EDUCATION
M.D. (Medicine) 1983, Xuzhou Medical College, People's Republic of China
Ph.D. (Physiology) 2000, Shanghai Institute of Physiology, Chinese Academy of
     Sciences, China

EMPLOYMENT

PROFESSIONAL AFFILIATIONS
American Thoracic Society
The American Physiological Society
Society for Neuroscience

AREAS OF RESEARCH
Dr. Zhuang’s current studies focus on: (1) the interactions between inputs from the peripheral or central chemoreceptors and the pulmonary nonmyelinated fibers in the control of breathing; (2) the roles of neurogenic factors in bronchopulmonary inflammation and chronic obstructive pulmonary disease as well as their effects on breathing control; and (3) the electrophysiological properties and the related signal transduction of chemosensitive and respiratory-related neurons involved in the regulation of respiration under physiological and pathophysiological conditions. His previous studies had focused on the cardiovascular, respiratory adaptation to environmental factors, e.g., high altitude or hypoxia; population variation in adaptation to hypoxia and susceptibility to chronic mountain sickness; ischemic/hypoxic preconditioning of myocardium.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

 

REPRESENTATIVE PUBLICATIONS

1. Curran, L. S., J. G. Zhuang, T. S. Droma, L. Land and L. G. Moore: Hypoxic Ventilatory Responses in Tibetan Residents of 4400 m Compared with 3658 m. Respir. Physiol. 100: 223-230, 1995.

    

2. Niermeyer, S., P. Yang, Shanmina, Drolkar, J. Zhuang and L. G. Moore: Arterial Oxygen Saturation in Tibetan and Han Infants Born in Lhasa, Tibet. New Eng. J. Med. 333(19): 1248-1252, 1995.

    

3. Sun, S. F., C. Oliver-Pickett, P. Yang, A. J. Micco, T. S. Droma, S. Zamudio, J. G. Zhuang, S. Y. Huang, R. G. McCullough, A. Cymerman and L. G. Moore: Breathing and Brain Blood Flow During Sleep in Patients with Chronic Mountain Sickness. J. Appl. Physiol. 81(2): 611-618, 1996.

    

4. Zhou, Z. N., X. F. Wu, L. Q. He and J. G. Zhuang: Experimental Study of Increased Arterial Oxygen Saturation Using Health Exerciser Under Hypoxia. Hypoxia Medical J. 4(4): 20-22, 1996.

    

5. Zhuang, J. G., T. S. Droma, J. R. Sutton, B. M. Groves, R. E. McCullough, R. G. McCullough, S. F. Sun and L. G. Moore: Smaller Alveolar-Arterial O₂ Gradients in Tibetan than Han Residents of Lhasa (3658m). Respir. Physiol. 103(1): 75-82, 1996.

    

6. Curran, L. S., J. G. Zhuang, S. F. Sun and L. G. Moore: Ventilation and Hypoxic Ventilatory Responsiveness in Chinese-Tibetan Residents at 3,658m. J. Appl. Physiol. 83(6): 2098-2104, 1997.

    

7. Dai, J., J. G. Zhuang, Z. N. Zhou, Y. H. Lu and Y. R. Huang: Changes of HEP, pH_i in Isolated Rat Hearts Under Hypoxic Perfusion and Reoxygenation – A ³¹P NMR Study. Chin. J. Physiol. Sci. 13(1): 87-91, 1997.

    

8. Lu, Z., J. G. Zhuang, Y. H. Lu, C. L. Wu, Z. N. Zhou and Y. R. Huang: Isolated Perfusion Model for NMR Measurement. Physiologica Sinica (in Chinese) 49(2): 230-234, 1997.

    

9. Curran, L. S., J. G. Zhuang, T. S. Droma and L. G. Moore: Superior Exercise Performance in Lifelong Tibetan Residents of 4,400m Compared with Tibetan Residents of 3,658m. Am. J. Phys. Anthropol. 105: 21-30, 1998.

    

10. Halperin, B. D., S. Sun, J. Zhuang, T. Droma and L. G. Moore: ECG Observations in Tibetan and Han Residents of Lhasa. J. Electrocardiol. 31(3): 237-243, 1998.

     

11. Zhuang, J. G. and Z. N. Zhou: Protective Effects of Intermittent Hypoxic Adaptation on Myocardium and its Mechanisms. Biol. Signals Recept. 8: 316-322, 1999.
12. Lin, L. Z., C. L. Wu, Z. Lu, Y. R. Huang, J. Zhuang and Z. N. Zhou: The Protective Effects of Danshen on the Hypoxia/Reperfusion Injury of Myocardium. Chin. J. Appl. Physiol. (in Chinese) 16(4): 324-326, 2000.

     

13. Zhuang, J. G., Y. Zhang and Z. N. Zhou: Hypoxic Preconditioning Upregulates K_ATP Channels Through Activation of PKC in the Rat Ventricular Myocytes. Acta Pharmacol. Sin. 21(9): 845-849, 2000.

     

14. Moore, L. G., S. Zamudio, J. G. Zhuang, S. Sun and T. Droma: Oxygen Transport in Tibetan Women During Pregnancy at 3,658 m. Am. J. Phys. Anthropol. 114(1): 42-53, 2001.

     

15. Moore, L. G., S. Zamudio, J. G. Zhuang, T. Droma and R. V. Shohet: Analysis of the Myoglobin Gene in Tibetans Living at High Altitude. High Alt. Med. Biol. 3(1): 39-47, 2002.

     

16. Xu, F., J. Zhuang, T. R. Zhou, T. Gibson and D. T. Frazier: Activation of Different Vestibular Subnuclei Evokes Differential Respiratory and Pressor Responses in the Rat. J. Physiol. (Lond.) 544: 211-223, 2002.

     

17. Zhuang, J. G., H. F. Zhu and Z. N. Zhou: Reserved Higher Vagal Tone Under Acute Hypoxia in Tibetan Adolescences Resided at Sea Level for Long Periods. Jpn. J. Physiol. 52(1): 51-56, 2002.

     

18. Xu, F., J. Zhuang, T. Zhou and L.-Y. Lee: Ovalbumin Sensitization Alters the Ventilatory Responses to Chemical Challenges in Guinea Pigs. J. Appl. Physiol. 99(5): 1782-1788, 2005.

     

19. Wang, R., F. Xu, J. Zhuang and C. Zhang: Carotid Sinus Nerve is Involved in Cardiorespiratory Responses to Intracarotid Injection of Capsaicin in the Rat. J. Appl. Physiol. 100(1): 60-66, 2006.

     

20. Zhuang, J., F. Xu, M. Campen, J. Hernandez, S. Shi and R. Wang: Transient Carbon Monoxide Inhibits the Ventilatory Responses to Hypoxia Through Peripheral Mechanisms in the Rat. Life. Sci. 78(22): 2654-2661, 2006.

     

21. Chen, W., X. Wang, J. Zhuang, L. Zhang and Y. Lin: Induction of Death Receptor 5 and Suppression of Survivin Contribute to Sensitization of TRAIL-Induced Cytotoxicity by Quercetin in Non-small Cell Lung Cancer Cells. Carcinogenesis 28(10): 2114-2121, 2007.

     

22. Peng, W., J. Zhuang, K. S. Harrod and F. Xu: Respiratory Syncytial Virus Infection in Anesthetized Weanling Rather than Adult Rats Prolongs the Apneic Responses to Right Atrial Injection of Capsaicin. J. Appl. Physiol. 102(6): 2201-2206, 2007.

     

23. Xu, F., J. Zhuang, R. Wang, JC. Seagrave and T. H. March: Blunted Ventilatory Response to Hypoxia/Hypercapnia in Mice with Cigarette Smoke-Induced Emphysema. Respir. Physiol. Neurobiol. 158(1): 5-13, 2007.