STOUT-DELGADO, HEATHER, PHD

EDUCATION
B.S. (Microbiology) 2002, University of Texas at Dallas
Ph.D. (Immunology) 2007, University of Texas Southwestern Medical Center
Post-doctoral Training (Geriatrics) 2007-2010, Department of Internal Medicine, Yale University

EMPLOYMENT

2010 - Present Associate Research Scientist, Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2007 - 2010 Post-doctoral Fellow, Internal Medicine (Geriatrics), Yale University, New Haven, CT
2002 - 2007 Doctoral Researcher, University of Texas Southwestern Medical Center, Dallas, TX
2000 - 2001 Researcher, University of Texas at Dallas, Richardson, TX
1999 - 2001 Math Lab Tutor in Calculus I and II, University of Texas at Dallas, Richardson, TX

HONORS
Magna cum Laude, 2002
NIH Ruth L. Kirschstein National Research Service Award: T32 AG019134, 2007
US-Japan Immunosenescence Travel Award, NIAID, 2008
NIH Summer Institute on Aging Research Participant, 2008
Emerging Investigators Conference, Claude D. Pepper Center, 2009



PROFESSIONAL AFFILIATIONS
American Association of Immunologists
New York Academy of Sciences
Golden Key National Honor Society

AREAS OF RESEARCH


  1. Investigation into how the process of aging modifies immune responses to respiratory pathogens, thereby leading to impaired viral clearance, and alterations in long-term immunity to these pathogens.
  2. Examine how aging in the presence of a chronic viral infection impacts immune system function, thereby leading to increased susceptibility of chronically infected hosts to secondary respiratory pathogens.
  3. Examination of innate immune responses to primary influenza viral infections and secondary bacterial infections and how these responses are altered in aged hosts.
  4. Investigate how age induced inflammatory responses alter vaccine efficacy and design of potential therapies to augment innate anti-viral immune function with aging.


REPRESENTATIVE PUBLICATIONS

  1. Barrie, M. B., H. W. Stout, M. S. Abougergi, B. C. Miller and D. L. Thiele: Antiviral Cytokines Induce Hepatic Expression of the Granzyme B Inhibitors, Proteinase Inhibitor 9 and Serine Proteinase Inhibitor 6. J. Immunol. 172: 6453-6459, 2004.

     

  2. Stout-Delgado, H., Y. Getachew, B. Miller and D. Thiele: Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Modulates Hepatic Expression of Serine Protease Inhibitor 6 (Serpinb9/SPI-6). J. Immunol. 179(10): 6561-6567, 2007.

     

  3. Stout-Delgado, H., Y. Getachew, T. Rogers, B. Miller and D. Thiele: The Role of Serpinb9/Serine Protease Inhibitor 6 in Preventing Granzyme B Dependent Hepatotoxicity. Hepatology 46(5): 1530-1540, 2007.

     

  4. Getachew, Y., H. Stout-Delgado, B. Miller and D. Thiele: Granzyme C Supports Efficient CTL-Mediated Killing Late in Primary Alloimmune Responses. J. Immunol. 181(11): 7810-7817, 2008.

     

  5. Stout-Delgado, H. W., X. Yang, W. E. Walker, B. M. Tesar and D. R. Goldstein: Aging Impairs IFN Regulatory Factor 7 Up-Regulation in Plasmacytoid Dendritic Cells During TLR9 Activation. J. Immunol. 181(10): 6747-6756, 2008.

     

  6. Stout-Delgado, H. W., A. C. Shirali, W. Du, C. E. Booth and D. R. Goldstein: Elevated IL-17 Responses with Aging Leads to Neutrophil-Dependent Lethality During Viral Infection. Cell Host Microbe 6(5): 446-456, 2009.