BENSON, JANET M., PHD, DABT

EDUCATION
B.S. (Chemistry) 1972, University of California-Berkeley
Ph.D. (Comparative Pharmacology & Toxicology) 1978, University of California-Davis


PROFESSIONAL CERTIFICATION (by examination)
Diplomate, American Board of Toxicology, 1981


EMPLOYMENT

2001 - Present Clinical Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1997 - Present Senior Scientist; Director, Applied Toxicology and Gene Therapy Pharmacology/Toxicity Program (formerly Applied Toxicology Program), Lovelace Respiratory Research Institute, Albuquerque, NM
1989 - 1997 Scientist, Inhalation Toxicology Research Institute, Albuquerque, NM
1987 - 2000 Clinical Associate Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1977 - 1989 Associate Scientist/Toxicologist, Inhalation Toxicology Research Institute, Albuquerque, NM


PROFESSIONAL AFFILIATIONS
American Chemical Society
Society of Toxicology
American Conference of Government Industrial Hygientists
American Society for Gene and Cell Therapy

AREAS OF RESEARCH
Dr. Benson’s areas of research include examining the efficacy, pharmacokinetics/toxicokinetics and safety of potential new therapeutics, including small molecules, natural products, and gene therapies. Her laboratory has developed animal models of ocular, dermal, and pulmonary injury in which to examine the efficacy of new therapeutics. As Principal Investigator of the NHLBI Gene Therapy Resources Program, she assists NHLBI investigators in designing IND-enabling safety and efficacy studies that are implemented at Lovelace. Dr. Benson also has had extensive experience in the design and conduct of inhalation studies, including toxicokinetic and mechanistic evaluations of metals, solvents, natural products, and select agents.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED


REPRESENTATIVE PUBLICATIONS

  1. Kirkpatrick, B., L. E. Fleming, D. Squicciarini, L. C. Backer, R. Clark, W. Abraham, J. Benson, Y. S. Cheng, D. Johnson, R. Pierce, J. Zaias, G. Bossart and D. G. Baden: Literature Review of Red Tide: Implication for Human Health Effects. Harmful Algae 3(2): 99-115, 2004.

     

  2. Langley, R. J., R. Kalra, N. C. Mishra, F. F. Hahn, S. Razani-Boroujerdi, S. P. Singh, J. M. Benson, J. C. Pena-Philippides, E. B. Barr and M. L. Sopori: A Biphasic Response to Silica. I. Immunostimulation is Restricted to the Early Stage of Silicosis in Lewis Rats. Am. J. Respir. Cell Mol. Biol. 30: 823-829, 2004.

     

  3. Benson, J. M., F. F. Hahn, T. H. March, J. D. McDonald, A. P. Gomez, M. L. Sopori, A. J. Bourdelais, J. Naar, J. Zaias, G. D. Bossart and D. G. Baden: Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for Twenty-two Days. Environ. Health Perspect. 113: 626-631, 2005.

     

  4. Benson, J. M., J. A. Hutt, K. Rein, S. E. Boggs, E. B. Barr and L. E. Fleming: The Toxicity of Microcystin LR in Mice Following 7 Days of Inhalation Exposure. Toxicon 45(6): 691-698, 2005.

     

  5. Benson, J. M., B. B. Stagner, G. K. Martin, M. Friedman, S. E. Durr, A. Gomez, J. McDonald, L. E. Fleming, L. C. Backer, D. G. Baden, A. Bourdelais, J. Naar and B. L. Lonsbury-Martin: Cochlear Function in Mice Following Inhalation of Brevetoxin 3. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 191(7): 619-626, 2005.

     

  6. Benson, J. M., A. P. Gomez, G. L. Statom, B. M. Tibbetts, L. E. Fleming, L. E. Backer, A. Reich and D. G. Baden: Placental Transport of Brevetoxin-3 in CD-1 Mice. Toxicon 48(8): 1018-1026, 2006.

     

  7. Tibbetts, B. M., D. G. Baden and J. M. Benson: Uptake, Tissue Distribution, and Excretion of Brevetoxin-3 Administered to Mice by Intratracheal Instillation. J. Toxicol. Environ. Health A 69(14): 1325-1335, 2006.

     

  8. Yan, X., J. M. Benson, A. P. Gomez, D. G. Baden and T. F. Murray: Brevetoxin-Induced Neural Insult in the Retrosplenial Cortex of Mouse Brain. Inhal. Toxicol. 18(14): 1109-1116, 2006.

     

  9. Zhou, Y., J. M. Benson, C. Irvin, H. Irshad and Y. S. Cheng: Particle Size Distribution and Inhalation Dose of Shower Water Under Selected Operating Conditions. Inhal. Toxicol. 19(4): 333-342, 2007.

     

  10. Bogen, K. T., J. M. Benson, G. S. Yost, J. B. Morris, A. R. Dahl, H. J. Clewell, 3rd, K. Krishnan and C. J. Omiecinski: Naphthalene Metabolism in Relation to Target Tissue Anatomy, Physiology, Cytotoxicity and Tumorigenic Mechanism of Action. Regul. Toxicol. Pharmacol. 51(2 Suppl. 1): S27-S36, 2008.

     

  11. North, D. W., K. M. Abdo, J. M. Benson, A. R. Dahl, J. B. Morris, R. Renne and H. Witschi: A Review of Whole Animal Bioassays of the Carcinogenic Potential of Naphthalene. Regul. Toxicol. Pharmacol. 51(2 Suppl. 1): S6-S14, 2008.

     

  12. Fleming, L. E., J. A. Bean, B. Kirkpatrick, Y. S. Cheng, R. Pierce, J. Naar, K. Nierenberg, L. C. Backer, A. Wanner, A. Reich, Y. Zhou, S. Watkins, M. Henry, J. Zaias, W. M. Abraham, J. Benson, A. Cassedy, J. Hollenbeck, G. Kirkpatrick, T. Clarke and D. G. Baden: Exposure and Effects Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma. Environ. Health Perspect. 117(7): 1095-1100, 2009.

     

  13. Chulay, J. D., G.-J. Ye, D. L. Thomas, D. R. Knop, J. M. Benson, J. A. Hutt, G. Wang, M. Humphries and T. R. Flotte: Preclinical Evaluation of a Recombinant Adeno-Associated Virus Vector Expressing Human Alpha-1 Antitrypsin Made Using a Recombinant Herpes Simplex Virus Production Method. Hum. Gene Ther. Dec 12 [Epub ahead of print], 2010.

     

  14. Hicks, A., G. Kourteva, H. Hilton, H. Li, T. A. Lin, W. Liao, Y. Li, X. Wei, T. March, J. Benson and L. M. Renzetti: Cellular and Molecular Characterization of Ozone-Induced Pulmonary Inflammation in the Cynomolgus Monkey. Inflammation 33(3): 144-156, 2010.

     

  15. Mishra, N. C., J. Rir-Sim-Ah, T. March, W. Weber, J. Benson, R. Jaramillo, JC. Seagrave, G. Schultz, G. Grotendorst and M. Sopori: Sulfur Mustard Induces Immune Sensitization in Hairless Guinea Pigs. Int. Immunopharmacol. 10(2): 193-199, 2010.

     

  16. Weber, W. M., D. A. Kracko, M. R. Lehman, C. M. Irvin, L. F. Blair, R. K. White, J. M. Benson, G. R. Grotendorst, Y. S. Cheng and J. D. McDonald: Inhalation Exposure Systems for the Development of Rodent Models of Sulfur Mustard-Induced Pulmonary Injury. Toxicol. Mech. Methods 20(1): 14-24, 2010.

     

  17. Benson, J. M., M. L. Wolf, A. Kajon, B. M. Tibbetts, A. J. Bourdelais, D. G. Baden and T. H. March: Brevetoxin Inhalation Alters the Pulmonary Response to Influenza A in the Male F344 Rat. J. Toxicol. Environ. Health A 74(5): 313-324, 2011.

     

  18. Benson, J. M., A. P. Gigliotti, T. H. March, E. B. Barr, B. M. Tibbetts, B. J. Skipper, C. R. Clark and L. Twerdok: Chronic Carcinogenicity Study of Gasoline Vapor Condensate (GVC) and GVC Containing Methyl Tertiary-Butyl Ether in F344 Rats. J. Toxicol. Environ. Health A (in press).

     

  19. Benson, J. M., JC. Seagrave, W. M. Weber, C. D. Santistevan, G. R. Grotendorst, G. S. Schultz and T. H. March: Time Course of Lesion Development in the Hairless Guinea Pig Model of Sulfur Mustard Induced Dermal Injury. Wound Repair Regen. (in press).

     

  20. Benson, J. M., B. M. Tibbetts, W. M. Weber and G. R. Grotendorst: Uptake, Tissue Distribution, and Excretion of 14C-Sulfur Mustard Vapor Following Inhalation in F344 Rats and Cutaneous Exposure in Hairless Guinea Pigs. J. Toxicol. Environ. Health (in press). 
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