MCDONALD, JACOB D., PHD

EDUCATION
B.S. (Environmental Chemistry) 1996, University of La Verne
Ph.D. (Environmental Chemistry & Toxicology) 2000, University of Nevada

EMPLOYMENT

2/06 - Present Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2004 - Present Director of Chemistry and Inhalation Exposure Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2002 - 2006 Director, Environmental Assessment and Exposures Core, New Mexico NIEHS Center, Albuquerque, NM
2001 - 2004 Supervisor, Analytical Chemistry, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - Present Clinical Assistant Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
10/00 - 2/06 Associate Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2/00 - 9/00 Research Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
3/99 - 1/00 Environmental Chemist, Organic Analytical Lab, Desert Research Institute, Reno, NV
9/96 - 2/99 Graduate Research Assistant, Organic Analytical Lab, Desert Research Institute, Reno, NV
6/95 - 8/95 Analytical Instrument Technician, Chemistry Department, University of La Verne, La Verne, CA
2/95 - 5/95 Laboratory Instructor, Developmental Biology, University of La Verne, La Verne, CA
9/93 - 12/94 Laboratory Instructor, General Biology, University of La Verne, La Verne, CA


PROFESSIONAL AFFILITATIONS
American Association for Aerosol Research
Society of Toxicology
American Chemical Society

AREAS OF RESEARCH
     Dr. McDonald is a Scientist and Program Manager of the Chemistry and Inhalation Exposure Program. The program links aerosol technology with specialized exposure systems to provide inhalation exposures to laboratory animals. The Chemistry Core serves a vital role in characterization of dose formulations, aerosols, and concentrations or fate of chemicals in vivo. Research areas span pharmaceutical, environmental/occupational, and infectious diseases. The pharmaceutical research is primarily focused on preclinical evaluation of formulation, pharmacokinetics, efficacy and safety). The efficacy studies include development and utilization of animal models of COPD, inflammation, fibrosis, mucous, and cancer. Pharmaceutical development also lends into on-going research in the discovery and evaluation of new therapeutics against chemical threats (blister/nerve agents), infectious threats (Biosafety Level-3) and radiological threats.

     The environmental/occupational research focuses primarily in development of inhalation exposure atmospheres that mimic real world exposure conditions. These atmospheres are characterized at a high level of detail to enable research on the relationships between chemical/physical composition and biological response or fate in the body. Occupational hazards, including nanoparticles resulting from the nanotechnology industry, are evaluated for their biological compatibility and fate in vivo.

 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

 

REPRESENTATIVE PUBLICATIONS

  1. McDonald, J. D., M. D. Reed, M. J. Campen, E. G. Barrett, J. Seagrave and J. L. Mauderly: Health Effects of Inhaled Gasoline Engine Emissions. Inhal. Toxicol. 19(Suppl. 1): 107-116, 2007.

     

  2. McDonald, J. D., W. M. Weber, R. Marr, D. Kracko, H. Khain and R. Arimoto: Disposition and Clearance of Tungsten After Single-Dose Oral and Intravenous Exposure in Rodents. J. Toxicol. Environ. Health A 70(10): 829-836, 2007.

     

  3. Meng, Q., D. M. Walker, J. D. McDonald, R. F. Henderson, M. M. Carter, D. L. Cook, Jr., C. L. McCash, S. M. Torres, M. J. Bauer, S. K. Seilkop, P. B. Upton, N. I. Georgieva, G. Boysen, J. A. Swenberg and V. E. Walker: Age-, Gender-, and Species-Dependent Mutagenicity in T Cells of Mice and Rats Exposed by Inhalation to 1,3-Butadiene. Chem. Biol. Interact. 166(1-3): 121-131, 2007.

     

  4. Mitchell, L. A., J. Gao, R. Vander Wal, A. Gigliotti, S. W. Burchiel and J. D. McDonald: Pulmonary and Systemic Immune Response to Inhaled Multiwalled Carbon Nanotubes. Toxicol. Sci. 100(1): 203-214, 2007.

     

  5. Seagrave, J., S. Dunaway, J. D. McDonald, J. L. Mauderly, P. Hayden and C. Stidley: Responses of Differentiated Primary Human Lung Epithelial Cells to Exposure to Diesel Exhaust at an Air-Liquid Interface. Exp. Lung Res. 33(1): 27-51, 2007.

     

  6. Walker, D. M., J. D. McDonald, Q. Meng, D. A. Kracko, M. J. Bauer, S. K. Seilkop, E. L. Walker, R. F. Henderson and V. E. Walker: Measurement of Plasma or Urinary Metabolites and Hprt Mutant Frequencies Following Inhalation Exposure of Mice and Rats to 3-Butene-1,2-diol. Chem. Biol. Interact. 166(1-3): 191-206, 2007.

     

  7. Braun, A., F. E Huggins, A. Kubátová, S. Wirick, M. M. Maricq, B. S. Mun, J. D. McDonald, K. E. Kelly, N. Shah and G. P. Huffman: Toward Distinguishing Woodsmoke and Diesel Exhaust in Ambient Particulate Matter. Environ. Sci. Technol. 42(2): 374-380, 2008.

     

  8. Day, K. C., M. D. Reed, J. D. McDonald, S. K. Seilkop and E. G. Barrett: Effects of Gasoline Engine Emissions on Preexisting Allergic Airway Responses in Mice. Inhal. Toxicol. 20(13): 1145-1155, 2008.

     

  9. Kuehl, P. J., Y. S. Cheng, T. Holmes, H. Irshad, C. L. Leach and J. D. McDonald: Regional Deposition Analysis of a Technetium-99m Labeled Aerosol to Anesthetized Non Human Primates by Planar Gamma Camera Imaging. In Proceedings of Respiratory Drug Delivery 2008, Vol. 2 (R. N. Dalby, P. R. Byron, J. Peart, J. D. Suman, S. J. Farr and P. M. Young, eds.), pp. 601-604, Virginia Commonwealth University, Richmond, VA, 2008.

     

  10. McDonald, J. D., E. B. Barr, R. K. White, D. Kracko, J. C. Chow, B. Zielinska and E. Grosjean: Generation and Characterization of Gasoline Engine Exhaust Inhalation Exposure Atmospheres. Inhal. Toxicol. 20(13): 1157-1168, 2008.

     

  11. Reed, M. D., E. G. Barrett, M. J. Campen, K. K. Divine, A. P. Gigliotti, J. D. McDonald, JC. Seagrave, J. L. Mauderly, S. K. Seilkop and J. A. Swenberg: Health Effects of Subchronic Inhalation Exposure to Gasoline Engine Exhaust. Inhal. Toxicol. 20(13): 1125-1143, 2008.

     

  12. Seagrave, JC., M. J. Campen, J. D. McDonald, J. L. Mauderly and A. C. Rohr: Oxidative Stress, Inflammation, and Pulmonary Function Assessment in Rats Exposed to Laboratory-Generated Pollutant Mixtures. J. Toxicol. Environ. Health A 71(20): 1352-1362, 2008.

     

  13. Weber, W. M., R. Marr, D. Kracko, Z. Gao, J. D. McDonald and K. Ui Chearnaigh: Disposition of Tungsten in Rodents After Repeat Oral and Drinking Water Exposures. Toxicol. Environ. Chem. 90(3): 445-455, 2008.

     

  14. Lauer, F. T., L. A. Mitchell, E. Bedrick, J. D. McDonald, W. Y. Lee, W. W. Li, H. Olvera, M. A. Amaya, M. Berwick, M. Gonzales, R. Currey, N. E. Pingitore, Jr. and S. W. Burchiel: Temporal-Spatial Analysis of U.S.-Mexico Border Environmental Fine and Coarse PM Air Sample Extract Activity in Human Bronchial Epithelial Cells. Toxicol. Appl. Pharmacol. 238(1): 1-10, 2009.

     

  15. Lund, A. K., J. Lucero, S. Lucas, M. C. Madden, J. D. McDonald, JC. Seagrave, T. L. Knuckles and M. J. Campen: Vehicular Emissions Induce Vascular MMP-9 Expression and Activity Associated with Endothelin-1 Mediated Pathways. Arterioscler. Thromb. Vasc. Biol. 29(4): 511-517, 2009.

     

  16. Mitchell, L. A., F. T. Lauer, S. W. Burchiel and J. D. McDonald: Mechanisms for How Inhaled Multiwalled Carbon Nanotubes Suppress Systemic Immune Function in Mice. Nat. Nanotechnol. 4(7): 451-456, 2009.

     

  17. Morishita, M., G. J. Keeler, J. D. McDonald, J. G. Wagner, L.-H. Young, S. Utsunomiya, R. C. Ewing and J. R. Harkema: Source-to-Receptor Pathways of Anthropogenic PM2.5 in Detroit, Michigan: Comparison of Two Inhalation Exposure Studies. Atmos. Environ. 43(10): 1805-1813, 2009.