return to directory

HARROD, KEVIN S., PHD CONTACT INFORMATION Fax: (505) 348-8567 e-mail: kharrod@LRRI.org Extended CV

---

EDUCATION
B.S. (Biology) 1989, University of Kentucky
Ph.D. (Pharmacology) 1995, University of Kentucky

EMPLOYMENT

2003 - Present	Director, Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2003 - Present	Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - 2003	Associate Staff Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
2001 - Present	Clinical Assistant Professor, Department of Pathology and College of Pharmacy, University of New Mexico, Albuquerque, NM
1999 - 2001	Associate Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1994 - 1999	New Investigator NHLBI Program of Excellence in Molecular Biology of the Heart and Lung, Division of Pulmonary Biology, Children's Hospital Research Foundation, Children's Hospital Medical Center, Cincinnati, OH

PROFESSIONAL AFFILIATIONS

Center for Infectious Disease and Immunity, University of New Mexico
Infectious Disease and Inflammation Program, Dept. of Pathology, University of New Mexico Aerobiology Center,
     University of New Mexico
NIEHS Center, Full Member
Clinical Assistant Professor, Department of Pathology, University of New Mexico
Clinical Assistant Professor, College of Pharmacy, University of New Mexico
American Thoracic Society
American Physiological Society
Society of Toxicology, Full Member

AREAS OF RESEARCH
Current research interests include the development of animal models to explore the role of the lung epithelium in innate immunity and host defense to viral and bacterial infection. Strategies include the use of lung-specific transgenic and gene targeting technology to produce "gain of function" and "loss of function" models to delineate important mechanisms that modulate lung responses to infection.

REPRESENTATIVE PUBLICATIONS

1. Towne, J. E., K. S. Harrod, C. M. Krane and A. G. Menon: Decreased Expression of Aquaporin (AQP)1 and AQP5 in Mouse Lung After Acute Viral Infection. Am. J. Respir. Cell Mol. Biol. 22(1): 34-44, 2000.

2. Wang, S. Z., C. L. Rosenberger, T. M. Espindola, E. G. Barrett, Y. Tesfaigzi, D. E. Bice and K. S. Harrod: CCSP Modulates Airway Dysfunction and Host Responses in an Ova-Challenged Mouse Model. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1303-L1311, 2001.

3. Harrod, K. S. and R. J. Jaramillo: Pseudomonas aeruginosa and Tumor Necrosis Factor-a Attenuate Clara Cell Secretory Protein Promoter Function. Am. J. Respir. Cell Mol. Biol. 26: 216-223, 2002.

4. Harrod, K. S., R. J. Jaramillo, C. L. Rosenberger, S. Z. Wang, J. A. Berger, J. D. McDonald and M. D. Reed: Increased Susceptibility to RSV Infection by Exposure to Inhaled Diesel Engine Emissions. Am. J. Respir. Cell Mol. Biol. 28: 451-463, 2003.

5. Kajon, A. E., A. Gigliotti and K. S. Harrod: Acute Inflammatory Response and Remodeling of Airway Epithelium After Subspecies B1 Human Adenovirus Infection on the Mouse Lower Respiratory Tract. J. Med. Virol. 71: 233-244, 2003.

6. Wang, S. Z., C. L. Rosenberger, Y.-X. Bao, J. M. Stark and K. S. Harrod: Clara Cell Secretory Protein Modulates Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection. J. Immunol. 171(12): 1051-1060, 2003.

7. Alvarez, R., K. S. Harrod, W.-J. Shieh, S. Zaki and R. A. Tripp: Human Metapneumovirus Persists in BALB/c Mice Despite the Presence of Neutralizing Antibodies. J. Virol. 78(24): 14003-14011, 2004.

8. McDonald, J. D., K. S. Harrod, JC. Seagrave, S. K. Seilkop and J. L. Mauderly: Effects of Low Sulfur Fuel and a Catalyzed Particle Trap on the Composition and Toxicity of Diesel Emissions. Environ. Health Perspect. 112(13): 1307-1312, 2004.

9. Wang, S. Z., Y.-X. Bao, C. L. Rosenberger, Y. Tesfaigzi, J. M. Stark and K. S. Harrod: IL-12p40 and IL-18 Modulate Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection. J. Immunol. 173: 4040-4049, 2004.

10. Bohn, A. A., K. S. Harrod, S. Teske and B. P. Lawrence: Increased Mortality Associated with TCDD Exposure in Mice Infected with Influenza A Virus is Not Due to Severity of Lung Injury or Alterations in Clara Cell Protein Content. Chem. Biol. Interact. 155(3): 181-190, 2005.

11. Harrod, K.: Epithelial Pathogen Interactions in the Aged Lung. Exp. Lung Res. 31(Suppl. 1):79, 2005.

12. Harrod, K. S., R. J. Jaramillo, J. A. Berger, A. P. Gigliotti, S. K. Sielkop and M. D. Reed: Inhaled Diesel Engine Emissions Reduce Bacterial Clearance and Exacerbate Lung Disease to Pseudomonas aeruginosa Infection In Vivo. Toxicol. Sci. 83(1): 155-165, 2005.

13. Duta, F., M. Ulanova, D. Seidel, L. Puttagunta, S. Musat-Marcu, K. S. Harrod, A. D. Schreiber, U. Steinhoff and A. D. Befus: Differential Expression of Isoforms of Spleen Tyrosine Kinase Syk in Tissues: Effects of Microbial Flora. Histochem. Cell Biol. 126(4): 495-505, 2006.

14. Phaybouth V., S. Z. Wang, J. A. Hutt, J. D. McDonald, K. S. Harrod and E. G. Barrett: Cigarette Smoke Suppresses Th1 Cytokine Production and Increases RSV Expression in a Neonatal Model. Am. J. Physiol. Lung Cell. Mol. Physiol. 290(2): L222-L231, 2006.

15. Reed, M. D., M. J. Campen, A. P. Gigliotti, K. S. Harrod, J. D. McDonald, JC. Seagrave, J. L. Mauderly and S. K. Seilkop: Health Effects of Subchronic Exposure to Environmental Levels of Hardwood Smoke. Inhal. Toxicol. 18(8): 523-539, 2006.

16. Wang, S. Z. and K. S. Harrod: The Immunobiology of Respiratory Syncytial Virus Infection. Solicitated Review. Clin. Applied Immunol. Rev. 6: 37-52, 2006.

17. Lei, W., R. J. Jaramillo and K. S. Harrod: Transactivation of Lung Lysozyme Expression by Ets Family Member ESE-1. Am. J. Physiol. Lung Cell. Mol. Physiol. 293(5): L1359-L1368, 2007.

18. Martinez, M. J., A. D. Smith, B. Li, M. Q. Zhang and K. S. Harrod: Computational Prediction of Novel Components of Lung Transcriptional Networks. Bioinformatics 23(1): 21-29, 2007.

19. Peng, W., J. Zhuang, K. S. Harrod and F. Xu: Respiratory Syncytial Virus Infection in Anesthetized Weanling Rather Than Adult Rats Prolongs the Apneic Responses to Right Atrial Injection of Capsaicin. J. Appl. Physiol. 102(6): 2201-2206, 2007.

20. Chu, Y. K., G. D. Ali, F. Jia, Q. Li, D. Kelvin, R. C. Couch, K. S. Harrod, J. A. Hutt, C. Cameron, S. R. Weiss and C. B. Jonsson: The SARS-CoV Ferret Model in an Infection-Challenge Study. Virology 374(1): 151-163, 2008.

21. Dinwiddie, D. L. and K. S. Harrod: Human Metapneumovirus Inhibits IFN-a Signaling Through Inhibition of STAT1 Phosphorylation. Am. J. Respir. Cell Mol. Biol. 38(6): 661-670, 2008.

22. Husain, M. and K. S. Harrod: Influenza A Virus-Induced Caspase-3 Cleaves the Histone Deacetylase 6 in Infected Epithelial Cells. FEBS Lett. Jul 10 [Epub ahead of print], 2009.

23. Senft, A. P., R. H. Taylor, W. Lei, S. A. Campbell, J. L. Tipper, M. J. Martinez, T. L. Witt, C. C. Clay and K. S. Harrod: RSV Impairs Macrophage IFN-a/ß- and IFN-g-Stimulated Transcription by Distinct Mechanisms. Am. J. Respir. Cell Mol. Biol. Jun 5 [Epub ahead of print], 2009.