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GROTENDORST, GARY R., PHD CONTACT INFORMATION Fax: (505) 348-8567 e-mail: ggrotend@lrri.org Extended CV

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EDUCATION
B.A. (Biology) 1974, University of South Florida
Ph.D. (Biology) 1979, University of South Florida

EMPLOYMENT

2007 - Present	Director of Countermeasures Against Chemical Threats (CounterACT) Research Center of Excellence, Lovelace Respiratory Research Institute, Albuquerque, NM
2004 - Present	Senior Scientist, Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM
1993 - 2004	Professor, University of Miami School of Medicine, Department of Cell Biology and Anatomy
1991 - 1993	Associate Professor, University of Miami School of Medicine, Department of Cell Biology and Anatomy
1989 - 1991	Associate Professor, USF College of Medicine, Dept. of Ophthalmology and Department of Biochemistry and Molecular Biology, Tampa, FL
1987 - 1989	Associate Professor, University of South Florida, Department of Biology, Tampa, FL
1984 - 1987	Assistant Professor, Medical University of South Carolina, Division of Rheumatology and Immunology
1982 - 1984	Staff Fellow, Laboratory of Developmental Biology and Anomalies, NIDR, Bethesda, MD
1979 - 1982	Postdoctoral Fellow NRSA, Laboratory of Departmental Biology and Anomalies, NIDR, Bethesda, MD

PROFESSIONAL AFFILIATIONS
Wound Healing Society

AREAS OF RESEARCH
My current research interests revolve around the biology of connective tissue growth factor (CTGF). CTGF, which was originally discovered in my laboratory, has been demonstrated to function as a regulatory factor in the development of normal connective tissue during embryogenesis, the regeneration of connective tissue during normal wound repair, and in the overgrowth of connective tissue in fibrotic disorders including atherosclerosis, arthritis, burn scars, pulmonary fibrosis, kidney fibrosis, scleroderma, keloids and inflammatory bowel disease. CTGF is also overexpressed in the stroma of malignant and metastatic tumors. At the present our laboratory's research is focused on the role of CTGF as a regulator of cell proliferation and differentiation. These studies involve investigations into the regulation of CTGF gene expression, the identification and characterization of CTGF receptor(s), the actions of this molecule in both normal and pathological processes, and the signaling mechanisms through which CTGF mediates its actions on target cells. Recently, our investigations have identified a new aspect of CTGF function during lung development. Our studies indicate that CTGF plays a role in the differentiation of the lung epithelial cells and appears to regulate the formation of alveoli. Accordingly, we are expanding or research program to further investigate this very important finding. The cell biological processes that we are very interested in regarding our CTGF research program include cell cycle control, differentiation, intracellular trafficking, receptor-based signaling, collagen synthesis and assembly, cell adhesion and migration, and gene regulation.

REPRESENTATIVE PUBLICATIONS

1. Grotendorst, G. R.: Connective Tissue Growth Factor: A Mediator of TGF-b Action on Fibroblasts. Cytokine Growth Factor Rev. 8: 171-179, 1997.

2. Kothapalli, D., K. S. Frazier, A. Welply, P. R. Segarini and G. R. Grotendorst: Transforming Growth Factor Beta Induces Anchorage-Independent Growth of NRK Fibroblasts via a Connective Tissue Growth Factor-Dependent Signaling Pathway. Cell Growth Differ. 8: 61-68, 1997.

3. Mason, E. D., S. Williams, G. R. Grotendorst and J. L. Marsh: Combinatorial Signaling by Twisted Gastrulation and Decapentaplegic. Mech. Dev. 64: 61-75, 1997.

4. Kothapalli, D., N. Hayashi and G. R. Grotendorst: Inhibition of TGF-b-Stimulated CTGF Gene Expression and Anchorage-Independent Growth by cAMP Identifies a CTGF-Dependent Restriction Point in the Cell Cycle. FASEB J. 12: 1151-1161, 1998.

5. Duncan, M. R., K. S. Frazier, S. Abramson, S. Williams, H. Klapper, X. Huang and G. R. Grotendorst: Connective Tissue Growth Factor Mediates Transforming Growth Factor b-Induced Collagen Synthesis: Down-Regulation by cAMP. FASEB J. 13: 1774-1786, 1999.

6. Grotendorst, G. R., L. F. Lau and B. Perbal: CCN Proteins are Distinct from and should not be Considered Members of the Insulin-Like Growth Factor-Binding Protein Superfamily. Endocrinology 141: 2254-2256, 2000.

7. Kothapalli, D. and G. R. Grotendorst: CTGF Modulates Cell Cycle Progression in cAMP-Arrested NRK Fibroblasts. J. Cell Physiol. 182: 119-126, 2000.

8. Folger, P. A., D. Zekaria, G. Grotendorst and S. K. Masur: Transforming Growth Factor-b-Stimulated Connective Tissue Growth Factor Expression During Corneal Myofibroblast Differentiation. Invest. Ophthalmol. Vis. Sci. 42: 2534-2541, 2001.

9. Kasaragod, A. B., M. S. Lucia, G. Cabirac, G. R. Grotendorst and K. R. Stenmark: Connective Tissue Growth Factor Expression in Pediatric Myofibroblastic Tumors. Pediatr. Dev. Pathol. 4: 37-45, 2001.

10. Gore-Hyer, E., D. Shegogue, M. Markiewicz, S. Lo, D. Hazen-Martin, E. L. Greene, G. Grotendorst and M. Trojanowska: TGF-b and CTGF have Overlapping and Distinct Fibrogenic Effects on Human Renal Cells. Am. J. Physiol. Renal Physiol. 283: F707-F716, 2002.

11. van Setten, G. B., T. D. Blalock, G. Grotendorst and G. S. Schultz: Detection of Connective Tissue Growth Factor in Human Aqueous Humor. Ophthalmic Res. 5: 306-308, 2002.

12. Blalock, T. D., M. R. Duncan, J. C. Varela, M. H. Goldstein, S. S. Tuli, G. R. Grotendorst and G. S. Schultz: Connective Tissue Growth Factor Expression and Action in Human Corneal Fibroblast Cultures and Rat Corneas After Photorefractive Keratectomy. Invest. Ophthalmol. Vis. Sci. 44: 1879-1887, 2003.

13. Chen, G., G. Grotendorst, T. Eichholtz and N. Khalil: GM-CSF Increases Airway Smooth Muscle Cell Connective Tissue Expression by Inducing TGF-b Receptors. Am. J. Physiol. Lung Cell. Mol. Physiol. 284: L548-L556, 2003.

14. Daniels, J. T., G. S. Schultz, T. D. Blalock, Q. Garrett, G. R. Grotendorst, N. M. Dean and P. T. Khaw: Mediation of Transforming Growth Factor-b₁-Stimulated Matrix Contraction by Fibroblasts: A Role for Connective Tissue Growth Factor in Contractile Scarring. Am. J. Pathol. 163: 2043-2052, 2003.

15. Xu, Y. D., J. Hua, A. Mui, R. O'Connor, G. Grotendorst and N. Khalil: Release of Biologically Active TGF-b1 by Alveolar Epithelial Cells Results in Pulmonary Fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L527-L539, 2003.

16. Esson, D. W., A. Neelakantan, S. A. Iyer, T. D. Blalock, L. Balasubramanian, G. R. Grotendorst, G. S. Schultz and M. B. Sherwood: Expression of Connective Tissue Growth Factor After Glaucoma Filtration Surgery in a Rabbit Model. Invest. Ophthalmol. Vis. Sci. 45: 485-491, 2004.

17. Garrett, Q., P. T. Khaw, T. D. Blalock, G. S. Schultz, G. R. Grotendorst and J. T. Daniels: Involvement of CTGF in TGF-b1-Stimulation of Myofibroblast Differentiation and Collagen Matrix Contraction in the Presence of Mechanical Stress. Invest. Ophthalmol. Vis. Sci. 45: 1109-1116, 2004.

18. Grotendorst, G. R., H. Rahmanie and M. R. Duncan: Combinatorial Signaling Pathways Determine Fibroblast Proliferation and Myofibroblast Differentiation. FASEB J. 18: 469-479, 2004.

19. Grotendorst, G. R. and M. R. Duncan: Individual Domains of Connective Tissue Growth Factor Regulate Fibroblast Proliferation and Myofibroblast Differentiation. FASEB J. 19(7): 729-738, 2005.

20. Kale, S., J. I. Hanai, B. Chan, A. Karihaloo, G. Grotendorst, L. G. Cantley and V. P. Sukhatme: Microarray Analysis of In Vitro Pericyte Differentiation Reveals an Angiogenic Program of Gene Expression. FASEB J. 19(2): 270-271, 2005.