB/c-3T3 Cells Following Either Mitogenic Stimulation or Exogenous Expression of E2F-1. Mol. Cancer Ther. 3(2): 205-213, 2004.

     

  14. Raj, D. S., E. A. Dominic, A. Pai, F. Osman, M. Morgan, G. Pickett, V. O. Shah, A. Ferrando and P. Moseley: Skeletal Muscle, Cytokines, and Oxidative Stress in End-stage Renal Disease. Kidney Int. 68(5): 2338-2344, 2005.

     

  15. Dokladny, K., P. L. Moseley and T. Y. Ma: Physiologically Relevant Increase in Temperature Causes an Increase in Intestinal Epithelial Tight Junction Permeability. Am. J. Physiol. Gastrointest. Liver Physiol. 290(2): G204-G212, 2006.

     

  16. Dokladny, K., W. Wharton, R. Lobb, T. Y. Ma and P. L. Moseley: Induction of Physiological Thermotolerance in MDCK Monolayers: Contribution of Heat Shock Protein 70. Cell Stress Chaperones 11(3): 268-275, 2006.

     

  17. Melendez, K., E. S. Wallen, B. S. Edwards, C. D. Mobarak, D. G. Bear and P. L. Moseley: Heat Shock Protein 70 and Glycoprotein 96 are Differentially Expressed on the Surface of Malignant and Nonmalignant Breast Cells. Cell Stress Chaperones 11(4): 334-342, 2006.

     

  18. Popko, K. and P. Moseley: The Public Perception Proejct. A Research-Tested Way to Talk About the Ministry. Health Prog. 87(1): 7-9, 2006.

     

  19. Shah, V. O., E. A. Dominic, P. Moseley, G. Pickett, M. Fleet, S. Ness and D. S. Raj: Hemodialysis Modulates Gene Expression Profile in Skeletal Muscle. Am. J. Kidney Dis. 48(4): 616-628, 2006.
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