EDUCATION
B.A. (Biochemistry) 2002, Hamline University
Ph.D. (Major: Pharmaceutical Sciences, Minor: Analytical Chemistry) 2007, The University of Arizona 

EMPLOYMENT

PROFESSIONAL AFFILIATIONS
American Association of Pharmaceutical Scientists
Association of Inhalation Toxicologists
American Chemical Society 

AREAS OF RESEARCH
In graduate school Dr. Kuehl conducted research in the areas of preformulation, formulation and evaluation of formulations for delivery of small molecules. Specifically, these research experiences included solubility measurement, stability determination, and utilization of different solubilization techniques to increase solubility, solid state drug characterization, formulation development, in vivo evaluation and PK analysis of developed formulations. A portion of Dr. Kuehl’s work was conducted in collaboration with the Arizona Cancer Center in developing topical formulations for clinically evaluating new agents for chemoprevention of skin cancer. At Lovelace Dr. Kuehl utilizes his experience in formulation development to create, characterize and optimize formulations of potential active pharmaceutical ingredients for inhalation drug delivery from a wide range of devices. Of particular interest to Dr. Kuehl is the work conducted in the LRRI Imaging facility. In this capability Dr. Kuehl works to utilize advances in imaging to explore deposition and biodistribution of radiolabeled materials in different test systems. Dr. Kuehl also manages Lovelace’s Chemistry department which includes analytical chemistry and bioanalytical chemistry. 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

REPRESENTATIVE PUBLICATIONS

1. Kuehl, P. J., M. D. Carducci and P. B. Myrdal: An Ethanol Solvate of Beclomethasone Dipropionate. Acta Cryst. E E59: o1888-o1890, 2003.

    

2. Kuehl, P., B. S. Angersbach, S. P. Stratton and P. B. Myrdal: Development of an HPLC Method for the Analysis of Apomine in a Topical Cream Formulation. J. Pharm. Biomed. Anal. 40(4): 975-980, 2006.

    

3. Kuehl, P. J., M. D. Carducci and P. B. Myrdal: 4-Imino-1,3-diazabicyclo[3.1.0]hexan-2-one. Acta Cryst. E E62: o3688-o3690, 2006.

    

4. Kuehl, P. J., W. L. Hoye and P. B. Myrdal: Performulation Studies on Imexon. Drug Dev. Ind. Pharm. 32(6): 687-697, 2006.

    

5. Myrdal, P. B., B. S. Angersbach, K. Karlage and P. J. Kuehl: Chiral Separation of Lipoxygenase Metabolites Utilizing High-Performance Liquid Chromatography. J. Chromatogr. A 1132(1-2): 315-319, 2006.

    

6. Mogalian, E., P. J. Kuehl and P. B. Myrdal: New Analytical Techniques to Facilitate Preformulation Screening in Propellant Systems. Int. J. Pharm. 340(1-2): 223-229, 2007.

    

7. Myrdal, P. B., K. Karlage, P. J. Kuehl, B. S. Angersbach, B. A. Merrill and P. D. Wightman: Effects of Novel 5-Lipoxygenase Inhibitors on the Incidence of Pulmonary Adenomas in the A/J Murine Model when Administered via Nose-Only Inhalation. Carcinogenesis 28(5): 957-961, 2007.

    

8. Cheng, Y. S., H. Irshad, P. Kuehl, T. D. Holmes, R. Sherwood and C. H. Hobbs: Lung Deposition of Droplet Aerosols in Monkeys. Inhal. Toxicol. 20(11): 1029-1036, 2008.

    

9. Kuehl, P. J., T. Brenner, P. K. Jain, K. Karlage, K. Sepassi, G. Yang, M. Mayersohn, S. H. Yalkowsky and P. B. Myrdal: Formulation and In Vivo Evaluation of Chlorpropham (CIPC) Oral Formulations. J. Pharm. Sci. Mar 27 [Epub ahead of print], 2008.

    

10. Kuehl, P. J., Y. S. Cheng, T. Holmes, H. Irshad, C. L. Leach and J. D. McDonald: Regional Deposition Analysis of a Technetium-99m Labeled Aerosol to Anesthetized Non Human Primates by Planar Gamma Camera Imaging. In Proceedings of Respiratory Drug Delivery 2008, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 601-604, Virginia Commonwealth University, Richmond, VA, 2008.

     

11. Kuehl, P. J., K. Karlage, T. Brenner and P. B. Myrdal: Determining the Effect of Carbendazim and Paclitaxel, Dosed Orally and via Inhalation, on Pulmonary Adenomas in the A/J Mouse Model. In Proceedings of Respiratory Drug Delivery 2008, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 605-610, Virginia Commonwealth University, Richmond, VA, 2008.

     

12. Vodak, D. T., D. E. Dobry, P. J. Kuehl, M. Doyle-Eisele, J. D. McDonald, A. Silcock, G. Magee, D. Pole, W. K. Miller, D. Friesen and D. K. Lyon: Platform Formulation Development Utilizing a Novel Pulmonary Excipient and In Vivo Evaluation of Engineered Particles of Fluticasone Propionate as a Model Formulation. In Proceedings of Respiratory Drug Delivery 2009, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 251-254, Virginia Commonwealth University, Richmond, VA, 2009.

     

13. Kuehl, P. J., S. P. Stratton, M. B. Powell and P. B. Myrdal: Preformulation, Formulation and In Vivo Efficacy of Apomine. Int. J. Pharm. (in press).