EDUCATION
B.S. (Zoology) 1993, University of Delhi, India
M.S. (Zoology) 1995, University of Delhi, India
M.Phil. (Biochemistry) 1997, Dept of Zoology, University of Delhi, India
Ph.D. (Biochemistry) 2002, Dept of Zoology, University of Delhi, India
Postdoctoral Fellowship (Pathology) 2005, University of New Mexico 

EMPLOYMENT

HONORS AND AWARDS
Junior Research Fellowship (JRF) from the University Grants Commission (UGC), India and Centre
     for Scientific and Industrial Research (CSIR), India, 1995-1997
Senior Research Fellowship (SRF) from the University Grants Commission (UGC), India and Centre
     for Scientific and Industrial Research (CSIR), India, 1998-2001
A UNM Cancer Research and Treatment Center Translational Research Postdoctoral Matching
     Award, 2004-2005
A 6^th Annual Creative Award by Science and Technology Corporation (STC), UNM, for the US Utility
     Patent Issued on October 7, 2008, U.S. Patent #7,432,238, 2008-2009
A Research Grant Award (#C-2309T) from Research Allocation Committee of UNM Health Science
     Center, 2008-2009
A 7^th Annual Creative Award by Science and Technology Corporation (STC), UNM, for the US Utility
     Patent Issued on September 8, 2009, U.S. Patent #7,585,842, April 2010

PROFESSIONAL AFFILIATIONS
American Thoracic Society
American Society for Microbiology
American Association for Advancement of Sciences
American Society for Biochemistry and Molecular Biology 

AREAS OF RESEARCH
Dr. Chand’s primary research interest is to understand the mechanisms of airway inflammation and remodeling in chronic lung diseases like COPD and asthma, and help develop novel diagnostic and therapeutic approaches. The airway epithelial cells constantly sample the inhaled allergens/antigens and in conjunction with pulmonary dendritic cells shape the appropriate immune responses. The mechanisms involved in eliciting the airway responses and maintaining the airway epithelium homeostasis are being investigated at cellular and molecular levels using various in-vivo animal models of chronic lung diseases and in-vitro human cell culture systems. Current projects include: 1) the role of inflammatory mediators in airway epithelial cell homeostasis, and 2) the mechanisms of airway epithelial cell extrusion using multispectral imaging and live cell imaging techniques. 

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
 

REPRESENTATIVE PUBLICATIONS

1. Ahmad, I., T. Hamid, M. Fatima, H. S. Chand, S. K. Jain, M. Athar and S. Raisuddin: Induction of Hepatic Antioxidants in Freshwater Catfish (Channa punctatus Bloch) is a Biomarker of Paper Mill Effluent. Biochim. Biophys. Acta 1523(1): 37-48, 2000.

    

2. Du, X., H. S. Chand and W. Kisiel: Human Tissue Factor Pathway Inhibitor-2 does not Bind or Inhibit Activated Matrix Metalloproteinase-1. Biochim. Biophys. Acta 1621(3): 242-245, 2003.

    

3. Du, X., F. M. Deng, H. S. Chand and W. Kisiel: Molecular Cloning, Expression, and Characterization of Bovine Tissue Factor Pathway Inhibitor-2. Arch. Biochem. Biophys. 417(1): 96-104, 2003.

    

4. Chand, H. S., X. Du, D. Ma, H. D. Inzunza, S. Kamei, D. Foster, S. Brodie and W. Kisiel: The Effect of Human Tissue Factor Pathway Inhibitor-2 on the Growth and Metastasis of Fibrosarcoma Tumors in Athymic Mice. Blood 103(3): 1069-1077, 2004.

    

5. Chand, H. S., A. E. Schmidt, S. P. Bajaj and W. Kisiel: Structure-Function Analysis of the Reactive Site in the First Kunitz-Type Domain of Human Tissue Factor Pathway Inhibitor-2. J. Biol. Chem. 279(17): 17500-17507, 2004.

    

6. Chand, H. S., R. Chaudhary and K. Muralidhar: A Reference Preparation of Buffalo Pituitary Follicle Stimulating Hormone Using Lectin Affinity Chromatography. Prep. Biochem. Biotechnol. 35(4): 331-345, 2005.

    

7. Chand, H. S., D. C. Foster and W. Kisiel: Structure, Function and Biology of Tissue Factor Pathway Inhibitor-2. Thromb. Haemost. 94(6): 1122-1130, 2005.

    

8. Schmidt, A. E., H. S. Chand, D. Cascio, W. Kisiel and S. P. Bajaj: Crystal Structure of Kunitz Domain 1 (KD1) of Tissue Factor Pathway Inhibitor-2 in Complex with Trypsin: Implications for KD1 Specificity of Inhibition. J. Biol. Chem. 280(30): 27832-27838, 2005.

    

9. Chand, H. S., S. A. Ness and W. Kisiel: Identification of a Novel Human Tissue Factor Splice Variant that is Upregulated in Tumor Cells. Int. J. Cancer 118(7): 1713-1720, 2006.

    

10. Chand, H. S. and W. Kisiel: Quantitative Real-Time Reverse Transcription Polymerase Chain Reaction Analysis of a Novel Tissue Factor Splice Variant in Select Human Solid Tumors. J. Thromb. Haemost. 5(3): 640-641, 2007.

     

11. Kempaiah, P., H. S. Chand and W. Kisiel: Identification of a Human TFPI-2 Splice Variant that is Upregulated in Human Tumor Tissues: A Novel Mechanism for Downregulation of TFPI-2 Expression by Tumor Cells. Mol. Cancer 6(1): 20, 2007.

     

12. Chand, H. S., M. Drysdale, J. Lovchik, T. M. Koehler, M. F. Lipscomb and C. R. Lyons: Discriminating Virulence Mechanisms Among Bacillus anthracis Strains by Using a Murine Subcutaneous Infection Model. Infect. Immun. 77(1): 429-435, 2009.

     

13. Kempaiah, P., H. S. Chand and W. Kisiel: Human Tissue Factor Pathway Inhibitor-2 is Internalized by Cells and Translocated to the Nucleus by the Importin System. Arch. Biochem. Biophys. 482(1-2): 58-65, 2009.

     

14. Chand, H. S., M. Schuyler, N. Joste, C. Hensler, Y. Tesfaigzi, B. Masten, R. Schrader and M. F. Lipscomb: Anti-IgE Therapy Results in Decreased Myeloid Dendritic Cells in Asthmatic Airways. J Allergy Clin. Immunol. Mar 19 [Epub ahead of print].