BRUSE, KRISTY D., PHD

 EDUCATION
 B.S. (Biology) 1982, University of Missouri-Kansas City, Kansas City, MO
 M.S. (Biology) 1986, Southwest Missouri State University, Springfield, MO
 Ph.D. (Pharmacology and Toxicology) 1996, Medical College of Virginia-VCU, Richmond, VA 

 


 EMPLOYMENT

11/09 - Present Director, Cardiopulmonary Safety Pharmacology, Lovelace Respiratory Research Institute, Albuquerque, NM
6/08 - Present Safety Pharmacologist Independent Consultant, Associate Consultant with Paracelsus, Inc.
10/06 - 6/08 Study Director, Safety Pharmacology, Covance Laboratories, Inc., Madison, WI
2/04 - 10/06 Research Leader, Safety Pharmacology, Hoffmann-La Roche Inc., Nutley, NJ
9/01 - 1/04 Staff Pharmacologist, Department of Safety Pharmacology, WIL Research Laboratories, Inc., Ashland, OH
1/97 - 9/01 Postdoctoral Fellow, University of Iowa, Iowa City, IA
9/94 - 12/96 Veterinary Assistant, Veterinary Emergency Clinic, Richmond, VA
8/93 - 12/96 Graduate Student, VCU-Medical College of VA, Richmond, VA
4/92 - 8/93 Senior Research Associate, Scios Nova, Inc., Mountain View, CA
8/88 - 4/92 Biologist I/II, Syntex, Palo Alto, CA
5/88 - 12/89 Veterinary Assistant, Alameda County Emergency Animal Hospital, San Leandro, CA
7/87 - 8/88 Veterinary Assistant/Oncology, Berkeley Dog and Cat Hospital, Berkeley, CA
4/87 - 7/87 Veterinary Assistant, Sunset Animal Clinic, Suisun City, CA
1/87 - 7/87 Staff Research Associate, University of CA-Davis, Davis, CA
9/82 - 4/83 Veterinary Assistant/Office Manager, Stanley Veterinary Clinic, Stanley, KS
8/82 - 5/86 Graduate Student, Southwest Missouri State University, Springfield, MO
5/82 - 9/82 Research Assistant, Home Office Reference Laboratories, Shawnee Mission, KS
9/81 - 4/83 Veterinary Assistant, Emergency Veterinary Clinic, Overland Park, KS
10/77 - 9/81 Research Assistant I/II/Lab Manager, University of Kansas Medical Center, Kansas City, KS


 
 

PROFESSIONAL AFFILIATIONS
 Safety Pharmacology Society 

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
 
 
 

REPRESENTATIVE PUBLICATIONS
 (Also published under the names K. Lake and K. Lake-Bruse.)

  1. Savin, V. J., R. V. Patak, G. Marr, A. S. Hermreck, S. M. Ridge and K. Lake: Glomerular Ultrafiltration Coefficient After Ischemic Renal Injury in Dogs. Circ. Res. 53(4): 439-447, 1983.

     

  2. Sharif, N. A., J. L. Nunes, K. D. Lake, D. L. McClelland, S. F. Corkins, I. Lakatos, R. P. Rosenkranz, R. L. Whiting and R. M. Eglen: Chronic Manipulation of Dietary Salt Modulates Renal Physiology and Kidney Dopamine Receptor Subtypes: Functional and Autoradiographic Studies. Gen. Pharmacol. 26(4): 727-735, 1995.

     

  3. Varga, K., K. Lake, B. R. Martin and G. Kunos: Novel Antagonist Implicates the CB1 Cannabinoid Receptor in the Hypotensive Action of Anandamide. Eur. J. Pharmacol. 278(3): 279-283, 1995.

     

  4. Ishac, E. J., L. Jiang, K. D. Lake, K. Varga, M. E. Abood and G. Kunos: Inhibition of Exocytotic Noradrenaline Release by Presynaptic Cannabinoid CB1 Receptors on Peripheral Sympathetic Nerves. Br. J. Pharmacol. 118(8): 2023-2028, 1996.

     

  5. Varga, K., K. D. Lake, D. Huangfu, P. G. Guyenet and G. Kunos: Mechanism of the Hypotensive Action of Anandamide in Anesthetized Rats. Hypertension 28(4): 682-686, 1996.

     

  6. Lake, K. D., D. R. Compton, K. Varga, B. R. Martin and G. Kunos: Cannabinoid-Induced Hypotension and Bradycardia in Rats is Mediated by CB1-Like Cannabinoid Receptors. J. Pharmacol. Exp. Ther. 281(3): 1030-1037, 1997.

     

  7. Lake, K. D., B. R. Martin, G. Kunos and K. Varga: Cardiovascular Effects of Anandamide in Anesthetized and Conscious Normotensive and Hypertensive Rats. Hypertension 29(5): 1204-1210, 1997.

     

  8. Christenson, S. D., K. D. Lake, H. Ooboshi, F. M. Faraci, B. L. Davidson and D. D. Heistad: Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue in Mice. Stroke 29(7): 1411-1416, 1998.

     

  9. Járai, Z., J. A. Wagner, K. Varga, K. D. Lake, D. R. Compton, B. R. Martin, A. M. Zimmer, T. I. Bonner, N. E. Buckley, E. Mezey, R. K. Razdan, A. Zimmer and G. Kunos: Cannabinoid-Induced Mesenteric Vasodilatation Through an Endothelial Site Distinct from CB1 and CB2 Receptors. Proc. Natl. Acad. Sci. USA 96(4): 14136-14141, 1999.

     

  10. Lake-Bruse, K. D., F. M. Faraci, E. G. Shesely, N. Maeda, C. D. Sigmund and D. D. Heistad: Gene Transfer of Endothelial Nitric Oxide Synthase (eNOS) in eNOS-Deficient Mice. Am. J. Physiol. 277(2 Pt. 2): H770-H776, 1999.

     

  11. Lake-Bruse, K. D. and C. D. Sigmund: Transgenic and Knockout Mice to Study the Renin-Angiotensin System and Other Interacting Vasoactive Pathways. Curr. Hypertens. Rep. 2(2): 211-216, 2000.

     

  12. Lavoie, J. L., K. D. Lake-Bruse and C. D. Sigmund: Increased Blood Pressure in Transgenic Mice Expressing Both Human Renin and Angiotensinogen in the Renal Proximal Tubule. Am. J. Physiol. Renal Physiol. 286(5): F965-F971, 2004.

     

  13. Guo, L., Z. Dong, H. Guthrie and K. Bruse: Detection of Cardiovascular Liabilities of Potential Drug Candidates Using the Isolated Guinea Pig Langendorff Heart Assay. J. Pharmacol. Toxicol. Methods 56(2): e9, Fourth Annual Focus on Safety Pharmacology, 2007.

     

  14. Bass, A. S., B. Darpo, A. Breidenbach, K. Bruse, H. S. Feldman, D. Garnes, T. Hammond, W. Haverkamp, C. January, J. Koerner, C. Lawrence, D. Leishman, D. Roden, J. P. Valentin, M. A. Vos, Y.-Y. Zhou, T. Karluss and P. Sager: International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) Initiative on Moving Towards Better Predictors of Drug-Induced Torsades de Pointes. Br. J. Pharmacol. 154(7): 1491-1501, 2008.

     

  15. Lindgren, S., A. S. Bass, R. Briscoe, K. Bruse, G. S. Friedrichs, M. J. Kallman, C. Markgraf, L. Patmore and M. R. Pugsley: Benchmarking Safety Pharmacology Regulatory Packages and Best Practice. J. Pharmacol. Toxicol. Methods 58(2): 99-109, 2008.
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