EDUCATION
B.S. (Chemistry and Biology) 1962, Kashmir University, India
M.S. (Biochemistry) 1964, Aligarh University, India
Ph.D. (Biochemistry) 1970, All India Institute of Medical Sciences, New Delhi,
     India

EMPLOYMENT

ADVISORY PANELS
Research Advisory Committee on Gulf War Veterans’ Illnesses, 2004, 2006
Current Issues in Smoking and HIV/AIDS,” 2007

STUDY SECTION MEMBER
Ad hoc Member, The National Institute for Drug Abuse Study Section, 1991, 1992, 1996
Member, Drugs of Abuse and AIDS Study Section, 1997-1998
Ad hoc Member, NIDA Special Emphasis Panel, 1998
Ad hoc Member, The National Center for Research Resources Comparative Medicine Review Group, 1998
Member, The National Institute of Drug Abuse Study Section, AARR5 (AIDS Neuropathogenesis and
     Morbidity Cofactors), 1998-2000
Reviewer, Ohio Cancer Research Associates, 1999
Ad hoc Member, National Institute for Environmental Health Sciences (NIEHS, Special Emphasis Panel),
     1999
Ad hoc Member, AARR6 (AIDS Neuropathogenesis and Morbidity Cofactors), 2000
Member, NIH Study Section: NeuroAIDS and Other Organ Diseases, 2000-July 2004
Member, Study Section for The California/Colorado Tobacco-Related Disease Research Program
     (General Biomedical Sciences Section), 2001-2004
Member, Philip Morris External Research Program, 2002-2005
Ad hoc Member, AIDS and Related Research Study Section (ZRG1 AARR16), March 2003
Ad hoc Member, NIH AIDS Clinical and Epi Studies (Special Emphasis Panel), July 2004
Ad hoc Member, NNB (Neuroendocrinology, Neuroimmunology, and Behavior) Study Section,
     November 2004
Ad hoc Member, NIH Study Section (NAED), March 2005
Ad hoc Member, NIH ZRG1 III (Innate Immunity and Inflammation), July 2005
Member, NIH Study Section on Biomedical and Behavioral Research Facilities (SRRB), September
     2005-Present
Member, NIH Study Section on Innate Immunity and Inflammation, November 2005-Present
Ad hoc Member, NIH Study Section on Neuroimmune Mechanisms and Chronic Fatigue Syndrome,
     January 2006
Ad hoc Member, NIH Study Section [NIAAA, Special Emphasis Panel (ZAA1 BB 91 1)], April 2007
Member, Study Section for The California/Colorado Tobacco-Related Disease Research Program
     (General Biomedical Sciences Section), 2007-Present

AREAS OF RESEARCH
Dr. Sopori's current research is directed to: (a) investigate the molecular mechanism of nicotine-induced immunosuppression, (b) explore the effects of nicotine on the inflammatory response in the lung and its possible role in the susceptibility to opportunistic infections, (c) examine the prospect of using nicotine to study the neuroimmune modulation, and (d) identify gene(s) which affect the sensitivity/resistance to ethanol-induced immunosuppression.

 

REPRESENTATIVE PUBLICATIONS

1. • Kalra, R., S. P. Singh, S. Razani-Borougerdi, R. J. Langley, W. B. Blackwell, R. F. Henderson and M. L. Sopori: Subclinical Doses of the Nerve Gas Sarin Impair T Cell Responses Through the Autonomic Nervous System. Toxicol. Appl. Pharmacol. 184(2): 82-87, 2002.

      

   • Sopori, M.: Effects of Cigarette Smoke on the Immune System. Nat. Rev. Immunol. 2: 372-377, 2002.

      

   • Singh, S. P., E. G. Barrett, R. Kalra, S. Razani-Boroujerdi, R. J. Langley, V. Kurup, Y. Tesfaigzi and M. L. Sopori: Prenatal Cigarette Smoke Decreases Lung cAMP and Increases Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med. 168(3): 342-347, 2003.

      

   • Benson, J., F. Hahn, T. March, J. McDonald, M. Sopori, J. Seagrave, A. Gomez, A. Bourdelais, J. Naar, J. Zaias, G. Bossart and D. Baden: Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for 5 Days. J. Toxicol. Environ. Health A 67(18): 1443-1456, 2004.

      

   • Kalra, R., S. P. Singh, J. C. Pena-Philippides, R. J. Langley, S. Razani-Boroujerdi and M. L. Sopori: Immunosuppressive and Anti-inflammatory Effects of Nicotine Administered by Patch in an Animal Model. Clin. Diagn. Lab. Immunol. 11(3): 563-568, 2004.

      

   • Langley, R. J., R. Kalra, N. C. Mishra, F. F. Hahn, S. Razani-Boroujerdi, S. P. Singh, J. M. Benson, J. C. Pena-Philippides, E. B. Barr and M. L. Sopori: A Biphasic Response to Silica. I. Immunostimulation is Restricted to the Early Stage of Silicosis in Lewis Rats. Am. J. Respir. Cell Mol. Biol. 30: 823-829, 2004.

      

   • Langley, R. J., R. Kalra, N. C. Mishra and M. L. Sopori: Central But Not the Peripheral Action of Cholinergic Compounds Suppresses the Immune System. J. Neuroimmunol. 148: 140-145, 2004.

      

   • Razani-Boroujerdi, S., S. P. Singh, C. Knall, F. F. Hahn, J. C. Pena-Philippides, R. Kalra, R. J. Langley and M. L. Sopori: Chronic Nicotine Inhibits Inflammation and Promotes Influenza Infection. Cell. Immunol. 230(1): 1-9, 2004.

      

   • Benson, J. M., F. F. Hahn, T. H. March, J. D. McDonald, A. P. Gomez, M. L. Sopori, A. J. Bourdelais, J. Naar, J. Zaias, G. D. Bossart and D. G. Baden: Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for Twenty-two Days. Environ. Health Perspect. 113: 626-631, 2005.

      

   • Sopori, M. L., S. Razani-Boroujerdi and S. P. Singh: Chapter 8, Immunomodulatory Effects of Cigarette Smoke/Nicotine. In Infectious Diseases and Substance Abuse (H. Friedman, T. W. Klein and M. Bendinelli, eds.), pp. 103-110, Kuwer Academic/Plenum Publishers, New York, 2005.

      

   • Singh, S. P., S. Razani-Boroujerdi, J. C. Pena-Philippides, R. J. Langley, N. C. Mishra and M. L. Sopori: Early Postnatal Exposure to Cigarette Smoke Impairs the Antigen-Specific T-Cell Responses in the Spleen. Toxicol. Lett. 167(3): 231-237, 2006.

      

   • Pena-Philippides, J. C., S. Razani-Boroujerdi, S. P. Singh, R. J. Langley, N. C. Mishra, R. F. Henderson and M. L. Sopori: Long- and Short-Term Changes in the Neuroimmune-Endocrine Parameters Following Inhalation Exposures of F344 Rats to Low-Dose Sarin. Toxicol. Sci. 97(1): 181-188, 2007.

      

   • Razani-Boroujerdi, S., R. T. Boyd, M. I. Davila-Garcia, J. S. Nandi, N. C. Mishra, S. P. Singh, J. C. Philippides, R. Langley and M. L. Sopori: T Cells Express a7-Nicotinic Acetylcholine Receptor Subunits that Require a Functional TCR and Leukocyte-Specific Tyrosine Kinase for Nicotine-Induced Ca²⁺ Response. J. Immunol. 179(5): 2889-2898, 2007.

      

   • Razani-Boroujerdi, S. and M. L. Sopori: Early Manifestations of NNK-Induced Lung Cancer: Role of Lung Immunity in Tumor Susceptibility. Am. J. Respir. Cell Mol. Biol. 36(1): 13-19, 2007.

      

   • Mishra, N. C., J. Rir-Sima-ah, R. J. Langley, S. P. Singh, J. C. Peña-Philippides, T. Koga, S. Razani-Boroujerdi, J. Hutt, M. Campen, K. C. Kim, Y. Tesfaigzi and M. L. Sopori: Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens. J. Immunol. 180(11): 7655-7663, 2008.

      

   • Razani-Boroujerdi, S., M. Behl, F. F. Hahn, J. C. Pena-Philippides, J. Hutt and M. L. Sopori: Role of Muscarinic Receptors in the Regulation of Immune and Inflammatory Responses. J. Neuroimmunol. 194(1-2): 83-88, 2008.

      

   • Zhuang, J., F. Xu, M. J. Campen, C. Zhang, J. C. Pena-Philippides and M. L. Sopori: Inhalation of the Nerve Gas Sarin Impairs Ventilatory Responses to Hypercapnia and Hypoxia in Rats. Toxicol. Appl. Pharmacol. 232(3): 440-447, 2008.

      

   • Singh, S. P., N. C. Mishra, J. Rir-sima-ah, M. Campen, V. Kurup, S. Razani-Boroujerdi and M. L. Sopori: Maternal Exposure to Secondhand Cigarette Smoke Primes the Lung for Induction of Phosphodiesterase4D5 Isozyme and Exacerbated Th2 Responses; Rolipram Attenuates the Airway Hyperreactivity and Muscarinic Receptor Expression but not Lung Inflammation and Atopy. J. Immunol. 183(3): 2115-2121, 2009.