EDUCATION
B.S. (Science and Mathematics in Chemistry) 2002, University of South Carolina
M.S. (Environmental Sciences and Engineering) 2003, University of North
Carolina at Chapel Hill
Ph.D. (Environmental Sciences and Engineering) 2006, University of North
Carolina at Chapel Hill
EMPLOYMENT
|
2/07 - Present |
Associate Research Scientist, Chemistry and Inhalation Exposure Program/Inhalation Toxicology, Lovelace Respiratory Research Institute, Albuquerque, NM |
|
6/03 - 2/07 |
Research Assistant, Atmospheric Chemistry and Environmental Toxicology, Department of Environmental Sciences and Engineering, The University of North Carolina-Chapel Hill, Chapel Hill, NC |
|
8/99 - 5/02 |
Research Assistant, Geological Sciences, Department of Geological Sciences, University of South Carolina, Columbia, SC |
HONORS AND AWARDS
Delta Omega
Phi Beta Kappa
SOT Inhalation Specialty Section Mary O. Amdur Student Award
SOT Graduate Student Travel Award
International Society of Exposure Assessment Student Award
Golden Key Honor Society
PROFESSIONAL AFFILIATIONS
Society of Toxicology
North Carolina Society of Toxicology
Mountain West Society of Toxicology
International Society Exposure Analysis
American Association of Aerosol Research
AREAS OF RESEARCH
Dr. Doyle-Eisele is involved in various GLP and non-GLP pharmaceutical pre-clinical toxicological studies at LRRI that evaluate the acute toxicity, deposition, pharmacokinetics, and efficacy utilizing a variety of respiratory disease models. Respiratory disease models evaluated include LPS COPD model and bleomycin sulfate IPF model. Additional research includes pharmacokinetics and ADME studies evaluating various chemicals/pharmaceuticals (radiolabeled and non-labeled). Dr. Doyle-Eisele’s other efforts have utilized her experience prior to LRRI with environmental chambers and toxicology to develop, characterize, and operate the Lovelace indoor environmental chamber to examine the toxicity of biogenic and industrial air pollutants.
REPRESENTATIVE PUBLICATIONS
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Doyle, M., K. G. Sexton, H. Jeffries, K. Bridge and I. Jaspers: Effects of 1,3-Butadiene, Isoprene, and Their Photochemical Degradation Products on Human Lung Cells. Environ. Health Perspect. 112(15): 1488-1495, 2004.
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Sexton, K. G., H. E. Jeffries, M. Jang, R. M. Kamens, M. Doyle, I. Voicu and I. Jaspers: Photochemical Products in Urban Mixtures Enhance Inflammatory Responses in Lung Cells. Inhal. Toxicol. 16(Suppl. 1): 107-114, 2004.
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Doyle, M., K. G. Sexton, H. Jeffries and I. Jaspers: Atmospheric Photochemical Transformations Enhance 1,3-Butadiene-Induced Inflammatory Responses in Human Epithelial Cells: The Role of Ozone and Other Photochemical Degradation Products. Chem. Biol. Interact. 166(1-3): 163-169, 2007.
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Sexton, K. G., M. L. Doyle, H. E. Jeffries and S. Ebersviller: Development and Testing of a Chemical Mechanism for Atmospheric Photochemical Transformations of 1,3-Butadiene. Chem. Biol. Interact. 166(1-3): 156-162, 2007.
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de Bruijne, K., S. Ebersviller, K. G. Sexton, S. Lake, D. Leith, R. Goodman, J. Jetters, G. W. Walters, M. Doyle-Eisele, R. Woodside, H. E. Jeffries and I. Jaspers: Design and Testing of Electrostatic Aerosol In VitroExposure System (EAVES): An Alternative Exposure System for Particles. Inhal. Toxicol. 21(2): 91-101, 2009.
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Vodak, D. T., D. E. Dobry, P. J. Kuehl, M. Doyle-Eisele, J. D. McDonald, A. Silcock, G. Magee, D. Pole, W. K. Miller, D. Friesen and D. K. Lyon: Platform Formulation Development Utilizing a Novel Pulmonary Excipient and In Vivo Evaluation of Engineered Particles of Fluticasone Propionate as a Model Formulation. In Proceedings of Respiratory Drug Delivery 2009, Vol. 2, pp. 251-254 (in review).