TIPPER, JENNIFER L., PHD

EDUCATION
B.S. (Dietetics and Chemistry) 1975, Marshall University
M.S. (Human Nutrition and Biochemistry) 1976, Purdue University
Ph.D. (Nutritional Biochemistry) 1980, Ohio State University

EMPLOYMENT

2005 - Present Research Associate, Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM
6/99 - 12/04 Research Assistant Professor, Department of Cell Biology and Physiology, Health Sciences Center, University of New Mexico-School of Medicine, Albuquerque, NM
3/92 - 11/98 Research Chemist, GS-12 (step 5), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
2/85 - 3/92 Senior Staff Fellow, National Institute of Mental Health, Bethesda, MD
1/83 - 1/85 Research Fellow in Chemistry, Department of Chemistry and Biochemistry, University of Texas, Austin, TX
8/80 - 12/82 Research Fellow in Medicine, Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA
3/77 - 8/80 Graduate Research Associate, Ohio State University, Columbus, OH
8/75 - 12/76 Graduate Research Associate, Purdue University, W. Lafayette, IN


PROFESSIONAL AFFILIATIONS
American Association for the Advancement of Science
American Diabetes Association
American Society for Matrix Biology

AREAS OF RESEARCH
     Presently studying the immune response in mice to cell wall components and lipids isolated from mycobacteria to characterize the types of granulomatous reactions occurring in TB and correlate those to stages of infection.
     Previous research at UNM involved the study of the structure and function of the abundant proteolipid protein in CNS myelin and its role in myelin integrity. A second project involved characterization of an echinoderm protein, tensilin, which controlled tensile behavior of connective tissue. Cloning and identification of the gene coding for tensilin helped to suggest the mechanism of action of the protein controlling the behavior of this tissue.

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

 

REPRESENTATIVE PUBLICATIONS
(*Also published under the name J. Pierce.)

  1. Binder, F. L. and J. Pierce*: Glycerol Uptake by the Haustorial Mycoparasite Tiegheimomyces parasiticus in Axenic Culture. Can. J. Botany 54: 1403-1409, 1976.

     

  2. Tipper, J. P. and J. B. Allred: Physiological Control of Rat Liver Acetyl-coA Carboxylase. Fed. Proc. 38: 729, 1979.

     

  3. Tipper, J. P., B. A. Ashcraft, G. J. Harris and J. B. Allred: Mechanism of Activation and Properties of Heat Activated Rat Liver Acetyl-coA Carboxylase. Fed. Proc. 29: 2034, 1980.

     

  4. Witters, L. A., S. A. Friedman, J. P. Tipper and G. W. Bacon: Regulation of Acetyl-coA Carboxylase by Guanine Nucleotides. J. Biol. Chem. 256: 8573-8578, 1981.

     

  5. Avruch, J., M. C. Alexander, J. L. Palmer, M. W. Pierce, R. A. Nemenoff, P. J. Blackshear, J. P. Tipper and L. A. Witters: Role of Insulin Action. Fed. Proc. 41: 2629-2633, 1982.

     

  6. Tipper, J. P. and L. A. Witters: Phosphorylation and Inactivation of Rat Liver Acetyl-coA Carboxylase by the cAMP-Dependent Protein Kinase. Biochem. Biophys. Acta 715: 162-169, 1982.

     

  7. Hardesty, B., G. Kramer, E. Wollny, S. Fullilove, G. Zardeneta, S.-C. Chen and J. P. Tipper: Control of Translation by Regulation of Protein Phosphorylation and Dephosphorylation. In Protein Synthesis: Translation and Post-translational Events, The Humana Press, Clifton, NJ, 1983.

     

  8. Tipper, J. P., L. A. Witters and G. W. Bacon: Phosphorylation of Acetyl-coA Carboxylase by Casein Kinase I and Casein Kinase II. Arch. Bioc. Biop. 227: 386-396, 1983.

     

  9. Witters, L. A., J. P. Tipper and G. W. Bacon: Stimulation of Site-Specific Phosphorylation of Acetyl-coA Carboxylase by Insulin and Epinephrine. J. Biol. Chem. 258: 5643-5648, 1983.

     

  10. Fullilove, S., P. Hanke, J. P. Tipper, G. Kramer and B. Hardesty: Distribution of Reticulocyte Regulin. Fed. Proc. 43: 1940, 1984.

     

  11. Tipper, J. P., D. Rose, S.-C. Chen, G. Kramer and B. Hardesty: Characterization of the Fa/Fc Phosphoprotein Phosphatase System from Reticulocytes. Fed. Proc. 43: 1897, 1984.

     

  12. Tipper, J. P., S. Fullilove, G. Kramer and B. Hardesty: Interaction of the 56,000-Dalton Phosphoprotein Phosphatase from Reticulocytes with Regulin and Inhibitor-2. J. Biol. Chem. 261: 7144-7150, 1986.

     

  13. Davis, M. D., P. Ribeiro, J. P. Tipper and S. Kaufman: 7-Tetrahydrobiopterin: A Naturally Occurring Analogue of Tetrahydropterin is a Cofactor for and a Potential Inhibitor of the Aromatic Amino Acid Hydroxylases. Proc. Natl. Acad. Sciences USA 89: 10109-10113, 1992.

     

  14. Tipper, J. P. and S. Kaufman: Phenylalanine-Induced Phosphorylation and Activation of Rat Hepatic Phenylalanine Hydroxylase In Vivo. J. Biol. Chem. 267: 889-896, 1992.

     

  15. Abergel, C., J. P. Tipper and E. A. Padlan: Structural Significance of Sequence Variability in Antibody Complementarity-Determining Regions. Res. Immunol. 145: 149-153, 1994.

     

  16. Tipper, J. P., B. A. Citron, P. Ribeiro and S. Kaufman: Cloning and Expression of Rabbit and Human Brain Tryptophan Hydroxylase cDNA in Escherichia coli. Arch. Biochem. Biophys. 315: 2445-2453, 1994.

     

  17. Padlan, E. A., C. Abergel and J. P. Tipper: Identification of Specificity-Determining Residues in Antibodies. FASEB J. 9: 133-139, 1995.

     

  18. Trotter, J. A., J. P. Tipper, G. Lyons-Levy, K. Chino, A. H. Heuer, Z. Liu, M. Mrksich, C. Hodneland, W. S. Dilmore, T. J. Koob, L. Koob-Emunds, K. Kadler and D. Holmes: Towards a Fibrous Composite with Dynamically Controlled Stiffness. Bioc. Soc. Trans. 28: 357-362, 2000.

     

  19. Tipper, J. P., G. Lyons-Levy, M. A. L. Atkinson and J. A. Trotter: Purification, Characterization and Cloning of Tensilin: The Collagen-Fibril Binding and Tissue-Stiffening Factor from Cucumaria frondosa Dermis. Matrix Biol. 21: 625-635, 2002.
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