Lyons, C. Rick, MD, PhD

EDUCATION
B.S. (Biochemistry) 1976, Washington State University
Ph.D. (Micro/Immunology) 1981, University of Texas Southwestern Medical
     Center
M.D. (Medicine) 1987, University of Texas Southwestern Medical Center 

 

EMPLOYMENT

2002 - Present Adjunct Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2000 - Present Associate Professor, Department of Internal Medicine, UNM Cancer Center, University of New Mexico Medical School, Albuquerque, NM
1994 - Present Assistant Professor, Department of Internal Medicine, UNM Cancer Center, University of New Mexico Medical School, Albuquerque, NM
1993 - 1994 Assistant Professor, Department of Internal Medicine, Simmons Cancer Center, University of Texas Southwest Medical Center, Dallas, TX
1991 - 1993 Research Fellow in Medicine, Harvard Medical School
1990 - 1991 Clinical Fellow in Medicine, Hematology/Oncology, Harvard Medical School
1987 - 1989 Internal Medicine Training, Brigham and Women's Hospital, Boston, MA
1983 - 1987 Research Associate, Department of Microbiology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX
1982 - 1983 Postdoctoral Fellow, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX


 

REPRESENTATIVE PUBLICATIONS

  1. Lyons, C. R.: Is There a Role for Infections in Regulating Pulmonary Responses to Allergens? Eur. Respir. Rev. 10: 116-120, 2000.

     

  2. Goade, D. E., R. A. Nofchissey, D. F. Kusewitt, B. Hjelle, J. Kreisel, J. Moore and C. R. Lyons: Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection. Photochem. Photobiol. 74: 108-114, 2001.

     

  3. Wilder, J. A., D. D. Collie, D. E. Bice, Y. Tesfaigzi, C. R. Lyons and M. F. Lipscomb: Ovalbumin Aerosols Induce Airway Hyperreactivity in Naïve DO11.10 T Cell Receptor Transgenic Mice Without Pulmonary Eosinophilia or OVA-Specific Antibody. J. Leukoc. Biol. 69: 538-547, 2001.

     

  4. Bharadwaj, M., K. Mirowsky, C. Ye, J. Botton, B. Masten, J. Yee, C. R. Lyons and B. Hjelle: Genetic Vaccines Protect Against Sin Nombe Hantavirus Challenge in the Deer Mouse (Peromyscus maniculatus). J. Gen. Virol. 83(Pt. 7): 1745-1751, 2002.

     

  5. Howard, S. T., T. F. Byrd and C. R. Lyons: A Polymorphic Region in Mycobacterium abscessus Contains a Novel Insertion. Microbiology 148(Pt. 10): 2987-2996, 2002.

     

  6. Talaat, A. M., S. T. Howard, W. Hale, IV, R. Lyons, H. Garner and S. A. Johnston: Genomic DNA Standards for Gene Expression Profiling in Mycobacterium Tuberculosis. Nucleic Acids Res. 30: e104, 2002.

     

  7. Talaat, A., C. R. Lyons and S. A. Johnston: A Combination Vaccine Confers Full Protection Against Co-infections with Influenza, Herpes Simplex and Respiratory Syntial Viruses. Vaccine 20: 538-544, 2002.

     

  8. Zhang, M., A. Weber, B. Li, R. Lyons, P. R. Contag, A. F. Purchio and D. B. West: An Inducible Nitric Oxide Synthase-Luciferase Reporter System for In Vivo Testing of Anti-inflammatory Compounds in Transgenic Mice. J. Immunol. 170: 6307-6319, 2003.

     

  9. Alam, M. K., J. A. Timlin, L. E. Martin, D. Williams, C. R. Lyons, K. Garrison and B. Hjelle: Spectroscopic Evaluation of Living Murine Macrophage Cells Before and After Activation Using Attenuated Total Reflectance Infrared Spectroscopy. Vibrational Spectroscopy 34: 3-11, 2004.

     

  10. Belosludtsev, Y. Y., D. Bowerman, R. Weil, N. Marthandan, R. Balog, K. Luebke, J. Lawson, S. A. Johnston, C. R. Lyons, K. Obrien, H. R. Garner and T. F. Powdrill: Organism Identification Using a Genome Sequence-Independent Universal Microarray Probe Set. Biotechniques 37(4): 654-658, 2004.

     

  11. Chicoine, L. G., E. Tzeng, R. Bryan, S. Saenz, M. L. Paffett, J. Jones, C. R. Lyons, T. C. Resta, L. D. Nelin and B. R. Walker: Intratracheal Adenoviral-Mediated Delivery of iNOS Decreases Pulmonary Vasoconstrictor Responses in Rats. J. Appl. Physiol. 97(5): 1814-1822, 2004.

     

  12. Kozel, T. R., W. J. Murphy, S. Brandt, B. R. Blazar, J. A. Lovchik, P. Thorkildson, A. Percival and C. R. Lyons: mAbs to Bacillus anthracis Capsular Antigen for Immunoprotection in Anthrax and Detection of Antigenemia. Proc. Natl. Acad. Sci. USA 101(14): 5042-5047, 2004.

     

  13. Lyons, C. R., J. Lovchik, J. Hutt, M. F. Lipscomb, E. Wang, S. Heninger, L. Berliba and K. Garrison: Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility. Infect. Immun. 72(8): 4801-4809, 2004.

     

  14. Talaat, A. M., R. Lyons, S. T. Howard and S. A. Johnston: The Temporal Expression Profile of Mycobacterium tuberculosis Infection in Mice. Proc. Natl. Acad. Sci. USA 101(13): 4602-4607, 2004.

     

  15. Drysdale, M., S. Heninger, J. Hutt, Y. Chen, C. R. Lyons and T. M. Koehler: Capsule Synthesis by Bacillus anthracis is Required for Dissemination in Murine Inhalation Anthrax. EMBO J. 24(1): 221-227, 2005.

     

  16. Wright, A., A. Semyonov, G. Dawes, A. Crameri, R. Lyons, W. P. Stemmer, D. Apt and J. Punnonen: Diverse Plasmid DNA Vectors by Directed Molecular Evolution of Cytomegalovirus Promoters. Hum. Gene Ther. 16(7): 881-892, 2005.

     

  17. Wu, T. H., J. A. Hutt, K. A. Garrison, L. S. Berliba, Y. Zhou and C. R. Lyons: Intranasal Vaccination Induces Protective Immunity Against Intranasal Infection with Virulent Francisella tularensis Biovar A. Infect. Immun. 73(5): 2644-2654, 2005.

     

  18. Apt, D., K. Raviprakash, A. Brinkman, A. Semyonov, S. Yang, C. Skinner, L. Diehl, R. Lyons, K. Porter and J. Punnonen: Tetravalent Neutralizing Antibody Response Against Four Dengue Serotypes by a Single Chimeric Dengue Envelope Antigen. Vaccine 24(3): 335-344, 2006.

     

  19. Heninger, S., M. Drysdale, J. Lovchik, J. Hutt, M. F. Lipscomb, T. M. Koehler and C. R. Lyons: Toxin-Deficient Mutants of Bacillus anthracis are Lethal in a Murine Model for Pulmonary Anthrax. Infect. Immun. 74(11): 6067-6074, 2006.

     

  20. Hermann, J. E., S. Wang, C. Zhang, R. G. Panchal, S. Bavari, C. R. Lyons, J. A. Lovchik, B. Golding, J. Shiloach and S. Lu: Passive Immunotherapy ofBacillus anthracis Pulmonary Infection in Mice with Antisera Produced by DNA Immunization. Vaccine 24(31-32): 5872-5880, 2006.

     

  21. Howard, S. T., E. Rhoades, J. Recht, X. Pang, A. Alsup, R. Kolter, C. R. Lyons and T. F. Byrd: Spontaneous Reversion of Mycobacterium abscessus from a Smooth to a Rough Morphotype is Associated with Reduced Expression of Glycopeptidolipid and Reacquisition of an Invasive Phenotype. Microbiology 152(Pt. 6): 1581-1590, 2006.

     

  22. Stanley, K. P., L. G. Chicoine, T. L. Young, K. M. Reber, C. R. Lyons, Y. Liu and L. D. Nelin: Gene Transfer with Inducible Nitric Oxide Synthase Decreases Production of Urea by Arginase in Pulmonary Arterial Endothelial Cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 290(2): L298-L306, 2006.

     

  23. Drysdale, M., G. Olson, T. M. Koehler, M. F. Lipscomb and C. R. Lyons: Murine Innate Immune Response to Virulent Toxigenic and Nontoxigenic Bacillus anthracis Strains. Infect. Immun. 75(4): 1757-1764, 2007.

     

  24. Harris, J. F., J. Aden, C. R. Lyons and Y. Tesfaigzi: Resolution of LPS-Induced Airway Inflammation and Goblet Cell Hyperplasia is Independent of IL-18.Respir. Res. 8: 24, 2007.

     

  25. Kozel, T. R., P. Thorkildson, S. Brandt, W. H. Welch, J. A. Lovchik, D. P. AuCoin, J. Vilai and C. R. Lyons: Protective and Immunochemical Activities of Monoclonal Antibodies Reactive with the Bacillus anthracis Polypeptide Capsule. Infect. Immun. 75(1): 152-163, 2007.

     

  26. Lawson, J. N., C. R. Lyons and S. A. Johnston: Expression Profiling of Yersinia pestis During Mouse Pulmonary Infection. DNA Cell Biol. 25(11): 608-616, 2007.

     

  27. Lyons, R. and T. Wu: Animal Models of Francisella tularensis Infection. Ann. NY Acad. Sci. Mar 29 [Epub ahead of print], 2007.

     

  28. Talaat, A. M., S. K. Ward, C. W. Wu, E. Rondon, C. Tavano, J. P. Bannantine, R. Lyons and S. A. Johnston: Mycobacterial bacilli are Metabolically Active During Chronic Tuberculosis in Murine Lungs: Insights from Genome-Wide Transcriptional Profiling. J. Bacteriol. Mar 23 [Epub ahead of print], 2007.
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