EDUCATION
B.S. (Biology) 1996, Texas Christian University
Ph.D. (Biomedical Sciences; emphasis in Microbiology and Immunology) 2001,
     University of North Texas Health Sciences Center

EMPLOYMENT

PROFESSIONAL AFFILIATION
American Society for Microbiology

PROFESSIONAL SERVICE
Ad-Hoc reviewer for Veterinary Microbiology, 2002-Present
Ad-Hoc reviewer for Small Ruminant Research, 2003-2004
Ad-Hoc reviewer for the Journal of Antimicrobial Chemotherapy, 2004
ASM Minority Mentor, 2005-Present
ASM International Mentor, 2006-Present
Abstract reviewer for the Sitlington Infectious Diseases Symposium on Bioterrorism
     and Emerging Infectious Diseases, Stillwater, OK, April 21, 2005
Abstract reviewer for the Sitlington Infectious Diseases Symposium on Antimicrobial
     Drug Resistance, Stillwater, OK, April 24, 2006

AREAS OF RESEARCH
Select agent and emerging infectious disease pathogenesis, with emphasis on molecular characterization of disease (virulence factors and determinants). Antibacterial drug development and testing (in vitro and in vivo). Understanding intrinsic and acquired antibacterial drug resistance, with particular regard to overcoming such resistances.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

 

REPRESENTATIVE PUBLICATIONS

1. Valderas, M. W. and M. E. Hart: Identification and Characterization of a Second Superoxide Dismutase Gene (sodM) from Staphylococcus aureus. J. Bacteriol. 183(11): 3399-3407, 2001.

    

2. Valderas, M. W., J. W. Gatson, N. Wreyford and M. E. Hart: The Superoxide Dismutase Gene, sodM is Unique to Staphylococcus aureus: Absence of sodM in the Coagulase Negative Staphylococci. J. Bacteriol. 184(9): 2465-2472, 2002.

    

3. Alcantara, R. B., R. D. A. Read, M. W. Valderas, T. D. Brown and R. M. Roop II: Intact Purine and Branched-Chain Amino Acid Biosynthesis Pathways are Required for the Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model. Infect. Immun. 72(8): 4911-4917, 2004.

    

4. Roop, R. M., II, B. H. Bellaire, M. W. Valderas and J. A. Cardelli: Adaptation of the Brucellae to Their Divergent Intracellular Niches. Mol. Microbiol. 52(3): 621-630, 2004.

    

5. Gee, J. M., M. W. Valderas, M. E. Kovach, V. K. Grippe, G. T. Robertson, W. Ng, J. M. Richardson, M. E. Winkler and R. M. Roop II: The Brucella abortus Cu/Zn Superoxide Dismutase (SodC) is Required for Optimal Resistance to Oxidative Killing by Murine Macrophages and Wild Type Virulence in Experimentally Infected Mice. Infect. Immun. 73(5): 2873-2880, 2005.

    

6. Valderas, M. W., R. B. Alcantara, J. E. Baumgartner, B. H. Bellaire, G. T. Robertson, W. Ng, J. M. Richardson, M. E. Winkler and R. M. Roop II: Role of HdeA in Acid Resistance and Virulence in Brucella abortus 2308. Vet. Microbiol. 107: 307-312, 2005.

    

7. Barrow, E. W., T. R. Colberg, M. W. Valderas, P. C. Bourne and W. W. Barrow: Development of Colorimetric Drug Screening Assay for Bacillus anthracis. Int. J. Antimicrob. Agents 27: 178-180, 2006.

    

8. Valderas, M. W. and R. M. Roop II: Brucella and Bioterrorism. In Microorganisms and Bioterrorism (B. Anderson, H. Friedman and M. Bendinelli, eds.), pp. 139-153, Springer, New York, NY, 2006.

    

9. Valderas, M. W., P. C. Bourne and W. W. Barrow: Genetic Basis for Sulfonamide Resistance in Bacillus anthracis. Microb. Drug Resist. 13(1): 12-21, 2007.

    

10. Valderas, M. W. and W. W. Barrow: Establishment of a Method for Evaluating Intracellular Antibiotic Efficacy in Brucella abortus-Infected Mono Mac 6 Monocytes. J. Antimicrob. Chemother. 61(1): 128-134, 2008.

     

11. Valderas, M. W., B. Andi, W. W. Barrow and P. F. Cook: Examination of Intrinsic Sulfonamide Resistance in Bacillus anthracis: A Novel Assay for Dihydropteroate Synthase. Biochim. Biophys. Acta 1780(5): 848-853, 2008.

     

12. Anderson, E. S., J. T. Paulley, J. M. Gaines, M. W. Valderas, D. W. Martin, E. Menscher, T. D. Brown, C. S. Burns and R. M. Roop, II: The Manganese Transporter MntH is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice. Infect. Immun. 77(8): 3466-3474, 2009.