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SEAGRAVE, JEANCLARE, PHD CONTACT INFORMATION Fax: (505) 348-8567 e-mail: jseagrav@LRRI.org Extended CV

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EDUCATION
B.S. with Honors (Biology) 1976, California Institute of Technology
Ph.D. (Medical Sciences/Biochemistry) 1981, University of New Mexico

EMPLOYMENT

2009 - Present	Manager, ALIVE/Cell Toxicology, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - Present	Clinical Associate Professor, Department of Pathology, University of New Mexico, Albuquerque, NM
2001 - Present	Clinical Assistant Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1996 - Present	Associate Scientist, Experimental Toxicology Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1993 - 1995	Program Director, Secretory Physiology Program, Institute for Basic and Applied Medical Research, The Lovelace Institutes, Albuquerque, NM
1989 - 2001	Adjunct Assistant Professor of Pathology, University of New Mexico School of Medicine, Albuquerque, NM
1989 - 1996	Associate Scientist, Institute for Basic and Applied Medical Research, The Lovelace Institutes, Albuquerque, NM
1985 - 1989	Research Assistant Professor, Department of Pathology, UNM School of Medicine
1984 - 1985	Research Associate, Department of Pathology, University of New Mexico
1981 - 1984	Postdoctoral Fellow, Genetics Group, Life Sciences Division, Los Alamos National Laboratory

PROFESSIONAL AFFILIATIONS
Society of Toxicology
American Society for Cell Biology
American Physiological Society
New York Academy of Sciences
American Association for the Advancement of Science
Sigma Xi

AREAS OF RESEARCH
Dr. Seagrave's primary research activities focus on the structural, functional, and biochemical responses of the lung to air pollution constituents. She is particularly interested in the interactions between the cells of the immune system and the epithelium. Current projects include assessing the relative toxicity of emissions from vehicles with gasoline or diesel engines and elucidating the mechanisms by which cigarette smoke causes emphysema. Model systems include inhalation and intratracheal instillation in experimental animals, and exposure of cultured cells to suspended materials in conventional tissue culture and to aerosol materials in an air-liquid interface culture system.

REPRESENTATIVE PUBLICATIONS

1. Seagrave, JC., J. D. McDonald, E. Bedrick, E. S. Edgerton, A. P. Gigliotti, J. J. Jansen, L. Ke, L. P. Naeher, S. K. Seilkop, M. Zheng and J. L. Mauderly: Lung Toxicity of Ambient Particulate Matter from Southeastern U.S. Sites with Different Contributing Sources: Relationships Between Composition and Effects. Environ. Health Perspect. 114(9): 1387-1393, 2006.

2. Lund, A. K., T. L. Knuckles, C. Obot Akata, R. Shohet, J. D. McDonald, A. Gigliotti, JC. Seagrave and M. J. Campen: Gasoline Exhaust Emissions Induce Vascular Remodeling Pathways Involved in Atherosclerosis. Toxicol Sci. 95(2): 485-494, 2007.

3. McDonald, J. D., M. D. Reed, M. J. Campen, E. G. Barrett, J. Seagrave and J. L. Mauderly: Health Effects of Inhaled Gasoline Engine Emissions. Inhal. Toxicol. 19(Suppl. 1): 107-116, 2007.

4. Seagrave, J., S. Dunaway, J. D. McDonald, J. L. Mauderly, P. Hayden and C. Stidley: Responses of Differentiated Primary Human Lung Epithelial Cells to Exposure to Diesel Exhaust at an Air-Liquid Interface. Exp. Lung Res. 33(1): 27-51, 2007.

5. Stout, B. A., K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang and Y. Tesfaigzi: STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum During the Resolution of Airway Mucous Cell Hyperplasia by IFN-g. J. Immunol. 178(12): 8107-8116, 2007.

6. Xu, F., J. Zhuang, R. Wang, JC. Seagrave and T. H. March: Blunted Ventilatory Response to Hypoxia/Hypercapnia in Mice with Cigarette Smoke-Induced Emphysema. Respir. Physiol. Neurobiol. 158(1): 5-13, 2007.

7. Xu, J., F. Xu, R. Wang, J. Seagrave, Y. Lin and T. H. March: Cigarette Smoke-Induced Hypercapnic Emphysema in C3H Mice is Associated with Increases of Macrophage Metalloelastase and Substance P in the Lung. Exp. Lung Res. 33(5): 197-215, 2007.

8. Reed, M. D., E. G. Barrett, M. J. Campen, K. K. Divine, A. P. Gigliotti, J. D. McDonald, JC. Seagrave, J. L. Mauderly, S. K. Seilkop and J. A. Swenberg: Health Effects of Subchronic Inhalation Exposure to Gasoline Engine Exhaust. Inhal. Toxicol. 20(13): 1125-1143, 2008.

9. Seagrave, J.: Mechanisms and Implications of Air Pollution Particle Associations with Chemokines. Toxicol. Appl. Pharmacol. 232(3): 469-477, 2008.

10. Seagrave, J., M. J. Campen, J. D. McDonald, J. L. Mauderly and A. C. Rohr: Oxidative Stress, Inflammation, and Pulmonary Function Assessment in Rats Exposed to Laboratory-Generated Pollutant Mixtures. J. Toxicol. Environ. Health A 71(20): 1352-1362, 2008.

11. Adenuga, D., H. Yao, T. H. March, J. Seagrave and I. Rahman: Histone Deacetylase 2 is Phosphorylated, Ubiquitinated, and Degraded by Cigarette Smoke. Am. J. Respir. Cell Mol. Biol. 40(4): 464-473, 2009.

12. BéruBé, K., M. Aufderheide, D. Breheny, R. Clothier, R. Combes, R. Duffin, B. Forbes, M. Gaça, A. Gray, I. Hall, M. Kelly, M. Lethem, M. Liebsch, L. Merolla, J. P. Morin, J. Seagrave, M. A. Swartz, T. D. Tetley and M. Umachandran: In Vitro Models of Inhalation Toxicity and Disease, the Report of a FRAME Workshop. Altern. Lab Anim. 37(1): 89-141, 2009.

13. Lund, A. K., J. Lucero, S. Lucas, S., M. C. Madden, J. D. McDonald, JC. Seagrave, T. L. Knuckles and M. J. Campen: Vehicular Emissions Induce Vascular MMP-9 Expression and Activity Associated with Endothelin-1-Mediated Pathways. Arterioscler. Thromb. Vasc. Biol. 29(4): 511-517, 2009.

14. Sood, A., C. Qualls, J. Seagrave, C. Stidley, M. Berwick, T. Archibeque and M. Schuyler: Effect of Specific Allergen Inhalation on Serum Adiponectin in Human Asthma. Chest 135(2): 287-294, 2009.

15. Campen, M. J., A. K. Lund, T. L. Knuckles, D. J. Conklin, B. Bishop, D. Young, S. Seilkop, J. Seagrave, M. D. Reed and J. D. McDonald: Inhaled Diesel Emissions Alter Atherosclerotic Plaque Composition in ApoE^-/- Mice. Toxicol. Appl. Pharmacol. 242(3): 310-317, 2010.

16. McDonald, J. D., M. Doyle-Eisele, M. J. Campen, J. Seagrave, T. Holmes, A. Lund, J. D. Surratt, J. H. Seinfeld, A. C. Rohr and E. M. Knipping: Cardiopulmonary Response to Inhalation of Biogenic Secondary Organic Aerosol. Inhal. Toxicol. 22(3): 253-265, 2010.

17. Mishra, N. C., J. Rir-Sim-Ah, T. March, W. Weber, J. Benson, R. Jaramillo, JC. Seagrave, G. Schultz, G. Grotendorst and M. Sopori: Sulfur Mustard Induces Immune Sensitization in Hairless Guinea Pigs. Int. Immunopharmacol. 10(2): 193-199, 2010.

18. Olivera, D., C. Knall, S. Boggs and J. Seagrave: Cytoskeletal Modulation and Tyrosine Phosphorylation of Tight Junction Proteins are Associated with Mainstream Cigarette Smoke-Induced Permeability of Airway Epithelium. Exp. Toxicol. Pathol. 62(2): 133-143, 2010.

19. Pickett, G., J. Seagrave, S. Boggs, G. Polzin, P. Richter and Y. Tesfaigzi: Effects of 10 Cigarette Smoke Condensates on Primary Human Airway Epithelial Cells by Comparative Gene and Cytokine Expression Studies. Toxicol. Sci. 114(1): 79-89, 2010.