SMITH, KEVIN R., PHD

EDUCATION
B.S. (Chemistry) 1992, Weber State University
Ph.D. (Biochemistry) 2000, Utah State University
Postdoctoral Fellow (Inhalation Toxicology) 1999-2004, University of California-Davis

EMPLOYMENT

10/08 - Present Associate Research Scientist, COPD Program, Lovelace Respiratory Research Institute, Albuquerque, NM
5/06 - 9/08 Senior Scientist, Schering-Plough Research Institute, Schering-Plough Corporation
3/04 - 4/06 Assistant Project Scientist, Center for Health and the Environment, University of California-Davis
11/99 - 2/04 Post Graduate Researcher (Postdoctoral Fellow), Center for Health and the Environment, University of California-Davis
12/94 - 11/99 Research Assistant, Department of Chemistry and Biochemistry, Utah State University
9/93 - 12/94 Teaching Assistant, Department of Chemistry and Biochemistry, Utah State University
5/92 - 8/93 Associate Scientist, TheraTech, Inc. (acquired by Watson Pharmaceuticals, Inc.)
10/89 - 5/92 Analytical Chemist, Monarch Nutritional Laboratories


PROFESSIONAL AFFILIATIONS
American Thoracic Society
Society of Toxicology

PATENT
Hammock, B. D., K. E. Pinkerton, K. R. Smith, T. Watanabe, S. J. Ma and The Regents of the University of California: Use of Cis-Epoxyeicosatrienoic Acids and Inhibitors of Soluble Epoxide Hydrolase to Reduce Pulmonary Infiltration by Neutrophils. U.S. Patent Application 20050222252 A1 (October 6, 2005) and International Publication Number WO 2005/094373 A2 (October 13, 2005).



AREAS OF RESEARCH
Dr. Smith is interested in investigating the roles of inflammatory and apoptotic pathways involved in the development and progression of emphysema and chronic bronchitis. He also employs histological and morphometric techniques for assessment of lung pathology to investigate potential therapeutics for various lung disorders.

 

REPRESENTATIVE PUBLICATIONS

  1. Aust, A. E., K. R. Smith and J. C. Ball: Iron in Airborne Particulates May be Important in Lung Damage. In Particulate Matter: Health and Regulatory Issues, pp. 169-176, Air & Waste Management Association, Pittsburgh, PA, 1995.

     

  2. Smith, K. R. and A. E. Aust: Mobilization of Iron from Urban Particulates Leads to Generation of Reactive Oxygen Species In Vitro and Induction of Ferritin Synthesis in Human Lung Epithelial Cells. Chem. Res. Toxicol. 10: 828-834, 1997.

     

  3. Smith, K. R., J. M. Veranth, J. S. Lighty and A. E. Aust: Mobilization of Iron from Coal Fly Ash was Dependent Upon the Particle Size and the Source of Coal. Chem. Res. Toxicol. 11: 1494-1500, 1998.

     

  4. van Maanen, J. M. S., P. J. A. Borm, A. Knaapen, M. van Herwijnen, P. A. E. L. Schilderman, K. R. Smith, A. E. Aust, M. Tomatis and B. Fubini: In Vitro Effects of Coal Fly Ashes: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells. Inhal. Toxicol. 11: 1123-1141, 1999.

     

  5. Ball, B. R., K. R. Smith, J. M. Veranth and A. E. Aust: Bioavailability of Iron from Coal Fly Ash: Mechanisms of Mobilization and of Biological Effects. Inhal. Toxicol. 12: S209-S225, 2000.

     

  6. Smith, K. R., J. M. Veranth, A. A. Hu, J. S. Lighty and A. E. Aust: Interleukin-8 Levels in Human Lung Epithelial Cells are Increased in Response to Coal Fly Ash and Vary with the Bioavailability of Iron, as a Function of Particle Size and Source of Coal. Chem. Res. Toxicol. 13: 118-125, 2000.

     

  7. Veranth, J. M., K. R. Smith, A. E. Aust, S. L. Dansie, J. B. Griffin, A. A. Hu, M L. Huggins and J. S. Lighty: Coal Fly Ash and Mineral Dust for Toxicology and Particle Characterization Studies: Equipment and Methods for PM2.5- and PM1-Enriched Samples. Aerosol Sci. Technol. 32: 127-141, 2000.

     

  8. Veranth, J. M., K. R. Smith, A. A. Hu, J. S. Lighty and A. E. Aust: Mobilization of Iron from Coal Fly Ash was Dependent Upon the Particle Size and Source of Coal: Analysis of Rates and Mechanisms. Chem. Res. Toxicol. 13: 382-389, 2000.

     

  9. Veranth, J. M., K. R. Smith, F. Huggins, A. A. Hu, J. S. Lighty and A. E. Aust: Mössbauer Spectroscopy Indicates that Iron in an Aluminosilicate Glass Phase is the Source of the Bioavailable Iron from Coal Fly Ash. Chem. Res. Toxicol. 13: 161-164, 2000.

     

  10. Aust, A. E., J. C. Ball, A. A. Hu, J. S. Lighty, K. R. Smith, A. M. Straccia, J. M. Veranth and W. C. Young: Particle Characteristics Responsible for Effects on Human Lung Epithelial Cells. Res. Rep. Health Eff. Inst. (110): 1-76, 2002.

     

  11. Smith, K. R., D. L. Uyeminami, U. P. Kodavanti, J. D. Crapo, L.-Y. Chang and K. E. Pinkerton: Inhibition of Tobacco Smoke-Induced Lung Inflammation by a Catalytic Antioxidant. Free Radic. Biol. Med. 33: 1106-1114, 2002.

     

  12. Smith, K. R., S. Kim, J. J. Recendez, S. V. Teague, M. G. Ménache, D. E. Grubbs, C. Sioutas and K. E. Pinkerton: Airborne Particles of the California Central Valley Alter the Lungs of Healthy Adult Rats. Environ. Health Perspect. 111: 902-908, 2003.

     

  13. Smith, K. R., K. E. Pinkerton, T. Watanabe, T. L. Pedersen, S. J. Ma and B. D. Hammock: Attenuation of Tobacco Smoke-Induced Lung Inflammation by Treatment with a Soluble Epoxide Hydrolase Inhibitor. Proc. Natl. Acad. Sci. USA 102: 2186-2191, 2005.

     

  14. Smith, K. R., J. M. Veranth, U. P. Kodavanti, A. E. Aust and K. E. Pinkerton: Acute Pulmonary and Systemic Effects of Inhaled Coal Fly Ash in Rats: Comparison to Ambient Environmental Particles. Toxicol. Sci. 93: 390-399, 2006.

     

  15. Pinkerton, K. E., Y. Zhou, C. Zhong, K. R. Smith, S. V. Teague, I. M. Kennedy and M. G. Ménache: Mechanisms of Particulate Matter Toxicity in Neonatal and Young Adult Rat Lungs. Res. Rep. Health Eff. Inst. (135): 2008.
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