M.D. (Medicine) 1981, Jiangxi Medical College, China
M.S. (Respiratory Physiology) 1985, Shanghai Institute of Physiology, Chinese
     Academy of Sciences, China


2003 - Present Adjunct Associate Professor, Department of Physiology, School of Medicine, University of Kentucky, Lexington, KY
2002 - Present Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1997 - 2002 Assistant Professor, Department of Physiology, University of Kentucky
1994 - 1996 Senior Research Associate, Department of Physiology, University of Kentucky
1991 - 1993 Postdoctoral Scholar, Department of Physiology, University of Kentucky
1989 - 1991 Postdoctoral Research Fellow, CVRI, University of California, San Francisco
1985 - 1989 Research Assistant Professor, Shanghai Institute of Physiology, China
1981 - 1982 Assistant Professor, Department of Physiology, Jiangxi Medical College, China

Society of Neuroscience
The American Physiological Society
American Thoracic Society


Dr. Xu's long-term research objective is to elucidate neural mechanisms involved in the control of breathing under both pathological and physiological conditions. His recent studies focus on:


  1. Roles of cerebellar deep nuclear neurons in respiratory chemoreflexes.
  2. Central neuronal interaction of afferents emanating from carotid chemoreceptors and bronchopulmonary C-fibers in control of breathing.
  3. Toxic inhalation- and pulmonary inflammation-induced peripheral and central neuronal plasticity and respiratory dysfunction.
  4. Neuronal involvement in respiratory/pulmonary (airway) disorders in animal asthmatic and COPD models.

Multidisciplinary approaches (electrophysiological, histological, biological, immunocytochemical and pharmacological) are applied in the above studies to define the relevant neuronal morphological and electrophysiological characteristics, to wire their afferent and efferent pathways, to determine the synaptic transmission and signal interaction.






  1. Xu, F., J. Owen and D. T. Frazier: Cerebellar Modulation of Ventilatory Response to Progressive Hypercapnia. J. Appl. Physiol. 77: 1073-1080, 1994.

  2. Xu, F. and D. T. Frazier: Medullary Respiratory Neuronal Activity Modulated by Stimulation of the Fastigial Nucleus of the Cerebellum. Brain Res. 705: 53-64, 1995.


  3. Xu, F., J. Owen and D. T. Frazier: Hypoxic Respiratory Responses Attenuated by Ablation of the Cerebellum or Fastigial Nuclei. J. Appl. Physiol. 79: 1181-1189, 1995.


  4. Xu, F. and D. T. Frazier: Respiratory-Related Neurons of the Fastigial Nucleus in Response to Chemical and Mechanical Challenges. J. Appl. Physiol. 82: 1177-1184, 1997.


  5. Xu, F. and D. T. Frazier: Involvement of the Fastigial Nuclei in Vagally Mediated Respiratory Responses. J. Appl. Physiol. 82: 1853-1861, 1997.


  6. Xu, F., D. T. Frazier, Z. Zhang, D. M. Baekey and R. Shannon: Cerebellar Modulation of Cough Motor Pattern in Cats. J. Appl. Physiol. 83: 391-397, 1997.


  7. Xu, F., Z. Zhang and D. T. Frazier: Transient Respiratory Augmentation Elicited by Acute Head-Down Tilt in the Anesthetized Cat. J. Appl. Physiol. 85: 490-496, 1998.


  8. Zhang, Z., F. Xu and D. T. Frazier: Role of the Bötzinger Complex in Fastigial Nucleus-Mediated Respiratory Responses. Anat. Rec. 254: 542-548, 1999.


  9. Xu, F. and D. T. Frazier: Modulation of Respiratory Motor Output by Cerebellar Deep Nuclei in the Rat. J. Appl. Physiol. 89: 996-1004, 2000.


  10. Xu, F., Z. Zhang and D. T. Frazier: Microinjection of Acetazolamide into the Fastigial Nucleus Augments Respiratory Output in the Rat. J. Appl. Physiol. 91: 2342-2350, 2001.


  11. Xu, F., T. Zhou, T. Gibson and D. T. Frazier: Fastigial Nucleus-Mediated Respiratory Responses Depend on the Medullary Gigantocellular Nucleus. J. Appl. Physiol. 91: 1713-1722, 2001.


  12. Xu, F., J. Zhuang, T. R. Zhou, T. Gibson and D. T. Frazier: Activation of Different Vestibular Subnuclei Evokes Differential Respiratory Responses in the Rat. J. Physiol. (Lond.) 544: 211-223, 2002.


  13. Xu, F., Q.-H. Gu, T. Zhou and L.-Y. Lee: Acute Hypoxia Prolongs the Apnea Induced by Right Atrial Injection of Capsaicin. J. Appl. Physiol. 94: 1446-1454, 2003.


  14. Hernandez, J. P., F. Xu and D. T. Frazier: Medial Vestibular Nucleus Mediates the Cardiorespiratory Responses to Fatigial Nuclear Activation and Hypercapnia. J. Appl. Physiol. 97(3): 835-842, 2004.


  15. Xu, F., T. Zhou and D. T. Frazier: Purkinje Cell Degeneration Elevates Eupneic and Hypercapnic Ventilation in Rats. Cerebellum 3(3): 133-140, 2004.


  16. Xu, F., J. Zhuang, T. Zhou and L.-Y. Lee: Ovalbumin Sensitization Alters the Ventilatory Responses to Chemical Challenges in Guinea Pigs. J. Appl. Physiol. 99: 1782-1788, 2005.


  17. Wang, R., F. Xu, J. Zhuang and C. Zhang: Carotid Sinus Nerve is Involved in Cardiorespiratory Responses to Intracarotid Injection of Capsaicin in the Rat. J. Appl. Physiol. 100(1): 60-66, 2006.


  18. Wang, R. and F. Xu: Postnatal Development of Right Atrial Injection of Capsaicin-Induced Apenic Response in Rats. J. Appl. Physiol. 101(1): 60-67, 2006.


  19. Zhuang, J., F. Xu, M. Campen, J. Hernandez, S. Shi and R. Wang: Transient Carbon Monoxide Inhibits the Ventilatory Responses to Hypoxia Through Peripheral Mechanisms in the Rat. Life Sci. 78(22): 2654-2661, 2006.


  20. Peng, W., J. Zhuang, K. S. Harrod and F. Xu: Respiratory Syncytial Virus Infection in Anesthetized Weanling Rather Than Adult Rats Prolongs the Apneic Responses to Right Atrial Injection of Capsaicin. J. Appl. Physiol. 102(6): 2201-2206, 2007.


  21. Xu, F., J. Zhuang, R. Wang, JC. Seagrave and T. H. March: Blunted Ventilatory Response to Hypoxia/Hypercapnia in Mice with Cigarette Smoke-Induced Emphysema. Respir. Physiol. Neurobiol. 158(1): 5-13, 2007.


  22. Xu, J., F. Xu, R. Wang, J. Seagrave, Y. Lin and T. H. March: Cigarette Smoke-Induced Hypercapnic Emphysema in C3H Mice is Associated with Increases of Macrophage Metalloelastase and Substance P in the Lungs. Exp. Lung Res. 33(5): 197-215, 2007.


  23. Zhang, Z., F. Xu, C. Zhang and X. Liang: Activation of Opioid m Receptors in Caudal Medullary Raphe Region Inhibits the Ventilatory Response to Hypercapnia in Anesthetized Rats. Anesthesiology 107(2): 288-297, 2007.


  24. Wang, R., F. Xu and J. Liu: Prenatal Hypoxic Preconditioning Improves Hypoxic Ventilatory Response and Reduces Mortality in Neonatal Rats. J. Perinat. Med. 36(2): 161-167, 2008.


  25. Xu, J., F. Xu and E. Barrett: Metalloelastase in Lungs and Alveolar Macrophages is Modulated by Extracellular Substance P in Mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 295(1): L162-L170, 2008.


  26. Zhuang, J., F. Xu and D. T. Frazier: Hyperventilation Evoked by Activation of the Vicinity of the Caudal Inferior Olivary Nucleus Depends on the Fastigial Nucleus in Anesthetized Rats. J. Appl. Physiol. 104(5): 1351-1358, 2008.