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CAMPEN, MATTHEW J., PHD CONTACT INFORMATION e-mail: mcampen@salud.unm.edu

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EDUCATION
B.S. (Biochemistry & Psychology) 1994, Virginia Polytechnic Institute and State
     University
M.S.P.H. (Environmental Health Science) 1997, The University of North Carolina
     at Chapel Hill
Ph.D. (Environmental Health Science) 2000, The University of North Carolina at
     Chapel Hill

EMPLOYMENT

2009 - Present	Adjunct Scientist, Lovelace Respiratory Research Institute, Albuquerque, NM
2009 - Present	Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
2007 - 2009	Director of Cardiovascular and Respiratory Physiology, Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM
2004 - 2009	Associate Scientist, Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM
2002 - Present	Adjunct Assistant Professor, Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM
2002 - 2004	Associate Research Scientist, Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM
2000 - 2002	Pulmonary Research Fellow, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD
1995 - 2000	Graduate Research Assistant, Pulmonary Toxicology Branch, Health Effects and Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC

HONORS AND AWARDS
Marshall Hahn Scholarship at VPI&SU, 1990
Mary O. Amdur Award for Environmental Inhalation Toxicology, Society of
     Toxicology Meeting, 1999
Individual National Research Service Award, NHLBI, 2001
Graduate Volunteer Faculty Award, College of Pharmacy, University of New
     Mexico, 2006
Research Paper of the Year, 2007, Inhalation and Respiratory Specialty Section,
     Society of Toxicology

PROFESSIONAL AFFILIATIONS
American Physiological Society
American Thoracic Society
Society of Toxicology
American Heart Association
New Mexico NIEHS Center

AREAS OF RESEARCH
Dr. Campen's primary research interests involve how the cardiovascular system may become impaired by insults to the respiratory system. Toxic exposures in the lung may lead to decreased oxygen uptake, alterations in breathing mechanics, stimulation of pulmonary irritant receptors, and generation/release of circulatory mediators, all of which are postulated to affect the cardiovascular system. Working with the NERC studies, electrocardiographic effects of various pollutant atmospheres in healthy and cardiopulmonary-compromised animals are currently being examined.

Additionally, Dr. Campen is interested in the cardiovascular physiology of rodents, especially inbred and transgenic mice. The cardiovascular system of mice has many differences from larger mammals (even rats), including elevated sympathetic baseline tone and heart rate, yet a reduced range of contractile force. Thus, the primary means of altering cardiac output in the mouse is to decrease vascular resistance, rather than alter contractility or rate. Such mechanisms, however, show considerable genetic variation across inbred strains and can be further altered in certain transgenic strains.

REPRESENTATIVE PUBLICATIONS

1. Campen, M. J., M. L. Milazzo, C. Fulhorst, C. J. Obot Akata and F. Koster: Characterization of Shock in a Hamster Model of Hantavirus Infection. Virology 356(1-2): 45-49, 2006.

2. March, T. H., J. A. Wilder, D. C. Esparza, P. Y. Cossey, L. F. Blair, L. K. Herrera, J. D. McDonald, M. J. Campen, J. L. Mauderly and J. Seagrave: Modulators of Cigarette Smoke-Induced Pulmonary Emphysema in A/J Mice. Toxicol. Sci. 92(2): 545-559, 2007.

3. Reed, M. D., M. J. Campen, A. P. Gigliotti, K. S. Harrod, J. D. McDonald, JC. Seagrave, J. L. Mauderly and S. K. Seilkop: Health Effects of Subchronic Exposure to Environmental Levels of Hardwood Smoke. Inhal. Toxicol. 18(8): 523-539, 2006.

4. Zhuang, J., F. Xu, M. Campen, J. Hernandez, S. Shi and R. Wang: Transient Carbon Monoxide Inhibits the Ventilatory Responses to Hypoxia Through Peripheral Mechanisms in the Rat. Life Sci. 78(22): 2654-2661, 2006.

5. Chang, B., M. Crowley, M. Campen and F. Koster: Hantavirus Cardiopulmonary Syndrome. Semin. Respir. Crit. Care Med. 28(2): 193-200, 2007.

6. Lund, A. K., T. L. Knuckles, C. Obot Akata, R. Shohet, J. D. McDonald, A. Gigliotti, JC. Seagrave and M. J. Campen: Gasoline Exhaust Emissions Induce Vascular Remodeling Pathways Involved in Atherosclerosis. Toxicol. Sci. 95(2): 485-494, 2007.

7. McDonald, J. D., M. D. Reed, M. J. Campen, E. G. Barrett, JC. Seagrave and J. L. Mauderly: Health Effects of Inhaled Gasoline Engine Emissions. Inhal. Toxicol. 19(Suppl. 1): 107-116, 2007.

8. Obot Akata, C. J., L. F. Blair, E. B. Barr, S. Storch, G. Vigil and M. J. Campen: Development of a Head-out Plethysmograph System for Non-human Primates in an Animal Biosafety Level 3 Facility. J. Pharmacol. Toxicol. Methods 55(1): 96-102, 2007.

9. Rowan, W. H., M. J. Campen, L. B. Wichers and W. P. Watkinson: Heart Rate Variability in Rodents: Uses and Caveats in Toxicological Studies. Cardiovasc. Toxicol. 7(1): 28-51, 2007.

10. Aragon, A. C., P. G. Kopf, M. J. Campen, J. K. Huwe and M. K. Walker: In Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure: Effects on Fetal and Adult Cardiac Gene Expression and Adult Cardiac and Renal Morphology. Toxicol. Sci. 101(2): 321-330, 2008.

11. Knuckles, T. L., A. K. Lund, S. N. Lucas and M. J. Campen: Diesel Exhaust Exposure Enhances Venoconstriction via Uncoupling of eNOS. Toxicol. Appl. Pharmacol. 230: 346-351, 2008.

12. Mishra, N. C., J. Rir-Sima-ah, R. J. Langley, S. P. Singh, J. C. Peña-Philippides, T. Koga, S. Razani-Boroujerdi, J. Hutt, M. Campen, K. C. Kim, Y. Tesfaigzi and M. L. Sopori: Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens. J. Immunol. 180(11): 7655-7663, 2008.

13. Reed, M. D., E. G. Barrett, M. J. Campen, K. K. Divine, A. P. Gigliotti, J. D. McDonald, JC. Seagrave, S. K. Seilkop, J. A. Swenberg and J. L. Mauderly: Health Effects of Subchronic Inhalation Exposure to Gasoline Engine Emissions. Inhal. Toxicol. 20(13): 1125-1143, 2008.

14. Seagrave, JC., M. J. Campen, J. D. McDonald, J. L. Mauderly and A. C. Rohr: Oxidative Stress, Inflammation, and Pulmonary Function Assessment in Rats Exposed to Laboratory-Generated Pollutant Mixtures. J. Toxicol. Environ. Health A 71(20): 1352-1362, 2008.

15. Zhuang, J., F. Xu, M. J. Campen, C. Zhang, J. C. Pena-Philippides and M. L. Sopori: Inhalation of the Nerve Gas Sarin Impairs Ventilatory Responses to Hypercapnia and Hypoxia in Rats. Toxicol. Appl. Pharmacol. 232(3): 440-447, 2008.

16. Campen, M. J.: Nitric Oxide Synthase: “Enzyme Zero” in Air Pollution-Induced Vascular Toxicity. Toxicol. Sci. 110(1): 1-3, 2009.

17. Cherng, T. W., M. J. Campen, T. L. Knuckles, L. V. Gonzales Bosc and N. L. Kanagy: Impairment of Coronary Endothelial Cell ETB Receptor Function Following Short-Term Inhalation Exposure to Whole Diesel Emissions. Am. J. Physiol. Regul. Integr. Comp. Physiol. Jun 17 [Epub ahead of print], 2009.

18. Lund, A. K., J. Lucero, S. Lucas, M. C. Madden, J. D. McDonald, JC. Seagrave, T. L. Knuckles and M. J. Campen: Vehicular Emissions Iinduce Vascular MMP-9 Expression and Activity Associated with Endothelin-1-Mediated Pathways. Arterioscler. Thromb. Vasc. Biol. 29(4): 511-517, 2009.