EDUCATION
B.S. (Biochemistry) 1963, Louisiana State University
M.D. (Medicine) 1967, Louisiana State University, School of Medicine

PROFESSIONAL CERTIFICATION
Licensed Physician and Surgeon, State of Louisiana, 1967-1977
Diplomate, American Board of Pathology (Anatomic and Clinical), 1972
Licensed Physician, State of Texas, #E6836, 1976-1994
Special Qualification in Pathology/Immunopathology, American Board of
     Pathology, 1983
Licensed Physician, State of New Mexico, #94-303, 1994-Present

EMPLOYMENT

PROFESSIONAL AFFILIATIONS
Association of American Medical Colleges (AAMC)
American Society of Clinical Pathologists (ASCP), 1976-Present
American Association of Immunologists (AII), 1978-Present
American Thoracic Society (ATS), 1982-Present
Member, Pathology A Study Section, NIH, 1987-1991
American Association for the Advancement of Science (AAAS), 1989-Present
Member, Microbiology and Infectious Disease Committee, NIH, NIAID,
     1993-1997
New Mexico Society of Pathology, 1994-Present
Universities Associated for Research and Education in Pathology (UAREP),
     1994-Present
Fellow, College of American Pathologists (CAP), 1994-Present
American Society of Investigative Pathology (ASIP) Council, 1995-Present
Association of Pathology Chairs (APC), 1995-Present
Member, Advisory Council, NHLBI, 2000-2003
Greater Albuquerque Medical Association (GAMA), 2001-Present 

AREAS OF RESEARCH
Dr. Lipscomb's research laboratory investigates mechanisms of immune regulation in the lung using both infectious and allergic pulmonary inflammation models. For infection models, pathogens are deposited via the nasal or intratracheal routes and clearance is followed over time. In the past, Dr. Lipscomb focused on Cryptococcus neorformans, an encapsulated yeast, to study the mechanisms of T cell mediated immunity, and effector mechanisms needed for clearance that include macrophage activation and the production of NO. Currently, she is focusing on organisms that are used as bioweapons, particularly Bacillus anthracis. Working with Dr. Rick Lyons and members of his research team, who have characterized the early stages of a pulmonary anthrax infection, Dr. Lipscomb's lab will continue to identify the stages of development of immunity, effector mechanisms when successful clearance of the organism occurs, and the best method to effectively protect a naive host against an aerosol exposure to the spores. The models used to study the pulmonary allergic inflammation that mimics human asthma uses both standard mouse inbred strains and transgenics such as the OVA peptide T cell receptor transgenic mice (DO11.10 mice) or adoptive transfer of cells from these transgenic mice. Dr. Lipscomb is particularly interested in the role lung dendritic cells play in the initiation and exacerbations of allergic pulmonary inflammation. Finally, she is also studying human lung tissue and alveolar cells and fluids to determine the role human lung dendritic cells might play in maintaining chronic inflammation in human asthma.

REPRESENTATIVE PUBLICATIONS

1. Kepley, C. L., P. J. McFeeley, J. M. Oliver and M. F. Lipscomb: Immunohistochemical Detection of Human Basophils in Postmortem Cases of Fatal Asthma.Am. J. Respir. Crit. Care Med. 164: 1053-1058, 2001.

    

2. MacPherson, J. C., S. A. Comhair, S. C. Erzurum, D. F. Klein, M. F. Lipscomb, M. S. Kavuru, M. K. Samoszuk and S. L. Hazen: Eosinophils are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species.J. Immunol. 166: 5763-5772, 2001.

    

3. Wilder, J. A., D. D. Collie, D. E. Bice, Y. Tesfaigzi, C. R. Lyons and M. F. Lipscomb: Ovalbumin Aerosols Induce Airway Hyperreactivity in Naïve DO11.10 T Cell Receptor Transgenic Mice Without Pulmonary Eosinophilia or OVA-Specific Antibody. J. Leukoc. Biol. 69: 538-547, 2001.

    

4. Masten, B. J. and M. F. Lipscomb: Dendritic Cells: Immune Regulators in Health and Disease. Physiol. Rev. 82(1): 97-130, 2002.

    

5. Wilder, J. A., G. K. Olson, Y. C. Chang, K. J. Kwon-Chung and M. F. Lipscomb: Complementation of a Capsule Deficient Cryptococcus neoformans withCAP64 Restores Virulence in a Murine Lung Infection. Am. J. Respir. Cell Mol. Biol. 26: 306-314, 2002.

    

6. Masten, B., B. McWilliams, M. Lipscomb, T. Archibeque, C. Qualls, H. W. Kelly, M. Schuyler: Immune Response to Hepatitis B Vaccine in Asthmatic Children.Pediatr. Pulmonol. 36: 522-528, 2003.

    

7. Masten, B. J., G. K. Olson, D. F. Kusewitt and M. F. Lipscomb: Flt3 Ligand Preferentially Increases the Number of Functionally Active Myeloid Dendritic Cells in the Lungs of Mice. J. Immunol. 172: 4077-4083, 2004.

    

8. Lyons, C. R., J. Lovchik, J. Hutt, M. F. Lipscomb, E. Wang, S. Heninger, L. Berliba and K. Garrison: Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology and Mouse Strain Susceptibility. Infect. Immun. 72: 4801-4809, 2004.

    

9. Heninger, S., M. Drysdale, J. Lovchik, J. Hutt, M. F. Lipscomb, T. M. Koehler and C. R. Lyons: Toxin-Deficient Mutants of Bacillus anthracis are Lethal in a Murine Model for Pulmonary Anthrax. Infect. Immun. 74(11): 6067-6074, 2006.

    

10. Masten, B. J., G. K. Olson, C. A. Tarleton, C. Rund, M. Schuyler, R. Mehran, T. Archibeque and M. F. Lipscomb: Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung. J. Immunol. 177(11): 7784-7793, 2006.

     

11. Lipscomb, M. F., J. A. Wilder and B. J. Masten: Dendritic Cell Ontogeny and Biology. In Dendritic Cells in the Pathogenesis and Immunity of HIV Infection(S. Gessani and F. Belardelli, eds.), Springer Publishers (in press).