EDUCATION
B.S. (Biology) 1994, University of Texas at San Antonio
Ph.D. (Veterinary Molecular Biology) 2003, Montana State University
EMPLOYMENT
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2009 - Present |
Associate Research Scientist, Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM |
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2004 - 2009 |
Postdoctoral Intramural Research Training Award (IRTA) Fellowship, Laboratory of Persistent Viral Diseases/Laboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT |
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1998 - 2004 |
Graduate Research and Teaching Assistant, Veterinary Molecular Biology, Montana State University, Bozeman, MT |
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2006 - 2009 |
Biomedical Research for After School Scholars, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT |
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2004 - 2009 |
Mentoring of summer intern students at Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT |
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2003 |
Graduate Teaching Assistant, Genome Science (VTMB 421) and Functional Gene Expression (VTNB 422), Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT |
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2000 |
Graduate Teaching Assistant, Virology (VTMB 451), Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT |
AWARDS AND TRAINING CERTIFICATES
Using Animals in Intramural Research, 2004
NIH Fellows Award for Research Excellence, 2006
Rocky Mountain Laboratories Biosafety Level 3 Laboratory Training Program, 2007
Emory University Onsite Applied Biosafety Program Biosafety Level 4 Safety Training, 2008
PROFESSIONAL AFFILIATIONS
American Society for Microbiology
American Society for Virology
American Association for the Advancement of Science
Wildlife Disease Association
AREAS OF RESEARCH
The aim of my project is to understand how paramyxoviruses regulate the host innate immune system. IL-6/STAT3 is an important signaling pathway that helps to maintain lung homeostasis during injury. Thus the emphasis of the ongoing research is on how human metapneumovirus and respiratory syncytial virus interacts with the Il-6/STAT3 signaling pathway. By blocking the Il-6/STAT3 signaling pathway, these viruses could perturb the expression of gene regulated by Il-6 (such as acute phase protein, surfactant proteins, and metalomatrix proteins).
ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED
REPRESENTATIVE PUBLICATIONS
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Graff, J. W., D. N. Mitzel, C. M. Weisend, M. L. Flenniken and M. E. Hardy: Interferon Regulatory Factor 3 is a Cellular Partner of Rotavirus NSP1. J. Virol. 76(18): 9545-9550, 2002.
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Mitzel, D. N., C. M. Weisend, M. W. White and M. E. Hardy: Translational Regulation of Rotavirus Gene Expression. J. Gen. Virol. 84(Pt. 2): 383-391, 2003.
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Best, S. M., K. L. Morris, J. G. Shannon, S. J. Robertson, D. N. Mitzel, G. S. Park, E. Boer, J. B. Wolfinbarger and M. E. Bloom: Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-borne Flavivirus and Identification of NS5 as an Interferon Antagonist. J. Virol. 79(20): 12828-12839, 2005.
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Best, S. M., D. N. Mitzel and M. E. Bloom: Action and Reaction: The Arthropod-borne Flaviviruses and Host Interferon Responses. Future Virol. 1(4): 447-459, 2006.
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Mitzel, D. N., J. B. Wolfinbarger, R. D. Long, M. Masnick, S. M. Best and M. E. Bloom: Tick-borne Flavivirus Infection in Ixodes scapularis Larvae: Development of a Novel Method for Synchronous Viral Infection of Ticks. Virology 365(2): 410-418, 2007.
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Mitzel, D. N., S. M. Best, M. Masnick, S. Porcella, J. B. Wolfinbarger and M. E. Bloom: Genetic Correlates of a Tick-borne Flavivirus Associated with Host-Specific Adaptation and Pathogenicity. Virology 381(2): 268-276, 2008.
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Robertson, S. J., D. N. Mitzel, R. T. Taylor, S. M. Best and M. E. Bloom. Tick-borne Flaviviruses: Dissecting Host Immune Responses and Virus Countermeasures. Immunol. Res. 43(1-3): 172-186, 2009.
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Ebenezer, T., D. N. Mitzel, N. E. Maes, S. Mukherjee, C. T. Hanson, S. S. Whitehead and K. A. Hanley: No Role for the Variable Region of Flavivirus 3’ Untranslated Region in Vector Specificity (submitted, 2010).