Harkema, Jack R., DVM, PhD, DACVP

EDUCATION
B.S. (Biology/Chemistry) 1975, Calvin College
M.S. (Mammalian Physiology) 1977, Michigan State University
D.V.M. (Veterinary Medicine) 1980, Michigan State University
Ph.D. (Comparative Pathology) 1985, University of California-Davis


 

PROFESSIONAL CERTIFICATION (by examination)
Veterinary Medicine, State of Michigan, Licensure, 1980
Diplomate, American College of Veterinary Pathologists, 1988



EMPLOYMENT


2003 - Present University Distinguished Professor, Michigan State University, East Lansing, MI
2003 - Present Adjunct Senior Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
1997 - 2002 Senior Fellow, Lovelace Respiratory Research Institute, Albuquerque, NM
1994 - Present Professor (Tenured) of Comparative Pathology, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI
1990 - 1994 Manager, Pathogenesis Program, Inhalation Toxicology Research Institute, Albuquerque, NM
1985 - 1994 Experimental Pathologist, Inhalation Toxicology Research Institute, Albuquerque, NM
1982 - 1985 NIEHS Training Grant Recipient, Resident in Veterinary Pathology, Graduate Student in Comparative Pathology, Department of Pathology, School of Veterinary Medicine, University of California, Davis, CA
1980 - 1982 Postdoctoral Fellow, Physiology, Associated Western Universities, Inhalation Toxicology Research Institute


PROFESSIONAL AFFILIATIONS
American Thoracic Society
American Veterinary Medical Association
Society of Toxicology
Society of Toxicologic Pathologists 

 

AREAS OF RESEARCH
Dr. Harkema's primary research interests are in understanding the cellular and molecular mechanisms responsible for the pathogenesis of airway epithelial injury, adaptation, and repair after exposure to inhaled toxicants. His laboratory team is investigating the roles of inflammatory cells and their mediators in the pathogenesis of airway epithelial alterations (e.g., individual cell necrosis, epithelial hyperplasia, mucous cell metaplasia) in the upper and lower respiratory tract after exposure to various inhaled xenobiotic agents (e.g., ozone, particulate matter, endotoxin, allergens). The long-range goal of these studies is to understand the basic mechanisms of airway cell injury and repair in order to develop interventions to prevent or treat the injurious effects of airborne pollutants. 



REPRESENTATIVE PUBLICATIONS

  1. Boverhof, D. R., L. D. Burgoon, C. Tashiro, B. Chittim, J. R. Harkema, D. B. Jump and T. R. Zacharewski: Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity. Toxicol. Sci. 85(2): 1048-1063, 2005.

     

  2. Elder, A., R. Gelein, J. N. Finkelstein, K. E. Driscoll, J. Harkema and G. Oberdorster: Effects of Subchronically Inhaled Carbon Black in Three Species. I. Retention Kinetics, Lung Inflammation, and Histopathology. Toxicol. Sci. 88(2): 614-629, 2005.

     

  3. Harkema, J. R. and J. G. Wagner: Epithelial and Inflammatory Responses in the Airways of Laboratory Rats Coexposed to Ozone and Biogenic Substances: Enhancement of Toxicant-Induced Airway Injury. Exp. Toxicol. Pathol. 57(Suppl. 1): 129-141, 2005.

     

  4. Kwekel, J. C., L. D. Burgoon, J. W. Burt, J. R. Harkema and T. R. Zacharewski: A Cross-Species Analysis of the Rodent Uterotrophic Program: Elucidation of Conserved Responses and Targets of Estrogen Signaling. Physiol. Genomics 23(3): 327-342, 2005.

     

  5. Boverhof, D. R., L. D. Burgoon, C. Tashiro, B. Sharratt, B. Chittim, J. R. Harkema, D. L. Mendrick and T. R. Zacharewski: Comparative Toxicogenomic Analysis of the Hepatotoxic Effects of TCDD in Sprague Dawley Rats and C57BL/6 Mice. Toxicol. Sci. 94(2): 398-416, 2006.

     

  6. Carter, J. M., N. Corson, K. E. Driscoll, A. Elder, J. N. Finkelstein, J. Harkema, R. Gelein, P. Wade-Mercer, K. Nguyen and G. Oberdorster: A Comparative Dose-Related Response of Several Key Pro- and Antiinflammatory Mediators in the Lungs of Rats, Mice, and Hamsters After Subchronic Inhalation of Carbon Black. J. Occup. Environ. Med. 48(12): 1265-1278, 2006.

     

  7. Crockett, E. T., J. J. Galligan, B. D. Uhal, J. Harkema, R. Roth and K. Pandya: Protection of Early Phase Hepatic Ischemia-Reperfusion Injury by Cholinergic Agonists. BMC Clin. Pathol. 6(1): 3, 2006.

     

  8. Deming, D., T. Sheahan, M. Heise, B. Yount, N. Davis, A. Sims, M. Suthar, J. Harkema, A. Whitmore, R. Pickles, A. West, E. Donaldson, K. Curtis, R. Johnston and R. Baric: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants. PLoS Med. 3(12): e525, 2006.

     

  9. Farraj, A. K., J. R. Harkema and N. E. Kaminski: Topical Application versus Intranasal Instillation: A Qualitative Comparison of the Effect of the Route of Sensitization on Trimellitic Anhydride-Induced Allergic Rhinitis in A/J Mice. Toxicol. Sci. 92(1): 321-328, 2006.

     

  10. Harkema, J. R., S. A. Carey and J. G. Wagner: The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium. Toxicol. Pathol. 34(3): 252-269, 2006.

     

  11. Hyde, D. M., J. R. Harkema, N. K. Tyler and C. G. Plopper: Design-Based Sampling and Quantitation of the Respiratory Airways. Toxicol. Pathol. 34(3): 286-295, 2006.

     

  12. Islam, Z., J. R. Harkema and J. J. Pestka: Satratoxin G from the Black Mold Stachybotrys chartarum Evokes Olfactory Sensory Neuron Loss and Inflammation in the Murine Nose and Brain. Environ. Health Perspect. 114(7): 1099-1107, 2006.

     

  13. Li, M., J. R. Harkema, Z. Islam, C. F. Cuff and J. J. Pestka: T-2 Toxin Impairs Murine Immune Response to Respiratory Reovirus and Exacerbates Viral Bronchiolitis. Toxicol. Appl. Pharmacol. 217(1): 76-85, 2006.

     

  14. Lugo, J., J. R. Harkema, H. deFeijter-Rupp, L. Bartner, D. Boruta and N. E. Robinson: Airway Inflammation is Associated with Mucous Cell Metaplasia and Increased Intraepithelial Stored Mucosubstances in Horses. Vet. J. 172(2): 293-301, 2006.

     

  15. Sirivelu, M. P., S. M. MohanKumar, J. G. Wagner, J. R. Harkema and P. S. MohanKumar: Activation of the Stress Axis and Neurochemical Alterations in Specific Brain Areas by Concentrated Ambient Particle Exposure with Concomitant Allergic Airway Disease. Environ. Health Perspect. 114(6): 870-874, 2006.

     

  16. Carey, S. A., K. R. Minard, L. L. Trease, J. G. Wagner, G. J. Garcia, C. A. Ballinger, J. S. Kimbell, C. G. Plopper, R. A. Corley, E. M. Postlethwait and J. R. Harkema: Three-Dimensional Mapping of Ozone-Induced Injury in the Nasal Airways of Monkeys Using Magnetic Resonance Imaging and Morphometric Techniques. Toxicol. Pathol. 35(1): 27-40, 2007.

     

  17. Keeler, G. J., M. Morishita, J. G. Wagner and J. R. Harkema: Characterization of Urban Atmospheres During Inhalation Exposure Studies in Detroit and Grand Rapids, Michigan. Toxicol. Pathol. 35(1): 15-22, 2007.

     

  18. Li, M., J. R. Harkema, C. F. Cuff and J. J. Pestka: Deoxynivalenol Exacerbates Viral Bronchopneumonia Induced by Respiratory Reovirus Infection. Toxicol. Sci. 95(2): 412-426, 2007.

     

  19. Pottenger, L., L. Malley, M. Bogdanffy, E. Donner, P. Upton, Y. Li, V. Walker, J. Harkema, M. Banton and J. Swenberg: Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene. Toxicol. Sci. Mar 6 [Epub ahead of print], 2007.
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