LRRI is well known for contributing to the understanding of the effects of several environmental xenobiotics on the immune system, including cigarette smoke, silica, diesel exhaust smoke, and beryllium at the organ, cellular, and molecular levels. Our experience and expertise make us ideally suited to evaluate the effects of inhaled toxicants on the immune response of lymphoid tissues and the lung.

 

Key Capabilities:

• NTP-recommended immunotoxicity testing of xenobiotics, under the guidelines of Good Laboratory Practices
• Evaluating the effects of inhaled materials on the cellular traffic in the lung, phagocytosis and clearance of particles and pathogens from the lung, and immune responses in the lung and lung-associated lymph nodes
• Measurement of pulmonary hypersensitivity to inhaled antigens or chemicals and the effects of inhaled toxicants on the development of pulmonary hypersensitivity to environmental allergens
• Evaluating the effects of potential therapeutic drugs on immunological resistance to intracellular and extracellular microorganisms
• Effects of toxicants on cell-cycle and the antigen-mediated signal transduction pathways
• Effects of toxic materials on T cell tolerance and auto-immunity
• Effects of prenatal exposures on the development of lung immunity

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