MISHRA, NEERAD C., PHD

EDUCATION
 B.S. (Biology) 1983, Allahabad University, India
 M.S. (Biochemistry) 1985, Allahabad University, India
 Ph.D. (Chemistry/Biochemistry) 1992, Kanpur University, India
 


 

 

EMPLOYMENT

2009 - Present Associate Staff Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2002 - Present Clinical Associate Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
2002 - 2009 Associate Research Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - 2002 Associate Research Scientist, Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1999 - 9/01 Postdoctoral Fellow, Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1992 - 1999 Research Officer, Malaria Research Center, Delhi, India
1987 - 1992 Junior & Senior Research Fellow, Central Drug Research Institute, Lucknow, India

AWARDS/FELLOWSHIPS
 Postdoctoral Fellowship, Lovelace Respiratory Research Institute, Albuquerque, NM
 Junior & Senior Research Fellowships, Indian Council of Medical Research, New Delhi, India
 Senior Research Fellowship of Ministry, Health & Family Welfare, New Delhi, India
 Fellow of Indian Society for Malaria and Other Communicable Diseases


 
 

PROFESSIONAL AFFILIATIONS
 The American Association of Immunologists
 American Thoracic Society
 American Society for Biochemistry and Molecular Biology
 Federation of American Societies for Experimental Biology
 Indian Society for Parasitology


 
 AREAS OF RESEARCH
 The major areas of Dr. Mishra's research are 1) Effect of cigarette smoke/nicotine on allergic asthma, and 2) Mechanism of sulfur mustard-induced injury in animal models.

 

  • Role of Cigarette Smoke/Nicotine in Regulating Mucus Production
     Dr. Mishra’s lab recently reported that nicotine exacerbates mucus formation in allergic rats, in spite of decreased Th2 cytokines. Preliminary evidence suggests that in human airway epithelial cells, nicotine strongly upregulates mucus formation and GABAAR expression. His lab is currently exploring the mechanism by which nicotine modifies the mucus response in these cells and its relevance to COPD.

     

  • Prenatal Exposure to Cigarette Smoke (CS) and Allergic Asthma
     Prevalence of asthma, particularly among children, is steadily increasing worldwide. Epidemiological studies suggest that CS during pregnancy is a risk factor in the development of childhood asthma and atopy. However, the mechanism by which in utero CS exposure affects lung function and elevates the risk of childhood asthma is largely unknown. We are exploring the hypothesis that exposure to CS during embryogenesis downregulates the density of nAChRs, and/or tolerizes nAChRs, and/or increases mAChRs.

     

  • Mechanism of Sulfur Mustard-Induced Delayed Response and Injury
     Sulfur mustard (SM), the highly reactive alkylating agent, was used as a chemical warfare agent in World War I and the1980’s Iraq/Iran conflict. SM is a potential threat to both military and civilian targets, and exposure to SM is known to cause delayed respiratory impairment. The mechanism by which SM induced delayed respiratory complications is not clear. His lab is examining the hypothesis that SM, being a strong alkylating agent, alters the major histocompatibility antigens, leading to an allogenic-type of response to the SM-modified “altered self”, thereby inducing an autoimmune type of a response.

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED


 
 

REPRESENTATIVE PUBLICATIONS

  1. Sharma, A. and N. C. Mishra: Inhibition of Protein Tyrosine Kinase Activity in Plasmodium falciparum by Chloroquine. Ind. J. Biochem. Biophys. 36(5): 299-304, 1999.

     

  2. Ito, Y., N. C. Mishra, K. Yoshida, S. Kharbanda, S. Saxena and D. W. Kufe: Mitochondrial Targeting of JNK/SAPK in the Phorbol Ester Response of Myeloid Leukemia Cells. Cell Death Differ. 8(8): 794-800, 2001.

     

  3. Ito, Y.*, P. Pandey*, N. Mishra*, S. Kumar, N. Narula, S. Kharbanda, S. Saxena and D. Kufe: Targeting of c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced Apoptosis. Mol. Cell. Biol. 21(18): 6233-6242, 2001. * These authors contributed equally in this work.

     

  4. Kumar, S., A. Bharti, N. C. Mishra, D. Raina, S. Kharbanda, S. Saxena and D. Kufe: Targeting of the c-Abl Tyrosine Kinase to Mitochondria in the Necrotic Cell Death Response to Oxidative Stress. J. Biol. Chem. 276(20): 17281-17285, 2001.

     

  5. Majumder, P., N. C. Mishra, X. Sun, A. Bharti, S. Kharbanda, S. Saxena and D. Kufe: Targeting of Protein Kinase C delta to Mitochondria in the Oxidative Stress Response. Cell Growth Differ. 12(9): 465-470, 2001.

     

  6. Raina, D., N. Mishra, S. Kumar, S. Kharbanda, S. Saxena and D. Kufe: Inhibition of c-Abl with ST1571 Attenuates Stress-Activated Protein Kinase Activation and Apoptosis in the Cellular Response to 1-b-D-Arabinofuranosylcytosine. Mol. Pharmacol. 61(6): 1489-1495, 2002.

     

  7. Kumar, S., N. Mishra, D. Raina, S. Kharbanda, S. Saxena and D. Kufe: Abrogation of the Cell Death Response to Oxidative Stress by the c-Abl Tyrosine Kinase Inhibitor ST1571. Mol. Pharmacol. 63: 276-282, 2003.

     

  8. Langley, R. J., R. Kalra, N. C. Mishra, F. F. Hahn, S. Razani-Boroujerdi, S. P. Singh, J. M. Benson, J. C. Pena-Philippides, E. B. Barr and M. L. Sopori: A Biphase Response to Silica. I. Immunostimulation is Restricted to the Early Stage of Silicosis in Lewis Rats. Am. J. Respir. Cell Mol. Biol. 30(6): 823-829, 2004.

     

  9. Langley, R. J., R. Kalra, N. C. Mishra and M. L. Sopori: Central But Not the Peripheral Action of Cholinergic Compounds Suppresses the Immune System. J. Neuroimmunol. 148(1-2): 140-145, 2004.

     

  10. Mishra, N. C. and S. Kumar: Apoptosis: A Mitochondrial Perspective on Cell Death. Ind. J. Exp. Biol. 43(1): 25-34, 2005.

     

  11. Singh, S. P., S. Razani-Boroujerdi, J. C. Pena-Philippides, R. J. Langley, N. C. Mishra and M. L. Sopori: Early Postnatal Exposure to Cigarette Smoke Impairs the Antigen-Specific T-Cell Responses in the Spleen. Toxicol. Lett. 167(3): 231-237, 2006.

     

  12. Pena-Philippides, J. C., S. Razani-Boroujerdi, S. P. Singh, R. J. Langley, N. C. Mishra, R. F. Henderson and M. L. Sopori: Long- and Short-Term Changes in the Neuroimmune-Endocrine Parameters Following Inhalation Exposures of F344 Rats to Low-Dose Sarin. Toxicol. Sci. 97(1): 181-188, 2007.

     

  13. Razani-Boroujerdi, S., R. T. Boyd, M. I. Davila-Garcia, J. S. Nandi, N. C. Mishra, S. P. Singh, J. C. Philippides, R. Langley and M. L. Sopori: T Cells Express a7-Nicotinic Acetylcholine Receptor Subunits that Require a Functional TCR and Leukocyte-Specific Tyrosine Kinase for Nicotine-Induced Ca2+ Response. J. Immunol. 179(5): 2889-2898, 2007.

     

  14. Mishra, N. C., J. Rir-Sima-ah, R. J. Langley, S. P. Singh, J. C. Peña-Philippides, T. Koga, S. Razani-Boroujerdi, J. Hutt, M. Campen, K. C. Kim, Y. Tesfaigzi and M. L. Sopori: Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens. J. Immunol. 180(11): 7655-7663, 2008.

     

  15. Singh, S. P., N. C. Mishra, J. Rir-sima-ah, M. Campen, V. Kurup, S. Razani-Boroujerdi and M. L. Sopori: Maternal Exposure to Secondhand Cigarette Smoke Primes the Lung for Induction of Phosphodiesterase4D5 Isozyme and Exacerbated Th2 Responses; Rolipram Attenuates the Airway Hyperreactivity and Muscarinic Receptor Expression but not Lung Inflammation and Atopy. J. Immunol. 183(3): 2115-2121, 2009.

     

  16. Langley, R. J., N. C. Mishra, J. C. Peña-Philippides, S. Razani-Boroujerdi, J. A. Hutt and M. L. Sopori. 2009. Granuloma Formation Induced by Low-Dose Chronic Silica inhalation is Associated with an Anti-Apoptotic Response in Lewis Rats. J. Toxicol. Environ. Health A 73(10): 669-683, 2010.

     

  17. Mishra, N. C., J. Rir-sima-ah, R. T. Boyd, S. P. Singh, S. Gundavarapu, R. J. Langley, S. Razani-Boroujerdi and M. L Sopori: Nicotine Inhibits FceRI-Induced Cysteinyl Leukotrienes and Cytokine Production Without Affecting Mast Cell Degranulation Through a7/a9/a10-Nicotinic Receptors. J. Immunol. 185(1): 588-596, 2010.

     

  18. Mishra, N. C., J. Rir-Sim-Ah, T. March, W. Weber, J. Benson, R. Jaramillo, JC. Seagrave, G. Schultz, G. Grotendorst and M. Sopori: Sulfur Mustard Induces Immune Sensitization in Hairless Guinea Pigs. Int. Immunopharmacol. 10(2): 193-199, 2010.

     

  19. 1.        Razani-Boroujerdi, S., R. J. Langley, S. P. Singh, R. Kalra, J. C. Philippides, J. Rir‑sima‑ah, S. Gundavarapu, N. Mishra and M. L. Sopori:  The Role of IL-1b in Nicotine-Induced Immunosuppression and Neuroimmune Communication.  J. Neuroimmune Pharmacol. 6(4): 585-96, 2011.

    2.        Singh, S. P, S. Gundavarapu, J. Pena-Philippides, J. Rir-sima-ah, N. C. Mishra, J. Wilder, V. Kurup and M. Sopori:  Gestational Secondhand Cigarette Smoke Promotes Th2 Immunity and Exacerbates Allergic Asthma.  J. Immunol. 187(9): 4542-52, 2011.

    3.        Langley, R. J., N. C. Mishra, J. C. Pena-Philippides, JC. Seagrave and M. L. Sopori:  Transcriptional Changes in Chronic Silicosis:  Activation of Fibrogenic, Chemokine and Oxidative Stress Genes in a Rat Model of Chronic Silicosis. J. Toxicol. Environ. Health A. 74(19): 1261-79, 2011.

    4.        Mishra, N. C., and M. L. Sopori: Chapter 23, Immunotoxicity. In: Veterinary Toxicology, Gupta R. C. (ed.). Oxford: Academic Press, pp 364-380, 2012.

    5.        Gundavarapu, S., J. Wilder, N. C. Mishra, J. Rir-sima-ah, R. Langley, R. Jaramillo, K. Gott, S. P. Singh, J. C. Pena-Philippides, K. S. Harrod, A. I. Saeed, J. M. McIntosh, S. Buch, M. Sopori. Critical role of nicotinic receptors in airway mucous cell function in vitro and in vivo. J. Allergy Clin. Immunol. (In Press).

    6.        Mishra, N. C., J. Rir-sima-ah, G. R. Grotendorst, R. J. Langley, S. P. Singh, S. Gundavarapu, W. M. Weber, J. C. Pena-Philippides, M. R. Duncan, and M. L. Sopori. Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: Possible role of Th17 cells in chronic lung pathology. Int. Immunopharmacol. 13: 101-108, 2012.

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