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BENSON, JANET M., PHD, DABT CONTACT INFORMATION Fax: (505) 348-4980 e-mail: jbenson@LRRI.org Extended CV

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EDUCATION
B.S. (Chemistry) 1972, University of California-Berkeley
Ph.D. (Comparative Pharmacology & Toxicology) 1978, University of California-Davis

PROFESSIONAL CERTIFICATION (by examination)
Diplomate, American Board of Toxicology, 1981

EMPLOYMENT

2001 - Present	Clinical Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1997 - Present	Senior Scientist; Program Manager, Applied Toxicology and Gene Therapy Pharmacology/Toxicity Program (formerly Applied Toxicology Program), Lovelace Respiratory Research Institute, Albuquerque, NM
1989 - 1997	Scientist, Inhalation Toxicology Research Institute, Albuquerque, NM
1987 - 2000	Clinical Associate Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM
1977 - 1989	Associate Scientist/Toxicologist, Inhalation Toxicology Research Institute, Albuquerque, NM

PROFESSIONAL AFFILIATIONS
American Chemical Society
Society of Toxicology
American Association of Pharmaceutical Scientists
International Society for the Study of Harmful Algae
American Conference of Government Industrial Hygientists

AREAS OF RESEARCH
Dr. Benson's areas of research include toxicological evaluations of single compounds and complex mixtures of occupational and environmental concern. A major research focus involves evaluation of potential adverse health effects resulting from inhalation or ingestion of marine and fresh water algal toxins. Her laboratory is also currently conducting bioassays evaluating the carcinogenicity of gasoline fuel vapors. Dr. Benson has had extensive experience in the conduct of inhalation studies, including toxicokinetic and mechanistic evaluations of a variety of materials such as metals, solvents, and polymers.

REPRESENTATIVE PUBLICATIONS

1. Benson, J. M., A. M. Holmes, E. B. Barr, K. J. Nikula and T. H. March: Particle Clearance and Histopathology in Lungs of C3H/HeJ Mice Administered Beryllium/Copper Alloy by Intratracheal Instillation. Inhal. Toxicol. 12: 733-749, 2000.

2. Thrall, K. D., M. E. Vucelick, R. A. Gies, R. C. Zangar, K. K. Weitz, T. S. Poet, D. L. Springer, D. M. Grant and J. M. Benson: Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling. J. Toxicol. Environ. Health Part A, 60: 531-548, 2000.

3. Zangar, R. C., J. M. Benson, V. L. Burnett and D. L. Springer: Cytochrome P450 2E1 is the Primary Enzyme Responsible for Low-Dose Carbon Tetrachloride Metabolism in Human Liver Microsomes. Chem. Biol. Interact. 125: 233-243, 2000.

4. Benson, J. M., B. M. Tibbetts, K. D. Thrall and D. L. Springer: Uptake, Tissue Distribution, and Fate of Inhaled Carbon Tetrachloride: Comparison of Rat, Mouse, and Hamster. Inhal. Toxicol. 13(3): 207-217, 2001.

5. Backer, L. C., L. E. Fleming, A. Rowan, Y. S. Cheng, J. Benson, R. H. Pierce, J. Zaias, J. Bean, G. D. Bossari and D. Johnson: Recreational Exposure to Aerosolized Brevetoxins During Florida Red Tide Events. Harmful Algae 2: 19-28, 2003.

6. Benson, J. M., B. M. Tibbetts and E. B. Barr: The Uptake, Distribution, Metabolism, and Excretion of Methyl Tertiary-Butyl Ether Inhaled Alone and in Combination with Gasoline Vapor. J. Toxicol. Environ. Health A 66: 1029-1052, 2003.

7. Campen, M. J., J. D. McDonald, A. P. Gigliotti, S. K. Seilkop, M. D. Reed and J. M. Benson: Cardiovascular Effects of Inhaled Diesel Exhaust in Spontaneously Hypertensive Rats. Cardiovasc. Toxicol. 3(4): 353-361, 2003.

8. Muggenburg, B. A., J. M. Benson, E. B. Barr, J. Kubatko and L. P. Tilley: Short-Term Inhalation of Particulate Transition Metals Has Little Effect on the Electrocardiograms of Dogs Having Preexisting Cardiac Abnormalities. Inhal. Toxicol. 15: 357-371, 2003.

9. Benson, J., F. Hahn, T. March, J. McDonald, M. Sopori, J. Seagrave, A. Gomez, A. Bourdelais, J. Naar, J. Zaias, G. Bossart and D. Baden: Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for 5 Days. J. Toxicol. Environ. Health A 67(18): 1143-1156, 2004.

10. Kirkpatrick, B., L. E. Fleming, D. Squicciarini, L. C. Backer, R. Clark, W. Abraham, J. Benson, Y. S. Cheng, D. Johnson, R. Pierce, J. Zaias, G. Bossart and D. G. Baden: Literature Review of Red Tide: Implication for Human Health Effects. Harmful Algae 3(2): 99-115, 2004.

11. Langley, R. J., R. Kalra, N. C. Mishra, F. F. Hahn, S. Razani-Boroujerdi, S. P. Singh, J. M. Benson, J. C. Pena-Philippides, E. B. Barr and M. L. Sopori: A Biphasic Response to Silica. I. Immunostimulation is Restricted to the Early Stage of Silicosis in Lewis Rats. Am. J. Respir. Cell Mol. Biol. 30: 823-829, 2004.

12. Benson, J. M., F. F. Hahn, T. H. March, J. D. McDonald, A. P. Gomez, M. L. Sopori, A. J. Bourdelais, J. Naar, J. Zaias, G. D. Bossart and D. G. Baden: Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for Twenty-two Days. Environ. Health Perspect. 113: 626-631, 2005.

13. Benson, J. M., J. A. Hutt, K. Rein, S. E. Boggs, E. B. Barr and L. E. Fleming: The Toxicity of Microcystin LR in Mice Following 7 Days of Inhalation Exposure. Toxicon 45(6): 691-698, 2005.

14. Benson, J. M., B. B. Stagner, G. K. Martin, M. Friedman, S. E. Durr, A. Gomez, J. McDonald, L. E. Fleming, L. C. Backer, D. G. Baden, A. Bourdelais, J. Naar and B. L. Lonsbury-Martin: Cochlear Function in Mice Following Inhalation of Brevetoxin 3. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 191(7): 619-626, 2005.

15. Benson, J. M., A. P. Gomez, G. L. Statom, B. M. Tibbetts, L. E. Fleming, L. E. Backer, A. Reich and D. G. Baden: Placental Transport of Brevetoxin-3 in CD-1 Mice. Toxicon 48(8): 1018-1026, 2006.

16. Tibbetts, B. M., D. G. Baden and J. M. Benson: Uptake, Tissue Distribution, and Excretion of Brevetoxin-3 Administered to Mice by Intratracheal Instillation. J. Toxicol. Environ. Health A 69(14): 1325-1335, 2006.

17. Yan, X., J. M. Benson, A. P. Gomez, D. G. Baden and T. F. Murray: Brevetoxin-Induced Neural Insult in the Retrosplenial Cortex of Mouse Brain. Inhal. Toxicol. 18(14): 1109-1116, 2006.

18. Zhou, Y., J. M. Benson, C. Irvin, H. Irshad and Y. S. Cheng: Particle Size Distribution and Inhalation Dose of Shower Water Under Selected Operating Conditions. Inhal. Toxicol. 19(4): 333-342, 2007.

19. Bogen, K. T., J. M. Benson, G. S. Yost, J. B. Morris, A. R. Dahl, H. J. Clewell, 3rd, K. Krishnan and C. J. Omiecinski: Naphthalene Metabolism in Relation to Target Tissue Anatomy, Physiology, Cytotoxicity and Tumorigenic Mechanism of Action. Regul. Toxicol. Pharmacol. 51(2 Suppl. 1): S27-S36, 2008.

20. North, D. W., K. M. Abdo, J. M. Benson, A. R. Dahl, J. B. Morris, R. Renne and H. Witschi: A Review of Whole Animal Bioassays of the Carcinogenic Potential of Naphthalene. Regul. Toxicol. Pharmacol. 51(2 Suppl. 1): S6-S14, 2008.

21. Fleming, L. E., J. A. Bean, B. Kirkpatrick, Y. S. Cheng, R. Pierce, J. Naar, K. Nierenberg, L. C. Backer, A. Wanner, A. Reich, Y. Zhou, S. Watkins, M. Henry, J. Zaias, W. M. Abraham, J. Benson, A. Cassedy, J. Hollenbeck, G. Kirkpatrick, T. Clarke and D. G. Baden: Exposure and Effects Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma. Environ. Health Perspect. 117(7): 1095-1100, 2009.