Inhalation Toxicology

The Lovelace Respiratory Research Institute conducts a full range of inhalation bioassays in its well-known inhalation toxicology laboratory and is widely known for its leadership in the field. We integrate leading-edge expertise in generation and characterization of exposure atmospheres, exposure technology, dosimetry, and evaluation of health outcomes, as needed to meet study goals.

The facility has capabilities and capacity to conduct single or repeated, nose-only, oral, or whole-body inhalation exposures of all laboratory species. Exposures range from individual animals for preliminary investigations to large-scale carcinogenicity bioassays.

The Institute has broad experience with exposures of animals to gases, vapors, and particles, exposures using limited quantities of materials, exposures to hazardous and radioactive materials, and exposures to complex mixtures. Our scientists work with sponsors during all phases of studies from experimental design to interpretation of findings.

Key Capabilities:

• Compliance with Good Laboratory Practice regulations and other customer requirements
• Collaboration with sponsor on experimental design and interpretation of results
• Novel exposure techniques for developmental work and pilot studies, including measurement and control of respiration in all species, simulation of human oral dosing using dogs and primates, and exposure by intratracheal instillation or via bronchoscopy
• Wide range of dosimetric, toxicokinetic, clinical, physiological, and genetic assays
• Exposures to gases, vapors, fibrous and nonfibrous particles, and to engine exhaust and other actual or synthesized complex mixtures
• Generation and exposure to radiolabeled and radioactive materials
• Full histopathology, immunohistochemistry, and morphometric capability

In Addition

• AAALAC accredited animal facilities
• Approved waste streams for hazardous materials
• Confidentiality, proprietary, and intellectual property agreements
• Collaboration with customer's in-house investigations