EDUCATION
B.S. (Zoology) 1962, Utah State University
M.S. (Zoology) 1964, University of Arizona
Ph.D. (Tropical Medicine) 1968, Louisiana State University Medical Center
 

EMPLOYMENT

PROFESSIONAL AFFILIATIONS
American Association for the Advancement of Science
American Association of Immunologists
American Thoracic Society
Society of Toxicology

AREAS OF RESEARCH
Dr. Bice's goal in research is to identify the differences between pulmonary immune responses that provide protection and immune responses in the lung that cause asthma. To achieve this goal, Dr. Bice and his collaborators are comparing pulmonary immune responses produced to antigen deposited in the lungs of asthmatic and nonasthmatic humans and experimental animals. Antigen-specific IgE antibody responses as well as the production of cytokines important in the regulation of immune responses are being measured. Data from these studies will identify differences in pulmonary immunity that are responsible for asthma. These data may be especially important to identify environmental factors that could alter pulmonary immunity in a way that asthmatic responses would be produced to inhaled allergens, or what exposures could be used to either treat or prevent the development of asthma.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

REPRESENTATIVE PUBLICATIONS

1. Simpson, S. Q., R. Singh and D. E. Bice: Heat-Killed Pneumococci and Pheumococcal Capsular Polysaccharides Stimulate Tumor Necrosis Factor-a Production. Am. J. Respir. Cell Mol. Biol. 10: 284-289, 1994.

    

2. Weissman, D. N., D. E. Bice, R. E. Crowell and M. R. Schuyler: Intrapulmonary Antigen Deposition in the Human Lung: Local Responses. Am. J. Respir. Cell Mol. Biol. 11: 607-614, 1994.

    

3. Bice, D. E. and B. A. Muggenburg: Pulmonary Immune Memory: Localized Production of Antibody in the Lung After Antigen Challenge. Immunology 88: 191-197, 1996.

    

4. Bice, D. E., A. J. Williams and B. A. Muggenburg: Long-Term Antibody Production in Canine Lung Allografts: Implications in Pulmonary Immunity and Asthma. Am. J. Respir. Cell Mol. Biol. 14: 341-347, 1996.

    

5. Collie, D. D. S., D. J. DeBoer, B. A. Muggenburg and D. E. Bice: Evaluation of Association of Blood and Bronchoalveolar Eosinophil Numbers and Serum Total Immunoglobin E Concentration with the Expression of Nonspecific Airway Reactivity in Dogs. Am. J. Vet. Res. 58: 34-39, 1997.

    

6. Schuyler, M., C. R. Lyons, B. J. Masten and D. E. Bice: Immunoglobulin Response to Intrapulmonary Immunization of Asthmatics. Immunology 91: 167-175, 1997.

    

7. Snipes, M. B., J. R. Harkema, J. A. Hotchkiss and D. E. Bice: Neutrophil Involvement in the Retention and Clearance of Dust Intratracheally Instilled into the Lungs of F344/N Rats. Exp. Lung. Res. 23: 65-84, 1997.

    

8. Theodorou, A., N. Weger, K. Kunke, K. Rhee, D. Bice, B. Muggenburg and R. Lemen: Ragweed Sensitization Alters Pulmonary Vascular Responses to Bronchoprovocation in Beagle Dogs. J. Appl. Physiol. 83: 912-917, 1997.

    

9. Bice, D. E.: Chapter 5, Pulmonary Immunology. In Toxicology of the Immune System (D. A. Lawrence, I. G. Sipes, C. A. McQueen and A. J. Gandolfi, eds.), pp. 131-141, Elsevier Scientific Publisher/Pergamon Press, NY, 1998.

    

10. Wilder J. A., D. D. Collie, B. S. Wilson, D. E. Bice, C. R. Lyons and M. F. Lipscomb: Dissociation of Airway Hyperresponsiveness from Immunoglobulin E and Airway Eosinophilia in a Murine Model of Allergic Asthma. Am. J. Respir. Cell Mol. Biol. 20: 1326-1334, 1999.

     

11. Anderson, K. A., R. J. Lemen, N. S. Weger, H. Chen, M. C. Bowers, M. L. Witten, R. C. Lantz, D. E. Bice and B. A. Muggenburg: Nedocromil Sodium Inhibits Canine Adenovirus Bronchiolitis in Beagle Puppies. Toxicol. Pathol. 28: 317-325, 2000.

     

12. Bice, D. E., JC. Seagrave and F. H. Y. Green: Animal Models of Asthma: Potential Usefulness for Studying Health Effects of Inhaled Particles. Inhal. Toxicol. 12: 829-862, 2000.

     

13. Barrett, E. G. and D. E. Bice: Cigarette Smoke and Allergic Asthma: Animal Models. In Environmental Tobacco Smoke: Toxicity, Treatment and Prevention (R. R. Watson and M. Witten, eds.), pp. 337-348, CRC Press LLC, Boca Raton, FL, 2001.

     

14. Redman, T. K., K. Rudolph, E. B. Barr, L. E. Bowen, B. A. Muggenburg and D. E. Bice: Pulmonary Immunity to Ragweed in a Beagle Dog Model of Allergic Asthma. Exp. Lung Res. 27: 433-451, 2001.

     

15. Wang, S. Z., C. L. Rosenberger, T. M. Espindola, E. G. Barrett, Y. Tesfaigzi, D. E. Bice and K. S. Harrod: CCSP Modulates Airway Dysfunction and Host Responses in an Ova-Challenged Mouse Model. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1303-L1311, 2001.

     

16. Wilder, J. A., D. D. S. Collie, D. E. Bice, Y. Tesfaigzi, C. R. Lyons and M. F. Lipscomb: Ovalbumin Aerosols Induce Airway Hyperreactivity in Naïve DO11.10 T Cell Receptor Transgenic Mice Without Pulmonary Eosinophilia or OVA-Specific Antibody. J. Leukoc. Biol. 69(4): 538-547, 2001.

     

17. Barrett, E. G., J. A. Wilder, T. H. March, T. Espindola and D. E. Bice: Cigarette Smoke-Induced Airway Hyperresponsiveness is not Dependent on Elevated Immunoglobulin and Eosinophilic Inflammation in a Mouse Model of Allergic Airway Disease. Am. J. Respir. Crit. Care Med. 165: 1410-1418, 2002.

     

18. Out, T. A., S. Z. Wang, K. Rudolph, T. Redman and D. E. Bice: Local T-Cell Activation After Segmental Allergen Challenge in the Lungs of Allergic Dogs. Immunology 105(4): 499-508, 2002.

     

19. Barrett, E. G., K. Rudolph, L. E. Bowen and D. E. Bice: Parental Allergic Status Influences the Risk of Developing Allergic Sensitization and an Asthmatic-Like Phenotype in Canine Offspring. Immunology 110: 493-500, 2003.

     

20. Barrett, E. G., K. Rudolph, L. E. Bowen, B. A. Muggenburg and D. E. Bice: Effect of Inhaled Ultrafine Carbon Particles on the Allergic Airway Response in Ragweed Sensitized Dogs. Inhal. Toxicol. 15: 151-165, 2003.

     

21. Rudolph, K., D. E. Bice, J. A. Hey and R. L. McLeod: A Model of Allergic Nasal Congestion in Dogs Sensitized to Ragweed. Am. J. Rhinol. 17(4): 227-232, 2003.