EDUCATION
  B.S. (Mathematics) 1973, University of Kentucky
  M.S. (Organic Chemistry) 1976, University of Kentucky
  Ph.D. (Pulmonary Toxicology) 1983, Utah State University

PROFESSIONAL CERTIFICATION (by examination)

  Diplomate, American Board of Toxicology, 1986

EMPLOYMENT

PROFESSIONAL AFFILIATIONS
  American Board of Toxicology
  Society of Toxicology (Inhalation {Board of Directors} & Immunotoxicology
  Specialty Sections)
  American Thoracic Society
  International Society for Aerosols in Medicine
  American Association of Pharmaceutical Scientists
  American Diabetic Association
  Pharmaceutical Education & Research Institute (PERI) teaching faculty

AREAS OF RESEARCH
  Pulmonary drug development including therapeutic areas of asthma, rhinitis, COPD, diabetes, antibacterials, antifungals, cystic fibrosis, growth factors, and hormone replacement therapy utilizing technologies such as sustained release biomatrices, PEGylation, novel excipients, and radiolabeled drug distribution.

APPROVED DRUGS/EXCIPIENT DMFs
  QVAR™, Proventil-HFA™, HFA-134a, HFA-227
  Primary responsibility for seven INDs and four NDAs with consultation on many other programs.

ACCESS THIS AUTHOR'S PUBLICATIONS IN PUBMED

REPRESENTATIVE PUBLICATIONS

1. Leach, C. L.: Enhanced Drug Delivery Through Reformulating MDIs with HFA Propellants - Drug Deposition and its Effects on Preclinical and Clinical Programs. In Respiratory Drug Delivery V Proceedings (R. N. Dalby, P. R. Byron and S. J. Farr, ed.), ISBN 1-57491-018-3, pp. 133-144, Interpharm Press, 1996.

    

2. Leach, C. L.: Safety Assessment of the HFA Propellant and the New Inhaler (Airomir™). Eur. Res. J. 7(41): 35-36, 1997.

    

3. Leach, C. L.: Targeting Inhaled Steroids. Int. J. Clin. Pract. Suppl. 96: 23-27, 1998.

    

4. Leach, C. L.: Improved Delivery of Inhaled Steroids to the Large and Small Airways. Respir. Med. 92(Suppl. A): 3-8, 1998.

    

5. Leach, C. L.: Relevance of Radiolabeled Steroid Inhalation Studies to Clinical Outcomes. J. Aerosol Med. 11(1): S29-S34, 1998.

    

6. Leach, C. L., P. J. Davidson and R. J. Boudreau: Improved Airway Targeting with the CFC-Free HFA-Beclomethasone Metered Dose Inhaler Compared with CFC-Beclomethasone. Eur. Res. J. 12: 1346-1353, 1998.

    

7. Davies, R., C. L. Leach, B. Lipworth and R. Shaw: Asthma Management with HFA-BDP. Hosp. Med. 60(4): 263-270, 1999.

    

8. Leach, C. L.: Effect of Formulation Parameters on Hydrofluoroalkane-Beclomethasone Dipropionate Drug Deposition in Humans. J. Allergy Clin. Immunol. 104: S250-S252, 1999.

    

9. Leach, C. L., W. M. Hameister, M.A. Tomai, D. M. Hammerbeck and J. S. Stefely: Oligolactic Acid (OLA) Biomatrices for Sustained Release of Asthma Therapeutics. In Respiratory Drug Delivery VII Proceedings (R. N. Dalby, P. R. Byron, S. J. Farr and J. Peart, eds.), ISBN 1-930114-14-1, pp. 75-81, Serentec Press, Inc., Raleigh, NC, 2000.

    

10. Leach, C. L., P. J. Davidson, B. E. Hasselquist and R. J. Boudreau: Lung Deposition of HFA-Beclomethasone is Greater than that of CFC-Fluticasone and CFC-Beclomethasone: A Cross-Over Study in Healthy Volunteers. Chest 122(2): 510-516, 2002.

     

11. Cherrington, A. D., D. W. Neal, D. S. Edgerton, D. Glass, L. Bowen, C. H. Hobbs, C. Leach, R. Rosskamp and T. R. Strack: Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection. Diabetes 53: 877-881, 2004.

     

12. Edgerton, D. S., D. W. Neal, M. Scott, L. Bowen, W. Wilson, C. H. Hobbs, C. Leach, S. Sivakumaran, T. R. Strack and A. D. Cherrington: Inhalation of Insulin (Exubera) is Associated with Augmented Disposal of Portally Infused Glucose in Dogs. Diabetes 54(4): 1164-1170, 2005.

     

13. Leach, C. L., P. J. Davidson, B. E. Hasselquist and R. J. Boudreau: Influence of Particle Size and Patient Dosing Technique on Lung Deposition of HFA-Beclomethasone from a Metered Dose Inhaler. J. Aerosol Med. 18(4): 379-385, 2005.

     

14. Leach, C. L.: The CFC to HFA Transition and Its Impact on Pulmonary Drug Development. Respir. Care 50(9): 1201-1208, 2005.

     

15. Smyth, H. D. and C. L. Leach: Alternative Propellant Aerosol Delivery Systems. Crit. Rev. Ther. Drug Carrier Syst. 22(6): 493-534, 2005.

     

16. Edgerton, D. S., A. D. Cherrington, P. Williams, D. W. Neal, M. Scott, L. Bowen, W. Wilson, C. H. Hobbs, C. Leach, M. C. Kuo and T. R. Strack: Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo. Diabetes 55(12): 3604-3610, 2006.

     

17. Edgerton, D. S., K. M. Stettler, D. W. Neal, M. Scott, L. Bowen, W. Wilson, C. H. Hobbs, C. Leach, T. R. Strack, and A. D. Cherrington: Inhalation of Human Insulin is Associated with Improved Insulin Action Compared with Subcutaneous Injection and Endogenous Secretion in Dogs. J. Pharmacol. Exp. Ther. 319(3): 1258-1264, 2006.

     

18. Leach, C. L., T. D. Bethke, R. J. Boudreau, B. E. Hasselquist, A. Drollmann, P. Davidson and W. Wurst: Two-Dimensional and Three-Dimensional Imaging Show Ciclesonide has High Lung Deposition and Peripheral Distribution: A Nonrandomized Study in Healthy Volunteers. J. Aerosol Med. 19(2): 117-126, 2006.

     

19. Leach, C. L. and P. LeSouef: Mometasone and Beclomethasone Comparison Article Observations. Chest 129(5): 1389-1390, 2006.

     

20. Roller, C. M., G. Zhang, R. G. Troedson, C. L. Leach, P. N. LeSouëf and S. G. Devadason: Spacer Inhalation Technique and Deposition of Extrafine Aerosol in Asthmatic Children. Eur. Respir. J. 29(2): 299-306, 2007.

     

INTERNATIONAL PATENTS: 5